{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:32:28Z","timestamp":1791772348612,"version":"4.3.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cancer progression is associated with inflammation, increased metabolic demand, infection, cachexia, and eventually death. Myeloid-derived suppressor cells (MDSCs) commonly expand during cancer and are associated with adaptive immune suppression and inflammatory metabolite production. We propose that cancer-induced cachexia is driven at least in part by the expansion of MDSCs. MDSC expansion in 4T1 mammary carcinoma-bearing hosts is associated with induction of a hepatic acute-phase protein response and altered host energy and fat metabolism, and eventually reduced survival to polymicrobial sepsis and endotoxemia. Similar results are also seen in mice bearing a Lewis lung carcinoma and a C26 colon adenocarcinoma. However, a similar cachexia response is not seen with equivalent growth of the 66C4 subclone of 4T1, in which MDSC expansion does not occur. Importantly, reducing MDSC numbers in 4T1-bearing animals can ameliorate some of these late responses and reduce susceptibility to inflammation-induced organ injury and death. In addition, administering MDSCs from both tumor- and nontumor-bearing mice can produce an acute-phase response. Thus, we propose a previously undescribed mechanism for the development of cancer cachexia, whereby progressive MDSC expansion contributes to changes in host protein and energy metabolism and reduced resistance to infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1302895","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T03:11:36Z","timestamp":1400123496000},"page":"6111-6119","source":"Crossref","is-referenced-by-count":67,"title":["Novel Role for Tumor-Induced Expansion of Myeloid-Derived Cells in Cancer Cachexia"],"prefix":"10.1093","volume":"192","author":[{"given":"Alex G","family":"Cuenca","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L","family":"Cuenca","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D","family":"Winfield","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallas N","family":"Joiner","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Delano","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kindra M","family":"Kelly-Scumpia","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip O","family":"Scumpia","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K","family":"Matheny","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Scarpace","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizette","family":"Vila","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A","family":"Efron","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drake M","family":"LaFace","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories (formerly DNAX Research Institute) , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle L","family":"Moldawer","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida College of Medicine , Gainesville, FL 32610"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,15]]},"reference":[{"key":"2025032404333311500_r1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"2025032404333311500_r2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/0148607108325075","article-title":"Myeloid-derived suppressor cells in cancer cachexia syndrome: a new explanation for an old problem","volume":"32","author":"Winfield","year":"2008","journal-title":"JPEN J. 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