{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T09:22:09Z","timestamp":1775985729229,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Wnt-responsive transcription factor T cell factor 1 (Tcf1) is well known for its role in thymic T cell development and the formation of memory CD8+ T cells. However, its role in the initial phases of CD8+ T effector cell formation has remained unexplored. We report that high levels of Wnt signaling and Tcf1 are operational in naive and memory CD8+ T cells, whereas Wnt signaling and Tcf1 were low in effector CD8+ T cells. CD8+ T cells deficient in Tcf1 produce IFN-\u03b3 more rapidly, coinciding with increased demethylation of the IFN-\u03b3 enhancer and higher expression of the transcription factors Tbet and Blimp1. Moreover, virus-specific Tcf1\u2212\/\u2212 CD8+ T cells show accelerated expansion in acute infection, which is associated with increased IFN-\u03b3 and TNF production and lower viral load. Genetic complementation experiments with various Tcf1 isoforms indicate that Tcf1 dosage and protein stability are critical in suppressing IFN-\u03b3 production. Isoforms lacking the \u03b2-catenin binding domain are equally effective in inhibiting CD8+ effector T cell formation. Thus, Tcf1 functions as a repressor of CD8+ effector T cell formation in a \u03b2-catenin\/Wnt-independent manner.<\/jats:p>","DOI":"10.4049\/jimmunol.1303417","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T03:03:14Z","timestamp":1414638194000},"page":"5480-5487","source":"Crossref","is-referenced-by-count":51,"title":["T Cell Factor 1 Represses CD8+ Effector T Cell Formation and Function"],"prefix":"10.1093","volume":"193","author":[{"given":"Machteld M","family":"Tiemessen","sequence":"first","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center , 2300 RC\/Leiden ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda R M","family":"Baert","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center , 2300 RC\/Leiden ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianne","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center , 2300 RC\/Leiden ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja C J A","family":"van Eggermond","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center , 2300 RC\/Leiden ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"van den Elsen","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center , 2300 RC\/Leiden ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Arens","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center , 2300 RC\/Leiden ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J T","family":"Staal","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Leiden University Medical Center , 2300 RC\/Leiden ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,12,1]]},"reference":[{"key":"2025030707482643300_r1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. 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