{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:33:07Z","timestamp":1791387187809,"version":"4.3.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During reinfection, high-affinity IgG Abs form complexes with both soluble Ag and Ag displayed on the surface of infected cells. These interactions regulate cellular activation of both innate cells and B cells, which express specific combinations of activating Fc\u03b3Rs (Fc\u03b3RI, Fc\u03b3RIII, Fc\u03b3RIV) and\/or the inhibitory Fc\u03b3R (Fc\u03b3RIIB). Direct proof for functional expression of Fc\u03b3R by Ag-specific CD8 T cells is lacking. In this article, we show that the majority of memory CD8 T cells generated by bacterial or viral infection express only Fc\u03b3RIIB, and that Fc\u03b3RIIB could be detected on previously activated human CD8 T cells. Of note, Fc\u03b3R stimulation during in vivo Ag challenge not only inhibited the cytotoxicity of memory CD8 T cells against peptide-loaded or virus-infected targets, but Fc\u03b3RIIB blockade during homologous virus challenge enhanced the secondary CD8 T cell response. Thus, memory CD8 T cells intrinsically express a functional Fc\u03b3RIIB, permitting Ag\u2013Ab complexes to regulate secondary CD8 T cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.1302232","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:07:34Z","timestamp":1385597254000},"page":"35-39","source":"Crossref","is-referenced-by-count":55,"title":["Cutting Edge: Expression of Fc\u03b3RIIB Tempers Memory CD8 T Cell Function In Vivo"],"prefix":"10.1093","volume":"192","author":[{"given":"Gabriel R","family":"Starbeck-Miller","sequence":"first","affiliation":[{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir P","family":"Badovinac","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L","family":"Barber","sequence":"additional","affiliation":[{"name":"T Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Harty","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pathology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2025032404071866700_r1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025032404071866700_r2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.0105-2896.2006.00384.x","article-title":"Programming, demarcating, and manipulating CD8+ T-cell memory","volume":"211","author":"Badovinac","year":"2006","journal-title":"Immunol. Rev."},{"key":"2025032404071866700_r3","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.1073\/pnas.101132698","article-title":"Measuring the diaspora for virus-specific CD8+ T cells","volume":"98","author":"Marshall","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032404071866700_r4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nri2251","article-title":"Shaping and reshaping CD8+ T-cell memory","volume":"8","author":"Harty","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025032404071866700_r5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.0105-2896.2006.00385.x","article-title":"T-cell memory and recall responses to respiratory virus infections","volume":"211","author":"Hikono","year":"2006","journal-title":"Immunol. Rev."},{"key":"2025032404071866700_r6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.0105-2896.2006.00393.x","article-title":"Development, trafficking, and function of memory T-cell subsets","volume":"211","author":"Lefran\u00e7ois","year":"2006","journal-title":"Immunol. Rev."},{"key":"2025032404071866700_r7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.it.2011.08.007","article-title":"Targeting B cell responses in universal influenza vaccine design","volume":"32","author":"Kaur","year":"2011","journal-title":"Trends Immunol."},{"key":"2025032404071866700_r8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1086\/589862","article-title":"Vaccines: correlates of vaccine-induced immunity","volume":"47","author":"Plotkin","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"2025032404071866700_r9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1067\/mai.2002.122466","article-title":"Primary immunodeficiency disorders: antibody deficiency","volume":"109","author":"Ballow","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032404071866700_r10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025032404071866700_r11","first-page":"105","article-title":"Fc\u03b3Rs in health and disease","volume":"350","author":"Nimmerjahn","year":"2011","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2025032404071866700_r12","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0952-7915(02)00409-0","article-title":"Fc receptors are major mediators of antibody based inflammation in autoimmunity","volume":"14","author":"Hogarth","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"2025032404071866700_r13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nri856","article-title":"Roles of Fc receptors in autoimmunity","volume":"2","author":"Takai","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025032404071866700_r14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0065-2776(08)60019-X","article-title":"Inhibitory pathways triggered by ITIM-containing receptors","volume":"72","author":"Bolland","year":"1999","journal-title":"Adv. Immunol."},{"key":"2025032404071866700_r15","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.4049\/jimmunol.0900821","article-title":"Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis","volume":"183","author":"Hudrisier","year":"2009","journal-title":"J. Immunol."},{"key":"2025032404071866700_r16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0008-8749(78)90322-2","article-title":"Macrophage\u2014T cell interactions. I. The uptake by T cells of Fc receptors released from macrophages","volume":"40","author":"Lee","year":"1978","journal-title":"Cell. Immunol."},{"key":"2025032404071866700_r17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2010.06.014","article-title":"Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation","volume":"33","author":"Wirth","year":"2010","journal-title":"Immunity"},{"key":"2025032404071866700_r18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(94)90169-4","article-title":"T cell receptor antagonist peptides induce positive selection","volume":"76","author":"Hogquist","year":"1994","journal-title":"Cell"},{"key":"2025032404071866700_r19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/eji.1830170202","article-title":"Characterization of virus-specific cytotoxic T cell clones from allogeneic bone marrow chimeras","volume":"17","author":"Pircher","year":"1987","journal-title":"Eur. J. Immunol."},{"key":"2025032404071866700_r20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fimmu.2011.00004","article-title":"Differential role of \u201cSignal 3\u201d inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo","volume":"2","author":"Pham","year":"2011","journal-title":"Front Immunol"},{"key":"2025032404071866700_r21","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.4049\/jimmunol.166.5.3402","article-title":"Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection","volume":"166","author":"Pope","year":"2001","journal-title":"J. Immunol."},{"key":"2025032404071866700_r22","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/eji.201040310","article-title":"Modulating numbers and phenotype of CD8+ T cells in secondary immune responses","volume":"40","author":"Wirth","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"2025032404071866700_r23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0092-8674(94)90505-3","article-title":"Evidence for a differential avidity model of T cell selection in the thymus","volume":"76","author":"Ashton-Rickardt","year":"1994","journal-title":"Cell"},{"key":"2025032404071866700_r24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.274.5284.94","article-title":"Phenotypic analysis of antigen-specific T lymphocytes","volume":"274","author":"Altman","year":"1996","journal-title":"Science"},{"key":"2025032404071866700_r25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1074-7613(00)80540-3","article-title":"Coordinate regulation of complex T cell populations responding to bacterial infection","volume":"8","author":"Busch","year":"1998","journal-title":"Immunity"},{"key":"2025032404071866700_r26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","article-title":"Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection","volume":"8","author":"Murali-Krishna","year":"1998","journal-title":"Immunity"},{"key":"2025032404071866700_r27","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.immuni.2007.04.013","article-title":"Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection","volume":"26","author":"Badovinac","year":"2007","journal-title":"Immunity"},{"key":"2025032404071866700_r28","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ni804","article-title":"Programmed contraction of CD8(+) T cells after infection","volume":"3","author":"Badovinac","year":"2002","journal-title":"Nat. Immunol."},{"key":"2025032404071866700_r29","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.4049\/jimmunol.0902874","article-title":"Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts","volume":"183","author":"Rai","year":"2009","journal-title":"J. Immunol."},{"key":"2025032404071866700_r30","first-page":"2250","article-title":"Antigen specific killing assay using CFSE labeled target cells","volume":"45","author":"Durward","year":"2010","journal-title":"J. Vis. Exp."},{"key":"2025032404071866700_r31","doi-asserted-by":"crossref","first-page":"e37337","DOI":"10.1371\/journal.pone.0037337","article-title":"Accelerated and improved quantification of lymphocytic choriomeningitis virus (LCMV) titers by flow cytometry","volume":"7","author":"Korns Johnson","year":"2012","journal-title":"PLoS ONE"},{"key":"2025032404071866700_r32","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1084\/jem.150.3.580","article-title":"Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors","volume":"150","author":"Unkeless","year":"1979","journal-title":"J. Exp. Med."},{"key":"2025032404071866700_r33","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.4049\/jimmunol.164.8.4332","article-title":"Expression of a functional high-affinity IgG receptor, Fc gamma RI, on human mast cells: Up-regulation by IFN-gamma","volume":"164","author":"Okayama","year":"2000","journal-title":"J. Immunol."},{"key":"2025032404071866700_r34","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4049\/jimmunol.166.1.531","article-title":"Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines","volume":"166","author":"Pricop","year":"2001","journal-title":"J. Immunol."},{"key":"2025032404071866700_r35","doi-asserted-by":"crossref","first-page":"27535","DOI":"10.1074\/jbc.M200419200","article-title":"Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis","volume":"277","author":"Radeke","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025032404071866700_r36","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.4049\/jimmunol.170.9.4572","article-title":"TGF-beta 1 suppresses [correction of supresses] myeloid Fc gamma receptor function by regulating the expression and function of the common gamma-subunit","volume":"170","author":"Tridandapani","year":"2003","journal-title":"J. Immunol."},{"key":"2025032404071866700_r37","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S1074-7613(00)80074-6","article-title":"SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis","volume":"10","author":"Pearse","year":"1999","journal-title":"Immunity"},{"key":"2025032404071866700_r38","doi-asserted-by":"crossref","first-page":"855","DOI":"10.4049\/jimmunol.133.2.855","article-title":"The blockade of Fc receptor-mediated clearance of immune complexes in vivo by a monoclonal antibody (2.4G2) directed against Fc receptors on murine leukocytes","volume":"133","author":"Kurlander","year":"1984","journal-title":"J. Immunol."},{"key":"2025032404071866700_r39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/vim.2010.0012","article-title":"Both systemic and mucosal LCMV immunization generate robust viral-specific IgG in mucosal secretions, but elicit poor LCMV-specific IgA","volume":"23","author":"Rajini","year":"2010","journal-title":"Viral Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/192\/1\/35\/62513228\/1302232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/192\/1\/35\/62513228\/1302232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:38:07Z","timestamp":1742776687000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/192\/1\/35\/7993577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1302232","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718190030.793493226","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,1]]},"published":{"date-parts":[[2014,1,1]]}}}