{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:59:58Z","timestamp":1775087998156,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitiligo is a CD8 T cell\u2013mediated autoimmune disease that has been shown to promote the longevity of memory T cell responses to melanoma. However, mechanisms whereby melanocyte\/melanoma Ag-specific T cell responses are perpetuated in the context of vitiligo are not well understood. These studies investigate the possible phenomenon of naive T cell priming in hosts with melanoma-initiated, self-perpetuating, autoimmune vitiligo. Using naive pmel (gp10025\u201333\u2013specific) transgenic CD8 T cells, we demonstrate that autoimmune melanocyte destruction induces naive T cell proliferation in skin-draining lymph nodes, in an Ag-dependent fashion. These pmel T cells upregulate expression of CD44, P-selectin ligand, and granzyme B. However, they do not downregulate CD62L, nor do they acquire the ability to produce IFN-\u03b3, indicating a lack of functional priming. Accordingly, adult thymectomized mice exhibit no reduction in the severity or kinetics of depigmentation or long-lived protection against melanoma, indicating that the continual priming of naive T cells is not required for vitiligo or its associated antitumor immunity. Despite this, depletion of CD4 T cells during the course of vitiligo rescues the priming of naive pmel T cells that are capable of producing IFN-\u03b3 and persisting as memory, suggesting an ongoing and dominant mechanism of suppression by regulatory T cells. This work reveals the complex regulation of self-reactive CD8 T cells in vitiligo and demonstrates the overall poorly immunogenic nature of this autoimmune disease setting.<\/jats:p>","DOI":"10.4049\/jimmunol.1302139","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T05:39:45Z","timestamp":1389245985000},"page":"1433-1439","source":"Crossref","is-referenced-by-count":20,"title":["Autoimmune Vitiligo Does Not Require the Ongoing Priming of Naive CD8 T Cells for Disease Progression or Associated Protection against Melanoma"],"prefix":"10.1093","volume":"192","author":[{"given":"Katelyn T","family":"Byrne","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, NH 03755; and , Lebanon, NH 03756"},{"name":"Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center , Hanover, NH 03755; and , Lebanon, NH 03756"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peisheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, NH 03755; and , Lebanon, NH 03756"},{"name":"Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center , Hanover, NH 03755; and , Lebanon, NH 03756"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon M","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, NH 03755; and , Lebanon, NH 03756"},{"name":"Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center , Hanover, NH 03755; and , Lebanon, NH 03756"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Jo","family":"Turk","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, NH 03755; and , Lebanon, NH 03756"},{"name":"Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center , Hanover, NH 03755; and , Lebanon, NH 03756"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,15]]},"reference":[{"key":"2025032404130265100_r1","first-page":"254","article-title":"Case of leukoderma in X-ray portion of patient with melanosarcoma","volume":"2","author":"Matsuzawa","year":"1953","journal-title":"Shinshu Med. 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