{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:18:37Z","timestamp":1790601517634,"version":"4.1.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although resistin was recently found to modulate insulin resistance in preclinical models of type II diabetes and obesity, recent studies also suggested that resistin has proinflammatory properties. We examined whether the human-specific variant of resistin affects neutrophil activation and the severity of LPS-induced acute lung injury. Because human and mouse resistin have distinct patterns of tissue distribution, experiments were performed using humanized resistin mice that exclusively express human resistin (hRTN+\/\u2212\/\u2212) but are deficient in mouse resistin. Enhanced production of TNF-\u03b1 or MIP-2 was found in LPS-treated hRtn+\/\u2212\/\u2212 neutrophils compared with control Rtn\u2212\/\u2212\/\u2212 neutrophils. Expression of human resistin inhibited the activation of AMP-activated protein kinase, a major sensor and regulator of cellular bioenergetics that also is implicated in inhibiting inflammatory activity of neutrophils and macrophages. In addition to the ability of resistin to sensitize neutrophils to LPS stimulation, human resistin enhanced neutrophil extracellular trap formation. In LPS-induced acute lung injury, humanized resistin mice demonstrated enhanced production of proinflammatory cytokines, more severe pulmonary edema, increased neutrophil extracellular trap formation, and elevated concentration of the alarmins HMGB1 and histone 3 in the lungs. Our results suggest that human resistin may play an important contributory role in enhancing TLR4-induced inflammatory responses, and it may be a target for future therapies aimed at reducing the severity of acute lung injury and other inflammatory situations in which neutrophils play a major role.<\/jats:p>","DOI":"10.4049\/jimmunol.1302764","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T23:28:12Z","timestamp":1397086092000},"page":"4795-4803","source":"Crossref","is-referenced-by-count":85,"title":["Human Resistin Promotes Neutrophil Proinflammatory Activation and Neutrophil Extracellular Trap Formation and Increases Severity of Acute Lung Injury"],"prefix":"10.1093","volume":"192","author":[{"given":"Shaoning","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham , Birmingham, AL 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham , Birmingham, AL 35294"},{"name":"Division of Infectious Diseases, Korea University Ansan Hospital , Ansan 425-707,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Tadie","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham , Birmingham, AL 35294"},{"name":"Service des Maladies Infectieuses et R\u00e9animation M\u00e9dicale, Centre Hospitalier Universitaire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle","family":"Gregoire","sequence":"additional","affiliation":[{"name":"INSERM, Unite Mixte de Recherche U917, Universit\u00e9 de Rennes 1 , Rennes 35033,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessy","family":"Deshane","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham , Birmingham, AL 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Francois","family":"Pittet","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Alabama at Birmingham , Birmingham, AL 35294-0012"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Abraham","sequence":"additional","affiliation":[{"name":"Office of the Dean, Wake Forest University School of Medicine , Winston-Salem, NC 27157"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw W","family":"Zmijewski","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham , Birmingham, AL 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"2025032404301715500_r1","first-page":"259","article-title":"Human resistin: found in translation from mouse to man","volume":"22","author":"Schwartz","year":"2011","journal-title":"Trends Endocrinol. 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