{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:25:08Z","timestamp":1768317908916,"version":"3.49.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The female genital tract is a portal of entry for sexual HIV transmission and a possible viral reservoir. In this study, the ectocervical CD8+ T cell distribution was explored in situ and was related to expression of CD3 and HLA-DR and presence of HIV RNA. For this purpose, ectocervical tissue samples and genital secretions were collected from HIV-seropositive (HIV+) Kenyan female sex workers (FSWs) (n = 20), HIV-seronegative (HIV\u2212) FSWs (n = 17), and HIV\u2212 lower-risk women (n = 21). Cell markers were assessed by in situ staining and by quantitative PCR. HIV RNA expression in tissue was analyzed by in situ hybridization, and viral shedding was assessed by quantitative PCR. The HIV+FSW group had a higher amount of total cells and CD8+, CD3+, and HLA-DR+ cells compared with the HIV\u2212FSW group and HIV\u2212 lower-risk women. The majority of CD8+ cells were CD3+ T cells, and the numbers of CD8+ cells correlated significantly with plasma and cervical viral load. HIV RNA expression in situ was found in 4 of the 20 HIV+FSW women but did not correlate with cervical or plasma viral load. Thus, the HIV+ women displayed high numbers of CD8+, CD3+, and HLA-DR+ cells, as well as a limited number of HIV RNA+ cells, in their ectocervical mucosa; hence, this localization cannot be neglected as a potential viral reservoir. The elevated levels of CD8+ T cells may play a role in the immunopathogenesis of HIV in the female genital tract.<\/jats:p>","DOI":"10.4049\/jimmunol.1302826","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T05:36:36Z","timestamp":1395120996000},"page":"3947-3957","source":"Crossref","is-referenced-by-count":13,"title":["Presence of CD8+ T Cells in the Ectocervical Mucosa Correlates with Genital Viral Shedding in HIV-Infected Women despite a Low Prevalence of HIV RNA\u2013Expressing Cells in the Tissue"],"prefix":"10.1093","volume":"192","author":[{"given":"Anna","family":"Gibbs","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital , 17176 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha","family":"Hirbod","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital , 17176 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Nebraska Center for Virology, University of Nebraska-Lincoln , Lincoln, NE 68583"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Bohman","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital , 17176 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry B","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Manitoba , Winnipeg, Manitoba R3E 0J9,","place":["Canada"]},{"name":"National Microbiology Laboratory, Public Health Agency of Canada , Winnipeg, Manitoba R3E 3R2,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis A","family":"Plummer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Manitoba , Winnipeg, Manitoba R3E 0J9,","place":["Canada"]},{"name":"National Microbiology Laboratory, Public Health Agency of Canada , Winnipeg, Manitoba R3E 3R2,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupert","family":"Kaul","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Toronto , Toronto, Ontario M5S 1A8,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Kimani","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Nairobi , 00100 Nairobi,","place":["Kenya"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Broliden","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital , 17176 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelie","family":"Tjernlund","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital , 17176 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"issue":"1","key":"2025032404245164100_r1","first-page":"e746","article-title":"Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract","volume":"128","author":"Nkwanyana","year":"2009","journal-title":"Immunology"},{"key":"2025032404245164100_r2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1084\/jem.185.2.293","article-title":"HIV-1 induces cytotoxic T lymphocytes in the cervix of infected women","volume":"185","author":"Musey","year":"1997","journal-title":"J. Exp. Med."},{"key":"2025032404245164100_r3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/imm.12084","article-title":"HIV-specific T-cell responses detected in the genital tract of chronically HIV-infected women are largely monofunctional","volume":"139","author":"Bere","year":"2013","journal-title":"Immunology"},{"key":"2025032404245164100_r4","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1128\/JVI.05671-11","article-title":"CD4 T cell depletion at the cervix during HIV infection is associated with accumulation of terminally differentiated T cells","volume":"85","author":"Gumbi","year":"2011","journal-title":"J. Virol."},{"key":"2025032404245164100_r5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/00002030-199606001-00010","article-title":"The distribution of immunocompetent cells in the genital tract of HIV-positive women","volume":"10","author":"Olaitan","year":"1996","journal-title":"AIDS"},{"key":"2025032404245164100_r6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1086\/590503","article-title":"Relationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection","volume":"198","author":"Bebell","year":"2008","journal-title":"J. Infect. Dis."},{"key":"2025032404245164100_r7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/infdis\/jir715","article-title":"Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women","volume":"205","author":"Roberts","year":"2012","journal-title":"J. Infect. Dis."},{"key":"2025032404245164100_r8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tim.2013.02.002","article-title":"Missing out on the biology of heterosexual HIV-1 transmission","volume":"21","author":"Southern","year":"2013","journal-title":"Trends Microbiol."},{"key":"2025032404245164100_r9","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.4049\/jimmunol.1301220","article-title":"Stable CD4 expression and local immune activation in the ectocervical mucosa of HIV-infected women","volume":"191","author":"Hirbod","year":"2013","journal-title":"J. Immunol."},{"key":"2025032404245164100_r10","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1056\/NEJM200003303421303","article-title":"Viral load and heterosexual transmission of human immunodeficiency virus type 1","volume":"342","author":"Quinn","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"2025032404245164100_r11","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/01.qai.0000229997.52246.95","article-title":"Association between paired plasma and cervicovaginal lavage fluid HIV-1 RNA levels during 36 months","volume":"42","author":"Cu-Uvin","year":"2006","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"2025032404245164100_r12","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/S0140-6736(01)06653-3","article-title":"Determinants of HIV-1 shedding in the genital tract of women","volume":"358","author":"Kovacs","year":"2001","journal-title":"Lancet"},{"key":"2025032404245164100_r13","first-page":"S11","article-title":"Prevalence and correlates of HIV type 1 shedding in the female genital tract","volume":"14","author":"Mostad","year":"1998","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"2025032404245164100_r14","doi-asserted-by":"crossref","first-page":"77ra29","DOI":"10.1126\/scitranslmed.3001888","article-title":"Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission","volume":"3","author":"Baeten","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"2025032404245164100_r15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2174\/1570162033352110","article-title":"Measuring the infectiousness of persons with HIV-1: opportunities for preventing sexual HIV-1 transmission","volume":"1","author":"Baeten","year":"2003","journal-title":"Curr. HIV Res."},{"key":"2025032404245164100_r16","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/QAI.0b013e31826c2edd","article-title":"Genital Inflammation Predicts HIV-1 Shedding Independent of Plasma Viral Load and Systemic Inflammation","volume":"61","author":"Blish","year":"2012","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"2025032404245164100_r17","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1089\/aid.2011.0394","article-title":"Genital tract viral load in HIV Type 1-positive women correlates with specific cytokine levels in cervical-vaginal secretions but is not a determinant of infectious virus or anti-HIV activity","volume":"28","author":"Mukura","year":"2012","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"2025032404245164100_r18","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1086\/592303","article-title":"Genital tract leukocytes and shedding of genital HIV type 1 RNA","volume":"47","author":"Anderson","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"2025032404245164100_r19","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1086\/593214","article-title":"Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2\/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial","volume":"198","author":"Baeten","year":"2008","journal-title":"J. Infect. Dis."},{"key":"2025032404245164100_r20","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1097\/OLQ.0b013e31811ec7cb","article-title":"Frequent douching and clinical outcomes among HIV-infected women","volume":"34","author":"Clark","year":"2007","journal-title":"Sex. Transm. Dis."},{"key":"2025032404245164100_r21","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1001\/jama.1993.03500220046024","article-title":"Detection of HIV DNA in cervical and vaginal secretions. Prevalence and correlates among women in Nairobi, Kenya","volume":"269","author":"Clemetson","year":"1993","journal-title":"JAMA"},{"key":"2025032404245164100_r22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1473-3099(11)70247-X","article-title":"Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study","volume":"12","author":"Heffron","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"2025032404245164100_r23","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/OLQ.0b013e3181812d15","article-title":"The effect of genital tract infections on HIV-1 shedding in the genital tract: a systematic review and meta-analysis","volume":"35","author":"Johnson","year":"2008","journal-title":"Sex. Transm. Dis."},{"key":"2025032404245164100_r24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00002030-200101050-00015","article-title":"Treatment of cervicitis is associated with decreased cervical shedding of HIV-1","volume":"15","author":"Mcclelland","year":"2001","journal-title":"AIDS"},{"key":"2025032404245164100_r25","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1097\/00002030-200212060-00007","article-title":"Association between cervical shedding of herpes simplex virus and HIV-1","volume":"16","author":"McClelland","year":"2002","journal-title":"AIDS"},{"key":"2025032404245164100_r26","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJMoa062607","article-title":"Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus","volume":"356","author":"Nagot","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"2025032404245164100_r27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jri.2012.10.010","article-title":"Innate and adaptive anti-HIV immune responses in the female reproductive tract","volume":"97","author":"Rodriguez-Garcia","year":"2013","journal-title":"J. Reprod. Immunol."},{"key":"2025032404245164100_r28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00002030-200401230-00009","article-title":"The effect of hormonal contraception on genital tract shedding of HIV-1","volume":"18","author":"Wang","year":"2004","journal-title":"AIDS"},{"key":"2025032404245164100_r29","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1097\/QAD.0b013e32833e5043","article-title":"Genital tract HIV-1 RNA shedding among women with below detectable plasma viral load","volume":"24","author":"Cu-Uvin","year":"2010","journal-title":"AIDS"},{"key":"2025032404245164100_r30","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1001\/jama.282.17.1627","article-title":"Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy","volume":"282","author":"Dornadula","year":"1999","journal-title":"JAMA"},{"key":"2025032404245164100_r31","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00002030-200303070-00001","article-title":"Recent observations on HIV type-1 infection in the genital tract of men and women","volume":"17","author":"Coombs","year":"2003","journal-title":"AIDS"},{"key":"2025032404245164100_r32","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1086\/432482","article-title":"Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers","volume":"192","author":"Iqbal","year":"2005","journal-title":"J. Infect. Dis."},{"key":"2025032404245164100_r33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/QAI.0b013e3180415da7","article-title":"Proinflammatory and type 1 cytokine expression in cervical mucosa during HIV-1 and human papillomavirus infection","volume":"45","author":"Behbahani","year":"2007","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"2025032404245164100_r34","first-page":"40","article-title":"In situ detection of PCR-amplified HIV-1 nucleic acids and tumor necrosis factor cDNA in cervical tissues","volume":"143","author":"Nuovo","year":"1993","journal-title":"Am. J. Pathol."},{"key":"2025032404245164100_r35","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1046\/j.1365-2249.1998.00561.x","article-title":"Changes to the cytokine microenvironment in the genital tract mucosa of HIV+ women","volume":"112","author":"Olaitan","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"2025032404245164100_r36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.7326\/0003-4819-108-3-321","article-title":"Human immunodeficiency virus (HIV) infection of the uterine cervix","volume":"108","author":"Pomerantz","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"2025032404245164100_r37","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1097\/00002030-200011100-00016","article-title":"Risk factors for postnatal mother-child transmission of HIV-1","volume":"14","author":"Embree","year":"2000","journal-title":"AIDS"},{"key":"2025032404245164100_r38","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0140-6736(95)12269-2","article-title":"Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya","volume":"348","author":"Fowke","year":"1996","journal-title":"Lancet"},{"key":"2025032404245164100_r39","doi-asserted-by":"crossref","first-page":"e47570","DOI":"10.1371\/journal.pone.0047570","article-title":"Feasibility and safety of cervical biopsy sampling for mucosal immune studies in female sex workers from Nairobi, Kenya","volume":"7","author":"Hasselrot","year":"2012","journal-title":"PLoS ONE"},{"key":"2025032404245164100_r40","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/nature03513","article-title":"Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells","volume":"434","author":"Li","year":"2005","journal-title":"Nature"},{"key":"2025032404245164100_r41","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1086\/381396","article-title":"Functional genomic analysis of the response of HIV-1-infected lymphatic tissue to antiretroviral therapy","volume":"189","author":"Li","year":"2004","journal-title":"J. Infect. Dis."},{"key":"2025032404245164100_r42","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.3892\/ijo_00000810","article-title":"Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women","volume":"37","author":"Brismar Wendel","year":"2010","journal-title":"Int. J. Oncol."},{"key":"2025032404245164100_r43","doi-asserted-by":"crossref","first-page":"F123","DOI":"10.1097\/00002030-199811000-00004","article-title":"Early reduction of immune activation in lymphoid tissue following highly active HIV therapy","volume":"12","author":"Andersson","year":"1998","journal-title":"AIDS"},{"key":"2025032404245164100_r44","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.2353\/ajpath.2010.090926","article-title":"Abundant expression of HIV target cells and C-type lectin receptors in the foreskin tissue of young Kenyan men","volume":"176","author":"Hirbod","year":"2010","journal-title":"Am. J. Pathol."},{"key":"2025032404245164100_r45","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/jlb.59.2.287","article-title":"Computerized assessment of production of multiple human cytokines at the single-cell level using image analysis","volume":"59","author":"Bjork","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"2025032404245164100_r46","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri3442","article-title":"The integration of T cell migration, differentiation and function","volume":"13","author":"Masopust","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025032404245164100_r47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-immunol-032712-095954","article-title":"Memory T cell subsets, migration patterns, and tissue residence","volume":"31","author":"Mueller","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"2025032404245164100_r48","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/infdis\/jir591","article-title":"Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding","volume":"204","author":"Jaspan","year":"2011","journal-title":"J. Infect. Dis."},{"key":"2025032404245164100_r49","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fimmu.2013.00298","article-title":"Immune Activation and Collateral Damage in AIDS Pathogenesis","volume":"4","author":"Miedema","year":"2013","journal-title":"Front. Immunol."},{"key":"2025032404245164100_r50","article-title":"Serial cervicovaginal exposures with replication-deficient sivsm induce higher dendritic cell (pdc) and cd4+ t-cell infiltrates not associated with prevention but a more severe sivmac251 infection of rhesus macaques","volume-title":"J. Acquir. Immune Defic. Syndr.","author":"Abdulhaqq","year":"2013"},{"key":"2025032404245164100_r51","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/nature07831","article-title":"Glycerol monolaurate prevents mucosal SIV transmission","volume":"458","author":"Li","year":"2009","journal-title":"Nature"},{"key":"2025032404245164100_r52","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1086\/322780","article-title":"Chronic inflammation with increased human immunodeficiency virus (HIV) RNA expression in the vaginal epithelium of HIV-infected Thai women","volume":"184","author":"Cohn","year":"2001","journal-title":"J. Infect. Dis."},{"key":"2025032404245164100_r53","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.274.5289.985","article-title":"Quantitative image analysis of HIV-1 infection in lymphoid tissue","volume":"274","author":"Haase","year":"1996","journal-title":"Science"},{"key":"2025032404245164100_r54","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1086\/597801","article-title":"Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells","volume":"199","author":"Card","year":"2009","journal-title":"J. Infect. Dis."},{"key":"2025032404245164100_r55","doi-asserted-by":"crossref","first-page":"e43670","DOI":"10.1371\/journal.pone.0043670","article-title":"Blunted IL17\/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV-exposed, seronegative female sex workers in Kenya","volume":"7","author":"Chege","year":"2012","journal-title":"PLoS ONE"},{"key":"2025032404245164100_r56","doi-asserted-by":"crossref","first-page":"S339","DOI":"10.1086\/655968","article-title":"HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors","volume":"202","author":"McLaren","year":"2010","journal-title":"J. Infect. Dis."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/192\/8\/3947\/61760236\/1302826.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/192\/8\/3947\/61760236\/1302826.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T08:41:42Z","timestamp":1742805702000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/192\/8\/3947\/8001585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1302826","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,4]]},"published":{"date-parts":[[2014,4]]}}}