{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:44:47Z","timestamp":1791305087991,"version":"4.3.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We document human T lymphotropic virus type 1 (HTLV-1) bZIP factor (HBZ)-specific CD4 T cell responses in an adult T cell leukemia\/lymphoma (ATL) patient after allogeneic hematopoietic stem cell transplantation (HCT) and identified a novel HLA-DRB1*15:01\u2013restricted HBZ-derived naturally presented minimum epitope sequence, RRRAEKKAADVA (HBZ114\u2013125). This peptide was also presented on HLA-DRB1*15:02, recognized by CD4 T cells. Notably, HBZ-specific CD4 T cell responses were only observed in ATL patients after allogeneic HCT (4 of 9 patients) and not in nontransplanted ATL patients (0 of 10 patients) or in asymptomatic HTLV-1 carriers (0 of 10 carriers). In addition, in one acute-type patient, HBZ-specific CD4 T cell responses were absent in complete remission before HCT, but they became detectable after allogeneic HCT. We surmise that HTLV-1 transmission from mothers to infants through breast milk in early life induces tolerance to HBZ and results in insufficient HBZ-specific T cell responses in HTLV-1 asymptomatic carriers or ATL patients. In contrast, after allogeneic HCT, the reconstituted immune system from donor-derived cells can recognize virus protein HBZ as foreign, and HBZ-specific immune responses are provoked that contribute to the graft-versus-HTLV-1 effect.<\/jats:p>","DOI":"10.4049\/jimmunol.1301952","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T06:33:42Z","timestamp":1387607622000},"page":"940-947","source":"Crossref","is-referenced-by-count":17,"title":["HTLV-1 bZIP Factor\u2013Specific CD4 T Cell Responses in Adult T Cell Leukemia\/Lymphoma Patients after Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1093","volume":"192","author":[{"given":"Tomoko","family":"Narita","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences , Nagoya 467-8601,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences , Nagoya 467-8601,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences , Nagoya 467-8601,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences , Nagoya 467-8601,","place":["Japan"]},{"name":"Department of Tumor Immunology, Aichi Medical University School of Medicine , Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences , Nagoya 467-8601,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences , Nagoya 467-8601,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomiko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences , Nagoya 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