{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:04:47Z","timestamp":1791288287138,"version":"4.3.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>DNAX accessory molecule 1 (DNAM-1) is expressed on all CD8+ T cells and promotes their activation and effector function. DNAM-1 interacts with LFA-1, a critical molecule for immunological synapse formation between T cells and APCs, and for cytotoxic killing of target cells. Mice that lack DNAM-1 display abnormal T cell responses and antitumor activity; however, the mechanism involved is unclear. In this article, we show that DNAM-1 deficiency results in reduced proliferation of CD8+ T cells after Ag presentation and impaired cytotoxic activity. We also demonstrate that DNAM-1\u2013deficient T cells show reduced conjugations with tumor cells and decreased recruitment of both LFA-1 and lipid rafts to the immunological synapse, which correlates with reduced tumor cell killing in vitro. This synapse defect may explain why DNAM-1\u2013deficient mice cannot clear tumors in vivo, and highlights the importance of DNAM-1 and the immunological synapse in T cell\u2013mediated antitumor immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1302197","type":"journal-article","created":{"date-parts":[[2013,12,14]],"date-time":"2013-12-14T03:19:59Z","timestamp":1386991199000},"page":"553-557","source":"Crossref","is-referenced-by-count":48,"title":["Cutting Edge: DNAX Accessory Molecule 1\u2013Deficient CD8+ T Cells Display Immunological Synapse Defects That Impair Antitumor Immunity"],"prefix":"10.1093","volume":"192","author":[{"given":"Kelly M","family":"Ramsbottom","sequence":"first","affiliation":[{"name":"Cancer Immunology, Peter MacCallum Cancer Centre , East Melbourne 3002, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin D","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Peter MacCallum Cancer Centre , East Melbourne 3002, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raz","family":"Shimoni","sequence":"additional","affiliation":[{"name":"Centre for Micro-Photonics, Swinburne University , Hawthorn 3122, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairi","family":"McGrath","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Peter MacCallum Cancer Centre , East Melbourne 3002, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Chan","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Peter MacCallum Cancer Centre , East Melbourne 3002, Victoria,","place":["Australia"]},{"name":"Department of Immunology, Monash University , Clayton 3168, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M","family":"Russell","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Peter MacCallum Cancer Centre , East Melbourne 3002, Victoria,","place":["Australia"]},{"name":"Centre for Micro-Photonics, Swinburne University , Hawthorn 3122, Victoria,","place":["Australia"]},{"name":"Sir Peter MacCallum Department of Oncology, The University of Melbourne , Parkville 3052, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Smyth","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Peter MacCallum Cancer Centre , East Melbourne 3002, Victoria,","place":["Australia"]},{"name":"Department of Immunology, Monash University , Clayton 3168, Victoria,","place":["Australia"]},{"name":"Immunology in Cancer and Infection Laboratory, Queensland Institute of Medical Research , Herston 4006, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Oliaro","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Peter MacCallum Cancer Centre , East Melbourne 3002, Victoria,","place":["Australia"]},{"name":"Sir Peter MacCallum Department of Oncology, The University of Melbourne , Parkville 3052, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"2025032404083947400_r1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.immuni.2011.07.010","article-title":"CD8(+) T cells: foot soldiers of the immune system","volume":"35","author":"Zhang","year":"2011","journal-title":"Immunity"},{"key":"2025032404083947400_r2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-immunol-031210-101324","article-title":"Natural innate and adaptive immunity to cancer","volume":"29","author":"Vesely","year":"2011","journal-title":"Annu. 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