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We show that C-type lectin receptors exert divergent contributions to the development of antifungal Th17 cells and vaccine resistance against Blastomyces dermatitidis, Histoplasma capsulatum, and Coccidioides posadasii. Acquired immunity to B. dermatitidis requires Dectin-2, whereas vaccination against H. capsulatum and C. posadasii infection depends on innate sensing by Dectin-1 and Dectin-2, but not Mincle. Tracking Ag-specific T cells in vivo established that the Card9 signaling pathway acts indispensably and exclusively on differentiation of Th17 cells, while leaving intact their activation, proliferation, survival, and migration. Whereas Card9 signaling is essential, C-type lectin receptors offer distinct and divergent contributions to vaccine immunity against these endemic fungal pathogens. Our work provides new insight into innate immune mechanisms that drive vaccine immunity and Th17 cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1302314","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T22:26:41Z","timestamp":1388788001000},"page":"1107-1119","source":"Crossref","is-referenced-by-count":93,"title":["C-Type Lectin Receptors Differentially Induce Th17 Cells and Vaccine Immunity to the Endemic Mycosis of North America"],"prefix":"10.1093","volume":"192","author":[{"given":"Huafeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics , Madison, WI 53792"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"LeBert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics , Madison, WI 53792"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung Yu","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas , San Antonio, TX 78249"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Galles","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics , Madison, WI 53792"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Saijo","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, University of Tokyo , Tokyo 108-8639","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Oncology, University of Texas, M.D. Anderson Cancer Center , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry T","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas , San Antonio, TX 78249"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce S","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics , Madison, WI 53792"},{"name":"Internal Medicine, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics , Madison, WI 53792"},{"name":"Medical Microbiology and Immunology, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics , Madison, WI 53792"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"W\u00fcthrich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics , Madison, WI 53792"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"key":"2025032404110872100_r1","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1172\/JCI11037","article-title":"Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistance","volume":"106","author":"W\u00fcthrich","year":"2000","journal-title":"J. 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