{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:54:07Z","timestamp":1790952847363,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin A deficiency leads to increased susceptibility to a spectrum of infectious diseases. The studies presented dissect the intrinsic role of each of the retinoic acid receptor (RAR) isoforms in the clonal expansion, differentiation, and survival of pathogen-specific CD8 T cells in vivo. The data show that RAR\u03b1 is required for the expression of gut-homing receptors on CD8+ T cells and survival of CD8+ T cells in vitro. Furthermore, RAR\u03b1 is essential for survival of CD8+ T cells in vivo following Listeria monocytogenes infection. In contrast, RAR\u03b2 deletion leads to modest deficiency in Ag-specific CD8+ T cell expansion during infection. The defective survival of RAR\u03b1-deficient CD8+ T cells leads to a deficiency in control of L. monocytogenes expansion in the spleen. To our knowledge, these are the first comparative studies of the role of RAR isoforms in CD8+ T cell immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1301949","type":"journal-article","created":{"date-parts":[[2014,3,8]],"date-time":"2014-03-08T05:42:26Z","timestamp":1394257346000},"page":"3336-3344","source":"Crossref","is-referenced-by-count":23,"title":["Dissecting the Role of Retinoic Acid Receptor Isoforms in the CD8 Response to Infection"],"prefix":"10.1093","volume":"192","author":[{"given":"Yanxia","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center , Lebanon, NH 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center , Lebanon, NH 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysothemis","family":"Brown","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Transplantation, Guy\u2019s Hospital, King\u2019s College London, King\u2019s Health Partners , London SE1 9RT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center , Lebanon, NH 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Usherwood","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center , Lebanon, NH 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolph J","family":"Noelle","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center , Lebanon, NH 03756"},{"name":"Medical Research Council Centre for Transplantation, Guy\u2019s Hospital, King\u2019s College London, King\u2019s Health Partners , London SE1 9RT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"2025032404212165400_r1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/BF03405454","article-title":"Neonatal vitamin A deficiency and its impact on acute respiratory infections among preschool Inuit children","volume":"99","author":"Cameron","year":"2008","journal-title":"Can. 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