{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:19:54Z","timestamp":1791206394434,"version":"4.1.0"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dynamic interactions between CD4+ T cells and B cells are needed for humoral immunity and CD4+ T cell memory. It is not known whether B cells are needed early on to induce the formation of memory precursor cells or are needed later to sustain memory cells. In this study, primary and memory CD4+ T cells responses were followed in wild-type mice that were depleted of mature B cells by anti-CD20 before or different times after acute lymphocytic choriomeningitis virus infection. The Ab treatment led to a 1000-fold reduction in B cell number that lasted 6 wk. Primary virus-specific CD4+ Th1 cells were generated in B cell\u2013depleted mice; however, there was a decrease in the CD4+Ly6CloTbet+ memory precursor population and a corresponding 4-fold reduction in CD4+ memory cell number. Memory T cells showed impaired cytokine production when they formed without B cells. B cell depletion had no effect on established memory populations. During disseminating virus infection, B cell depletion led to sustained weight loss and functional exhaustion of CD4+ and CD8+ T cells, and prevented mice from resolving the infection. Thus, B cells contribute to the establishment and survival of memory CD4+ T cells post\u2013acute infection and play an essential role in immune protection against disseminating virus infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1302661","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T04:55:34Z","timestamp":1390452934000},"page":"1597-1608","source":"Crossref","is-referenced-by-count":57,"title":["B Cell Depletion Curtails CD4+ T Cell Memory and Reduces Protection against Disseminating Virus Infection"],"prefix":"10.1093","volume":"192","author":[{"given":"Ichiro","family":"Misumi","sequence":"first","affiliation":[{"name":"Department of Genetics, The University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason K","family":"Whitmire","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, NC 27599"},{"name":"Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,15]]},"reference":[{"key":"2025032404145067400_r1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1097\/INF.0b013e31815a044f","article-title":"Monoclonal antibody therapeutics and risk for infection","volume":"26","author":"Gea-Banacloche","year":"2007","journal-title":"Pediatr. 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