{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:19:57Z","timestamp":1790543997060,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Enhancement of intestinal IgA responses is a primary strategy in the development of oral vaccine. Dietary fatty acids are known to regulate host immune responses. In this study, we show that dietary palmitic acid (PA) and its metabolites enhance intestinal IgA responses. Intestinal IgA production was increased in mice maintained on a PA-enriched diet. These mice also showed increased intestinal IgA responses against orally immunized Ag, without any effect on serum Ab responses. We found that PA directly stimulates plasma cells to produce Ab. In addition, mice receiving a PA-enriched diet had increased numbers of IgA-producing plasma cells in the large intestine; this effect was abolished when serine palmitoyltransferase was inhibited. These findings suggest that dietary PA regulates intestinal IgA responses and has the potential to be a diet-derived mucosal adjuvant.<\/jats:p>","DOI":"10.4049\/jimmunol.1302944","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T04:12:40Z","timestamp":1405570360000},"page":"1666-1671","source":"Crossref","is-referenced-by-count":64,"title":["Regulation of Intestinal IgA Responses by Dietary Palmitic Acid and Its Metabolism"],"prefix":"10.1093","volume":"193","author":[{"given":"Jun","family":"Kunisawa","sequence":"first","affiliation":[{"name":"Laboratory of Vaccine Materials, National Institute of Biomedical Innovation , Osaka 567-0085 ,","place":["Japan"]},{"name":"Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Department of Microbiology and Immunology, Kobe University School of Medicine , Kobe 650-0017 ,","place":["Japan"]},{"name":"Graduate School of Pharmaceutical Sciences and Graduate School of Dentistry, Osaka University , Osaka 565-0871 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, National Institute of Biomedical Innovation , Osaka 567-0085 ,","place":["Japan"]},{"name":"Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Inoue","sequence":"additional","affiliation":[{"name":"International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University , Sendai 980-8578 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, National Institute of Biomedical Innovation , Osaka 567-0085 ,","place":["Japan"]},{"name":"Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo , Tokyo 108-8639 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of Medical Science, University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency , Saitama 332-0012 ,","place":["Japan"]},{"name":"Department of Medical Genome Science, Graduate School of Frontier Science, University of Tokyo , Chiba 277-8561 ,","place":["Japan"]},{"name":"Graduate School of Medicine, University of Tokyo , Tokyo 113-0033 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"2025030707284869800_r1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/mi.2007.6","article-title":"The immune geography of IgA induction and function","volume":"1","author":"Macpherson","year":"2008","journal-title":"Mucosal Immunol."},{"key":"2025030707284869800_r2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/path.1877","article-title":"The function of 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