{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:23:47Z","timestamp":1792715027120,"version":"4.5.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Psoriasis is an inflammatory skin disease with accelerated epidermal cell turnover. Neutrophil accumulation in the skin is one of the histological characteristics of psoriasis. However, the precise mechanism and role of neutrophil infiltration remain largely unknown. In this article, we show that orchestrated action of CXCR2 and leukotriene B4 receptor BLT1 plays a key role in neutrophil recruitment during the development of imiquimod (IMQ)-induced psoriatic skin lesions in mice. Depletion of neutrophils with anti\u2013Ly-6G Ab ameliorated the disease severity, along with reduced expression of proinflammatory cytokine IL-1\u03b2 in the skin. Furthermore, CXCR2 and BLT1 coordinately promote neutrophil infiltration into the skin during the early phase of IMQ-induced inflammation. In vitro, CXCR2 ligands augment leukotriene B4 production by murine neutrophils, which, in turn, amplifies chemokine-mediated neutrophil chemotaxis via BLT1 in autocrine and\/or paracrine manners. In agreement with the increased IL-19 expression in IMQ-treated mouse skin, IL-1\u03b2 markedly upregulated expression of acanthosis-inducing cytokine IL-19 in human keratinocytes. We propose that coordination of chemokines, lipids, and cytokines with multiple positive feedback loops might drive the pathogenesis of psoriasis and, possibly, other inflammatory diseases as well. Interference to this positive feedback or its downstream effectors could be targets of novel anti-inflammatory treatment.<\/jats:p>","DOI":"10.4049\/jimmunol.1302959","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T05:39:59Z","timestamp":1395725999000},"page":"4361-4369","source":"Crossref","is-referenced-by-count":147,"title":["Interplay between CXCR2 and BLT1 Facilitates Neutrophil Infiltration and Resultant Keratinocyte Activation in a Murine Model of Imiquimod-Induced Psoriasis"],"prefix":"10.1093","volume":"192","author":[{"given":"Hayakazu","family":"Sumida","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033,","place":["Japan"]},{"name":"Department of Dermatology, Faculty of Medicine, The University of Tokyo , Tokyo 113-8655,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033,","place":["Japan"]},{"name":"Department of Lipid Signaling, National Center for Global Health and Medicine , Tokyo 166-8655,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033,","place":["Japan"]},{"name":"Department of Lipidomics, Faculty of Medicine, The University of Tokyo , Tokyo 113-0033,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo , Tokyo 113-0033,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo , Tokyo 113-0033,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonao","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, The University of Tokyo , Tokyo 113-8655,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033,","place":["Japan"]},{"name":"Department of Lipid Signaling, National Center for Global Health and Medicine , Tokyo 166-8655,","place":["Japan"]},{"name":"Department of Lipidomics, Faculty of Medicine, The University of Tokyo , Tokyo 113-0033,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"2025032404252243600_r1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev-pathol-011811-132448","article-title":"Psoriasis","volume":"7","author":"Perera","year":"2012","journal-title":"Annu. 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