{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:43:42Z","timestamp":1780497822296,"version":"3.54.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A Salmonella therapeutic expressing enterotoxigenic Escherichia coli colonization factor Ag I (CFA\/I) fimbriae protects against collagen-induced arthritis (CIA) by eliciting two regulatory T cell (Treg) subsets: TGF-\u03b2\u2013producing Foxp3\u2212CD39+CD4+ T cells and IL-10\u2013producing Foxp3+CD39+CD4+ T cells. However, it is unclear whether CFA\/I fimbriae alone are protective and whether other regulatory cytokines are involved, especially in the context for the EBI3-sharing cytokines, Treg-derived IL-35 and APC-derived IL-27, both capable of suppressing Th17 cells and regulating autoimmune diseases. Subsequent evaluation revealed that a single oral dose of purified, soluble CFA\/I fimbriae protected against CIA as effectively as did Salmonella-CFA\/I and found that Foxp3+CD39+CD4+ T cells were the source of secreted IL-35, whereas IL-27 production by CD11c+ cells was inhibited. Inquiring into their relevance, CFA\/I fimbriae\u2013treated IL-27R\u2013deficient (WSX-1\u2212\/\u2212) mice were equally protected against CIA as were wild-type mice, suggesting a limited role for IL-27. In contrast, CFA\/I fimbriae\u2013mediated protection was abated in EBI3\u2212\/\u2212 mice, accompanied by the loss of TGF-\u03b2\u2013 and IL-10\u2013producing Tregs. Adoptive transfer of C57BL\/6 CD39+CD4+ T cells to EBI3\u2212\/\u2212 mice with concurrent CFA\/I plus IL-35 treatment effectively stimulated Tregs suppressing proinflammatory collagen II\u2013specific Th cells. In contrast, recipients cotransferred with C57BL\/6 and EBI3\u2212\/\u2212 CD39+CD4+ T cells and treated with CFA\/I plus IL-35 were not protected, implicating the importance of endogenous IL-35 for conferring CFA\/I-mediated protection. Thus, CFA\/I fimbriae stimulate IL-35 required for the coinduction of TGF-\u03b2 and IL-10.<\/jats:p>","DOI":"10.4049\/jimmunol.1302018","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T03:26:31Z","timestamp":1386818791000},"page":"804-816","source":"Crossref","is-referenced-by-count":25,"title":["Oral <i>Escherichia coli<\/i> Colonization Factor Antigen I Fimbriae Ameliorate Arthritis via IL-35, Not IL-27"],"prefix":"10.1093","volume":"192","author":[{"given":"Irina","family":"Kochetkova","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, MT 59717"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, MT 59717"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle","family":"Callis","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, MT 59717"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Holderness","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Montana State University , Bozeman, MT 59717"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Maddaloni","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathology, University of Florida , Gainesville, FL 32611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathology, University of Florida , Gainesville, FL 32611"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"2025032404074694000_r1","doi-asserted-by":"crossref","first-page":"v3","DOI":"10.1093\/rheumatology\/kes113","article-title":"Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis","volume":"51","author":"Choy","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"2025032404074694000_r2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0047-6374(01)00371-2","article-title":"The molecular pathogenesis of collagen-induced arthritis in mice\u2014a model for rheumatoid arthritis","volume":"1","author":"Holmdahl","year":"2002","journal-title":"Ageing Res. Rev."},{"key":"2025032404074694000_r3","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/ard.47.9.768","article-title":"Tumour necrosis factor in synovial exudates","volume":"47","author":"Di Giovine","year":"1988","journal-title":"Ann. Rheum. Dis."},{"key":"2025032404074694000_r4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","article-title":"Role of cytokines in rheumatoid arthritis","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"2025032404074694000_r5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1600-065X.1995.tb00070.x","article-title":"Monoclonal anti-TNF \u03b1 antibody as a probe of pathogenesis and therapy of rheumatoid disease","volume":"144","author":"Maini","year":"1995","journal-title":"Immunol. Rev."},{"key":"2025032404074694000_r6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"2025032404074694000_r7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1056\/NEJM199707173370301","article-title":"Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein","volume":"337","author":"Moreland","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"2025032404074694000_r8","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1056\/NEJM200011303432202","article-title":"Infliximab and methotrexate in the treatment of rheumatoid arthritis","volume":"343","author":"Lipsky","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"2025032404074694000_r9","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.autrev.2011.04.010","article-title":"Anti-TNF therapy: safety aspects of taking the risk","volume":"10","author":"Rosenblum","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"2025032404074694000_r10","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3899\/jrheum.100623","article-title":"Challenges in diagnosing latent tuberculosis infection in patients treated with tumor necrosis factor antagonists","volume":"38","author":"Keystone","year":"2011","journal-title":"J. Rheumatol."},{"key":"2025032404074694000_r11","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1073\/pnas.88.7.2918","article-title":"Protective effect of transforming growth factor \u03b21 on experimental autoimmune diseases in mice","volume":"88","author":"Kuruvilla","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032404074694000_r12","doi-asserted-by":"crossref","first-page":"R212","DOI":"10.1186\/ar3545","article-title":"IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis","volume":"13","author":"Tao","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"2025032404074694000_r13","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1002\/art.34513","article-title":"Antigen-specific transforming growth factor \u03b2-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17\/Treg cell balance from Th17 predominance to Treg cell predominance","volume":"64","author":"Kong","year":"2012","journal-title":"Arthritis Rheum."},{"key":"2025032404074694000_r14","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1186\/ar601","article-title":"Collagen-induced arthritis is exacerbated in IL-10-deficient mice","volume":"5","author":"Finnegan","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"2025032404074694000_r15","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.4049\/jimmunol.178.3.1791","article-title":"Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis","volume":"178","author":"Ochoa-Rep\u00e1raz","year":"2007","journal-title":"J. Immunol."},{"key":"2025032404074694000_r16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-5728(00)00384-2","article-title":"Modulation of the IL-10\/IL-12 cytokine circuit by interferon-beta inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis","volume":"111","author":"Tuohy","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"2025032404074694000_r17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/intimm\/dxh029","article-title":"IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells","volume":"16","author":"Zhang","year":"2004","journal-title":"Int. Immunol."},{"key":"2025032404074694000_r18","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/eji.200737810","article-title":"IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells","volume":"37","author":"Niedbala","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2025032404074694000_r19","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.immuni.2012.03.024","article-title":"Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1","volume":"36","author":"Hirahara","year":"2012","journal-title":"Immunity"},{"key":"2025032404074694000_r20","doi-asserted-by":"crossref","first-page":"12041","DOI":"10.1073\/pnas.94.22.12041","article-title":"Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin","volume":"94","author":"Devergne","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032404074694000_r21","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nature06306","article-title":"The inhibitory cytokine IL-35 contributes to regulatory T-cell function","volume":"450","author":"Collison","year":"2007","journal-title":"Nature"},{"key":"2025032404074694000_r22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/ni.2227","article-title":"The composition and signaling of the IL-35 receptor are unconventional","volume":"13","author":"Collison","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025032404074694000_r23","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.4049\/jimmunol.0902739","article-title":"IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10","volume":"184","author":"Kochetkova","year":"2010","journal-title":"J. Immunol."},{"key":"2025032404074694000_r24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jaci.2011.08.009","article-title":"IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease","volume":"129","author":"Whitehead","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032404074694000_r25","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1074-7613(02)00324-2","article-title":"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells","volume":"16","author":"Pflanz","year":"2002","journal-title":"Immunity"},{"key":"2025032404074694000_r26","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.4049\/jimmunol.170.10.4886","article-title":"Cutting edge: role of IL-27\/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment","volume":"170","author":"Takeda","year":"2003","journal-title":"J. Immunol."},{"key":"2025032404074694000_r27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1074-7613(03)00298-X","article-title":"WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production","volume":"19","author":"Hamano","year":"2003","journal-title":"Immunity"},{"key":"2025032404074694000_r28","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.4049\/jimmunol.173.2.1171","article-title":"Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27","volume":"173","author":"Goldberg","year":"2004","journal-title":"J. Immunol."},{"key":"2025032404074694000_r29","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.4049\/jimmunol.173.10.6465","article-title":"Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27","volume":"173","author":"Goldberg","year":"2004","journal-title":"J. Immunol."},{"key":"2025032404074694000_r30","doi-asserted-by":"crossref","first-page":"922","DOI":"10.4049\/jimmunol.180.2.922","article-title":"IL-27 induces a Th1 immune response and susceptibility to experimental arthritis","volume":"180","author":"Cao","year":"2008","journal-title":"J. Immunol."},{"key":"2025032404074694000_r31","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/ni1540","article-title":"Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells","volume":"8","author":"Fitzgerald","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025032404074694000_r32","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.4049\/jimmunol.0801162","article-title":"IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells","volume":"182","author":"Diveu","year":"2009","journal-title":"J. Immunol."},{"key":"2025032404074694000_r33","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.4049\/jimmunol.1100106","article-title":"Increased Th17 and regulatory T cell responses in EBV-induced gene 3-deficient mice lead to marginally enhanced development of autoimmune encephalomyelitis","volume":"188","author":"Liu","year":"2012","journal-title":"J. Immunol."},{"key":"2025032404074694000_r34","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni1375","article-title":"Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells","volume":"7","author":"Batten","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032404074694000_r35","first-page":"15","article-title":"Vaccines for enterotoxigenic Escherichia coli: current status","volume":"21","author":"Boedeker","year":"2005","journal-title":"Curr. Opin. Gastroenterol."},{"key":"2025032404074694000_r36","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1128\/iai.63.12.4933-4938.1995","article-title":"Immune responses to novel Escherichia coli and Salmonella typhimurium vectors that express colonization factor antigen I (CFA\/I) of enterotoxigenic E. coli in the absence of the CFA\/I positive regulator cfaR","volume":"63","author":"Wu","year":"1995","journal-title":"Infect. Immun."},{"key":"2025032404074694000_r37","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1128\/IAI.67.12.6249-6256.1999","article-title":"Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response","volume":"67","author":"Pascual","year":"1999","journal-title":"Infect. Immun."},{"key":"2025032404074694000_r38","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1128\/IAI.70.8.4273-4281.2002","article-title":"Fimbriated Salmonella enterica serovar typhimurium abates initial inflammatory responses by macrophages","volume":"70","author":"Pascual","year":"2002","journal-title":"Infect. Immun."},{"key":"2025032404074694000_r39","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.4049\/jimmunol.175.10.6733","article-title":"A live diarrheal vaccine imprints a Th2 cell bias and acts as an anti-inflammatory vaccine","volume":"175","author":"Jun","year":"2005","journal-title":"J. Immunol."},{"key":"2025032404074694000_r40","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.4049\/jimmunol.181.4.2741","article-title":"Vaccination without autoantigen protects against collagen II-induced arthritis via immune deviation and regulatory T cells","volume":"181","author":"Kochetkova","year":"2008","journal-title":"J. Immunol."},{"key":"2025032404074694000_r41","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.4049\/jimmunol.1100530","article-title":"Segregated regulatory CD39+CD4+ T cell function: TGF-\u03b2-producing Foxp3- and IL-10-producing Foxp3+ cells are interdependent for protection against collagen-induced arthritis","volume":"187","author":"Kochetkova","year":"2011","journal-title":"J. Immunol."},{"key":"2025032404074694000_r42","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.autrev.2009.12.013","article-title":"Neutrophils in rheumatoid arthritis: More than simple final effectors","volume":"9","author":"Casc\u00e3o","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"2025032404074694000_r43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s007760050147","article-title":"Mechanisms of joint destruction in rheumatoid arthritis","volume":"5","author":"Jasin","year":"2000","journal-title":"J. Orthop. Sci."},{"key":"2025032404074694000_r44","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.berh.2010.01.007","article-title":"Treating to re-establish tolerance in inflammatory arthritis - lessons from other diseases","volume":"24","author":"Cooles","year":"2010","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"2025032404074694000_r45","first-page":"295","article-title":"The mouse model of collagen-induced arthritis","volume":"102","author":"Brand","year":"2004","journal-title":"Methods Mol. Med."},{"key":"2025032404074694000_r46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10067-012-2041-1","article-title":"Advances in research on animal models of rheumatoid arthritis","volume":"32","author":"Hu","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"2025032404074694000_r47","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1002\/art.30556","article-title":"Pharmacologic P2X purinergic receptor antagonism in the treatment of collagen-induced arthritis","volume":"63","author":"Ardissone","year":"2011","journal-title":"Arthritis Rheum."},{"key":"2025032404074694000_r48","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1182\/blood-2006-12-064527","article-title":"Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression","volume":"110","author":"Borsellino","year":"2007","journal-title":"Blood"},{"key":"2025032404074694000_r49","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"Deaglio","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025032404074694000_r50","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nm0402-358","article-title":"CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness","volume":"8","author":"Mizumoto","year":"2002","journal-title":"Nat. Med."},{"key":"2025032404074694000_r51","doi-asserted-by":"crossref","first-page":"14791","DOI":"10.1074\/jbc.M110.116905","article-title":"cAMP\/CREB-mediated transcriptional regulation of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) expression","volume":"285","author":"Liao","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2025032404074694000_r52","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ni.1952","article-title":"IL-35-mediated induction of a potent regulatory T cell population","volume":"11","author":"Collison","year":"2010","journal-title":"Nat. Immunol."},{"key":"2025032404074694000_r53","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.it.2011.11.003","article-title":"New directions in the basic and translational biology of interleukin-27","volume":"33","author":"Wojno","year":"2012","journal-title":"Trends Immunol."},{"key":"2025032404074694000_r54","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1136\/ard.2007.083360","article-title":"Interleukin 27 attenuates collagen-induced arthritis","volume":"67","author":"Niedbala","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"2025032404074694000_r55","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1002\/art.30324","article-title":"Local expression of interleukin-27 ameliorates collagen-induced arthritis","volume":"63","author":"Pickens","year":"2011","journal-title":"Arthritis Rheum."},{"key":"2025032404074694000_r56","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cyto.2011.04.020","article-title":"IL-27-producing CD14+ cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration","volume":"55","author":"Tanida","year":"2011","journal-title":"Cytokine"},{"key":"2025032404074694000_r57","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.4049\/jimmunol.1201017","article-title":"A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes","volume":"190","author":"Kim","year":"2013","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/192\/2\/804\/62511268\/1302018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/192\/2\/804\/62511268\/1302018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T04:43:47Z","timestamp":1742791427000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/192\/2\/804\/7993390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,1,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1302018","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,1]]},"published":{"date-parts":[[2014,1]]}}}