{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:57:28Z","timestamp":1784966248827,"version":"3.55.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Systemic lupus erythematosus (SLE) is marked by a Th cell\u2013dependent B cell hyperresponsiveness, with frequent germinal center reactions and hypergammaglobulinemia. The specificity of Th cells in lupus remains unclear, but B cell Ids have been suggested. A hallmark is the presence of anti-dsDNA, mutated IgG autoantibodies with a preponderance of arginines in CDR3 of the Ig variable H chain (IgVH). B cells can present V region\u2013derived Id peptides on their MHC class II molecules to Id-specific Th cells. We show that Id-specific Th cells support the proliferation of anti-dsDNA Id+ B cells in mice suffering from systemic autoimmune disease with SLE-like features. Mice developed marked clonal expansions of B cells; half of the IgVH sequences were clonally related. Anti-dsDNA B cells made up 40% of B cells in end-stage disease. The B cells expressed mutated IgVH with multiple arginines in CDR3. Hence, Id-driven T cell\u2013B cell collaboration supported the production of classical anti-dsDNA Abs, recapitulating the characteristics of such Abs in SLE. The results support the concept that Id-specific Th cells may trigger the development of SLE and suggest that manipulation of the Id-specific T cell repertoire could play a role in treatment.<\/jats:p>","DOI":"10.4049\/jimmunol.1400640","type":"journal-article","created":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T01:37:02Z","timestamp":1408153022000},"page":"2691-2698","source":"Crossref","is-referenced-by-count":15,"title":["Idiotype-Specific Th Cells Support Oligoclonal Expansion of Anti-dsDNA B Cells in Mice with Lupus"],"prefix":"10.1093","volume":"193","author":[{"given":"Kristin","family":"Aas-Hanssen","sequence":"first","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane","family":"Funderud","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M","family":"Thompson","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarne","family":"Bogen","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo , 0424 Oslo ,","place":["Norway"]},{"name":"K.G. Jebsen Centre for Influenza Vaccine Research, Department of Immunology, Oslo University Hospital, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvig A","family":"Munthe","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation, Department of Immunology, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo , 0424 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"2025030707361109800_r1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/ni0901-764","article-title":"Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity","volume":"2","author":"Lipsky","year":"2001","journal-title":"Nat. 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