{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:29:17Z","timestamp":1791178157733,"version":"4.1.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chlamydia trachomatis is considered the most common agent of sexually transmitted disease worldwide. As an obligate intracellular bacterium, it relies on the host for survival. Production of NO is an effective antimicrobial defense mechanism of the innate immune system. However, whether NO is able to arrest chlamydial growth remains unclear. Similarly, little is known about the mechanisms underlying subversion of cellular innate immunity by C. trachomatis. By analyzing protein and mRNA expression in infected human mesenchymal stem cells, combined with RNA interference and biochemical assays, we observed that infection with C. trachomatis led to downregulated expression of inducible NO synthase (iNOS) in human mesenchymal stem cells in vitro. Furthermore, infection upregulated the expression of the rate-limiting enzyme in the polyamine biosynthetic pathway, ornithine decarboxylase, diverting the iNOS substrate l-arginine toward the synthesis of polyamines. Inhibition of ornithine decarboxylase activity using small interfering RNA or the competitive inhibitor difluoromethylornithine restored iNOS protein expression and activity in infected cells and inhibited chlamydial growth. This inhibition was mediated through tyrosine nitration of chlamydial protein by peroxynitrite, an NO metabolite. Thus, Chlamydia evades innate immunity by inhibiting NO production through induction of the alternative polyamine pathway.<\/jats:p>","DOI":"10.4049\/jimmunol.1400377","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T03:14:31Z","timestamp":1407813271000},"page":"2941-2951","source":"Crossref","is-referenced-by-count":26,"title":["<i>Chlamydia trachomatis<\/i> Inhibits Inducible NO Synthase in Human Mesenchymal Stem Cells by Stimulating Polyamine Synthesis"],"prefix":"10.1093","volume":"193","author":[{"given":"Mohammad","family":"Abu-Lubad","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Max Planck Institute for Infection Biology , 10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Max Planck Institute for Infection Biology , 10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir A","family":"Al-Zeer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Max Planck Institute for Infection Biology , 10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"2025030707341217800_r1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.idc.2009.10.002","article-title":"Chlamydophila pneumoniae","volume":"24","author":"Burillo","year":"2010","journal-title":"Infect. Dis. Clin. North Am."},{"key":"2025030707341217800_r2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1542\/pir.25.2.43","article-title":"Chlamydia trachomatis and Chlamydia pneumoniae infections in children and adolescents","volume":"25","author":"Hammerschlag","year":"2004","journal-title":"Pediatr. Rev."},{"key":"2025030707341217800_r3","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.femsre.2005.03.002","article-title":"The chlamydial developmental cycle","volume":"29","author":"Abdelrahman","year":"2005","journal-title":"FEMS Microbiol. Rev."},{"key":"2025030707341217800_r4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1462-5822.2000.00059.x","article-title":"Intracellular survival by Chlamydia","volume":"2","author":"Wyrick","year":"2000","journal-title":"Cell. Microbiol."},{"key":"2025030707341217800_r5","doi-asserted-by":"crossref","first-page":"e16783","DOI":"10.1371\/journal.pone.0016783","article-title":"Chlamydia species-dependent differences in the growth requirement for lysosomes","volume":"6","author":"Ouellette","year":"2011","journal-title":"PLoS ONE"},{"key":"2025030707341217800_r6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1084\/jem.187.4.487","article-title":"Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation","volume":"187","author":"Fan","year":"1998","journal-title":"J. Exp. Med."},{"key":"2025030707341217800_r7","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1084\/jem.191.9.1525","article-title":"Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in chlamydia-infected cells","volume":"191","author":"Zhong","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025030707341217800_r8","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrmicro1007","article-title":"Chlamydia and apoptosis: life and death decisions of an intracellular pathogen","volume":"2","author":"Byrne","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"2025030707341217800_r9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.cellbio.18.012502.105845","article-title":"The chlamydial inclusion: escape from the endocytic pathway","volume":"18","author":"Fields","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2025030707341217800_r10","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0952-7915(02)00361-8","article-title":"The role of IFN-gamma in the outcome of chlamydial infection","volume":"14","author":"Rottenberg","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"2025030707341217800_r11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0891-5849(98)00094-X","article-title":"Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease","volume":"25","author":"Grisham","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"2025030707341217800_r12","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1084\/jem.187.6.917","article-title":"Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock","volume":"187","author":"Hierholzer","year":"1998","journal-title":"J. Exp. Med."},{"key":"2025030707341217800_r13","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1016\/0006-2952(81)90270-7","article-title":"Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections","volume":"30","author":"Nathan","year":"1981","journal-title":"Biochem. Pharmacol."},{"key":"2025030707341217800_r14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"2025030707341217800_r15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"2025030707341217800_r16","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1073\/pnas.97.16.8841","article-title":"Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens","volume":"97","author":"Nathan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707341217800_r17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1254\/jphs.CRJ05004X","article-title":"Nitric oxide-induced nitrative stress involved in microbial pathogenesis","volume":"98","author":"Zaki","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"2025030707341217800_r18","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1139\/w05-080","article-title":"Effect of nitric oxide on the growth of Chlamydophila pneumoniae","volume":"51","author":"Carratelli","year":"2005","journal-title":"Can. J. Microbiol."},{"key":"2025030707341217800_r19","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1097\/00005344-199204002-00016","article-title":"Nitric oxide synthase-catalyzed activation of oxygen and reduction of cytochromes: reaction mechanisms and possible physiological implications","volume":"20","author":"Mayer","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2025030707341217800_r20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1574-695X.1996.tb00277.x","article-title":"Nitric oxide production: a mechanism of Chlamydia trachomatis inhibition in interferon-gamma-treated RAW264.7 cells","volume":"14","author":"Chen","year":"1996","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"2025030707341217800_r21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1006\/bbrc.1997.6335","article-title":"Inhibition of intracellular multiplication of human strains of Chlamydia trachomatis by nitric oxide","volume":"232","author":"Igietseme","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030707341217800_r22","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/jlb.59.5.656","article-title":"Integrin-mediated epithelial-T cell interaction enhances nitric oxide production and increased intracellular inhibition of Chlamydia","volume":"59","author":"Igietseme","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"2025030707341217800_r23","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1128\/IAI.66.4.1282-1286.1998","article-title":"Chlamydial infection in inducible nitric oxide synthase knockout mice","volume":"66","author":"Igietseme","year":"1998","journal-title":"Infect. Immun."},{"key":"2025030707341217800_r24","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1128\/IAI.66.2.835-838.1998","article-title":"Inducible nitric oxide synthase does not affect resolution of murine chlamydial genital tract infections or eradication of chlamydiae in primary murine cell culture","volume":"66","author":"Ramsey","year":"1998","journal-title":"Infect. Immun."},{"key":"2025030707341217800_r25","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.4049\/jimmunol.1102764","article-title":"Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract","volume":"188","author":"Johnson","year":"2012","journal-title":"J. Immunol."},{"key":"2025030707341217800_r26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1479-5876-7-46","article-title":"Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures","volume":"7","author":"Jazedje","year":"2009","journal-title":"J. Transl. Med."},{"key":"2025030707341217800_r27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4161\/auto.22482","article-title":"Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins","volume":"9","author":"Al-Zeer","year":"2013","journal-title":"Autophagy"},{"key":"2025030707341217800_r28","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/01.HYP.0000146907.82869.f2","article-title":"Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles","volume":"44","author":"Zhang","year":"2004","journal-title":"Hypertension"},{"key":"2025030707341217800_r29","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.4049\/jimmunol.163.7.3771","article-title":"Th1\/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells","volume":"163","author":"Munder","year":"1999","journal-title":"J. Immunol."},{"key":"2025030707341217800_r30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0003-2697(91)90273-V","article-title":"An ion-exchange chromatography procedure for the isolation and concentration of basic amino acids and polyamines from complex biological samples prior to high-performance liquid chromatography","volume":"199","author":"Gilbert","year":"1991","journal-title":"Anal. Biochem."},{"key":"2025030707341217800_r31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0021-9673(94)00938-6","article-title":"Use of chromogenic and fluorescent oxycarbonyl chlorides as reagents for amino acid analysis by high-performance liquid chromatography","volume":"697","author":"Br\u00fcckner","year":"1995","journal-title":"J. Chromatogr. A"},{"key":"2025030707341217800_r32","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1095\/biolreprod.103.024109","article-title":"Clonogenicity of human endometrial epithelial and stromal cells","volume":"70","author":"Chan","year":"2004","journal-title":"Biol. Reprod."},{"key":"2025030707341217800_r33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/dml045","article-title":"Uterine stem cells: what is the evidence?","volume":"13","author":"Gargett","year":"2007","journal-title":"Hum. Reprod. Update"},{"key":"2025030707341217800_r34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3727\/096368908784153922","article-title":"Multipotent menstrual blood stromal stem cells: isolation, characterization, and differentiation","volume":"17","author":"Patel","year":"2008","journal-title":"Cell Transplant."},{"key":"2025030707341217800_r35","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/IAI.70.6.2741-2751.2002","article-title":"Immunity to murine chlamydial genital infection","volume":"70","author":"Morrison","year":"2002","journal-title":"Infect. Immun."},{"key":"2025030707341217800_r36","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1053\/j.gastro.2010.06.060","article-title":"Polyamines impair immunity to Helicobacter pylori by inhibiting L-arginine uptake required for nitric oxide production","volume":"139","author":"Chaturvedi","year":"2010","journal-title":"Gastroenterology."},{"key":"2025030707341217800_r37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00726-011-1038-4","article-title":"Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis","volume":"42","author":"Chaturvedi","year":"2012","journal-title":"Amino Acids"},{"key":"2025030707341217800_r38","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.micinf.2008.06.008","article-title":"Arginase modulates Salmonella induced nitric oxide production in RAW264.7 macrophages and is required for Salmonella pathogenesis in mice model of infection","volume":"10","author":"Lahiri","year":"2008","journal-title":"Microbes Infect."},{"key":"2025030707341217800_r39","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.4049\/jimmunol.0902436","article-title":"Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages","volume":"184","author":"Lewis","year":"2010","journal-title":"J. Immunol."},{"key":"2025030707341217800_r40","doi-asserted-by":"crossref","first-page":"e17510","DOI":"10.1371\/journal.pone.0017510","article-title":"Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction","volume":"6","author":"Barry","year":"2011","journal-title":"PLoS ONE"},{"key":"2025030707341217800_r41","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1073\/pnas.90.9.3998","article-title":"Morphologic and antigenic characterization of interferon gamma-mediated persistent Chlamydia trachomatis infection in vitro","volume":"90","author":"Beatty","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707341217800_r42","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1002\/(SICI)1521-3773(19991102)38:21<3209::AID-ANIE3209>3.0.CO;2-6","article-title":"Fluorescent indicators for imaging nitric oxide production","volume":"38","author":"Kojima","year":"1999","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"2025030707341217800_r43","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1128\/IAI.70.6.3130-3142.2002","article-title":"Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities","volume":"70","author":"Alam","year":"2002","journal-title":"Infect. Immun."},{"key":"2025030707341217800_r44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.micpath.2003.08.005","article-title":"Differential expression of three Chlamydia trachomatis Hsp60-encoding genes in acute vs persistence infections","volume":"36","author":"G\u00e9rard","year":"2004","journal-title":"Microb. Pathog."},{"key":"2025030707341217800_r45","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1074\/jbc.C400498200","article-title":"Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation","volume":"280","author":"Bussi\u00e8re","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2025030707341217800_r46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1034\/j.1600-065X.2000.917307.x","article-title":"The role of nitric oxide in innate immunity","volume":"173","author":"Bogdan","year":"2000","journal-title":"Immunol. Rev."},{"key":"2025030707341217800_r47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/IAI.74.1.225-238.2006","article-title":"Comparison of gamma interferon-mediated antichlamydial defense mechanisms in human and mouse cells","volume":"74","author":"Roshick","year":"2006","journal-title":"Infect. Immun."},{"key":"2025030707341217800_r48","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1600-0897.2011.01064.x","article-title":"Expression of TLR 2, TLR 4 and iNOS in cervical monocytes of Chlamydia trachomatis-infected women and their role in host immune response","volume":"66","author":"Agrawal","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025030707341217800_r49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3360001","article-title":"Arginine metabolism: nitric oxide and beyond","volume":"336","author":"Wu","year":"1998","journal-title":"Biochem. J."},{"key":"2025030707341217800_r50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00178255","article-title":"On the evolution of arginases and related enzymes","volume":"39","author":"Ouzounis","year":"1994","journal-title":"J. Mol. Evol."},{"key":"2025030707341217800_r51","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1006\/bbrc.2000.2601","article-title":"Polyamines: mysterious modulators of cellular functions","volume":"271","author":"Igarashi","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030707341217800_r52","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1086\/529527","article-title":"Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages","volume":"197","author":"Cuervo","year":"2008","journal-title":"J. Infect. Dis."},{"key":"2025030707341217800_r53","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1128\/JB.01687-05","article-title":"Arginine homeostasis in J774.1 macrophages in the context of Mycobacterium bovis BCG infection","volume":"188","author":"Talaue","year":"2006","journal-title":"J. Bacteriol."},{"key":"2025030707341217800_r54","doi-asserted-by":"crossref","first-page":"e1000899","DOI":"10.1371\/journal.ppat.1000899","article-title":"Modulation of the arginase pathway in the context of microbial pathogenesis: a metabolic enzyme moonlighting as an immune modulator","volume":"6","author":"Das","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025030707341217800_r55","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1128\/IAI.01236-08","article-title":"Leishmania donovani ornithine decarboxylase is indispensable for parasite survival in the mammalian host","volume":"77","author":"Boitz","year":"2009","journal-title":"Infect. Immun."},{"key":"2025030707341217800_r56","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1128\/IAI.00073-11","article-title":"Spermidine synthase is required for virulence of Leishmania donovani","volume":"79","author":"Gilroy","year":"2011","journal-title":"Infect. Immun."},{"key":"2025030707341217800_r57","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.ijpara.2005.08.003","article-title":"Regulation of Toxoplasma gondii multiplication in BeWo trophoblast cells: cross-regulation of nitric oxide production and polyamine biosynthesis","volume":"35","author":"Pfaff","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"2025030707341217800_r58","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1096\/fj.04-3416fje","article-title":"Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo","volume":"19","author":"Kropf","year":"2005","journal-title":"FASEB J."},{"key":"2025030707341217800_r59","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1550-7408.1986.tb05654.x","article-title":"Effects of DL-alpha-difluoromethylornithine on Leishmania donovani promastigotes","volume":"33","author":"Kaur","year":"1986","journal-title":"J. Protozool."},{"key":"2025030707341217800_r60","first-page":"1157","article-title":"In vivo effect of eflornithine (DFMO) and some related compounds on Leishmania infantum preliminary communication","volume":"44","author":"Gradoni","year":"1989","journal-title":"Farmaco"},{"key":"2025030707341217800_r61","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1476-5381.1994.tb17058.x","article-title":"The mechanism of the inhibitory effect of polyamines on the induction of NOS: role of aldehyde metabolites","volume":"113","author":"Szabo","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"2025030707341217800_r62","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1073\/pnas.0735876100","article-title":"Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox","volume":"100","author":"Lee","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707341217800_r63","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.4049\/jimmunol.171.9.4561","article-title":"Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages","volume":"171","author":"El-Gayar","year":"2003","journal-title":"J. Immunol."},{"key":"2025030707341217800_r64","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1098419","article-title":"The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass","volume":"305","author":"H\u00f6gbom","year":"2004","journal-title":"Science"},{"key":"2025030707341217800_r65","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1128\/IAI.67.6.3175-3179.1999","article-title":"Lymphotoxin inhibits Chlamydia pneumoniae growth in HEp-2 cells","volume":"67","author":"Matsushima","year":"1999","journal-title":"Infect. Immun."},{"key":"2025030707341217800_r66","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1172\/JCI119782","article-title":"Inducible nitric oxide synthase: what difference does it make?","volume":"100","author":"Nathan","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2025030707341217800_r67","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00726-006-0425-8","article-title":"Protein tyrosine nitration in hydrophilic and hydrophobic environments","volume":"32","author":"Bartesaghi","year":"2007","journal-title":"Amino Acids"},{"key":"2025030707341217800_r68","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1365-2958.2007.05961.x","article-title":"The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions","volume":"66","author":"Genevaux","year":"2007","journal-title":"Mol. Microbiol."},{"key":"2025030707341217800_r69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399400002015","article-title":"Chaperonins are cell-signalling proteins: the unfolding biology of molecular chaperones","volume":"2","author":"Ranford","year":"2000","journal-title":"Expert Rev. Mol. Med."},{"key":"2025030707341217800_r70","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1128\/IAI.66.8.3666-3672.1998","article-title":"Characterization of the thermal stress response of Campylobacter jejuni","volume":"66","author":"Konkel","year":"1998","journal-title":"Infect. 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