{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:12:59Z","timestamp":1770484379693,"version":"3.49.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Extracorporeal photopheresis (ECP) is a widely used clinical cell-based therapy exhibiting efficacy in heterogenous immune-mediated diseases such as cutaneous T cell lymphoma, graft-versus-host disease, and organ allograft rejection. Despite its documented efficacy in cancer immunotherapy, little is known regarding the induction of immunostimulatory mediators by ECP. In this article, we show that ECP promotes marked release of the prototypic immunostimulatory cytokine IL-1\u03b2. ECP primes IL-1\u03b2 production and activates IL-1\u03b2 maturation and release in the context of caspase-1 activation in monocytes and myeloid dendritic cells. Of interest, IL-1\u03b2 maturation by ECP was fully intact in murine cells deficient in caspase-1, suggesting the predominance of an inflammasome-independent pathway for ECP-dependent IL-1\u03b2 maturation. Clinically, patient analysis revealed significantly increased IL-1\u03b2 production in stimulated leukapheresis concentrates and peripheral blood samples after ECP. Collectively, these results provide evidence for promotion of IL-1\u03b2 production by ECP and offer new insight into the immunostimulatory capacity of ECP.<\/jats:p>","DOI":"10.4049\/jimmunol.1400694","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T03:27:12Z","timestamp":1423884432000},"page":"2569-2577","source":"Crossref","is-referenced-by-count":26,"title":["Extracorporeal Photopheresis Promotes IL-1\u03b2 Production"],"prefix":"10.1093","volume":"194","author":[{"given":"Erhan","family":"Yakut","sequence":"first","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig\u2013University Giessen , D-35390 Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Jakobs","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, University Hospital, University of Bonn , 53127 Bonn ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Peric","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig\u2013University Giessen , D-35390 Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Michel","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig\u2013University Giessen , D-35390 Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelli","family":"Baal","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig\u2013University Giessen , D-35390 Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Bein","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig\u2013University Giessen , D-35390 Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Br\u00fcne","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt , 60590 Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veit","family":"Hornung","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, University Hospital, University of Bonn , 53127 Bonn ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Hackstein","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig\u2013University Giessen , D-35390 Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,3,15]]},"reference":[{"key":"2025030705231509600_r1","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1182\/blood.V96.7.2426","article-title":"Extracorporeal photochemotherapy in the treatment of severe steroid-refractory acute graft-versus-host disease: a pilot study","volume":"96","author":"Greinix","year":"2000","journal-title":"Blood"},{"key":"2025030705231509600_r2","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1182\/blood-2008-03-141481","article-title":"A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease","volume":"112","author":"Flowers","year":"2008","journal-title":"Blood"},{"key":"2025030705231509600_r3","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1111\/j.1537-2995.2009.02289.x","article-title":"Mini buffy coat photopheresis for children and critically ill patients with extracorporeal photopheresis contraindications","volume":"49","author":"Hackstein","year":"2009","journal-title":"Transfusion"},{"key":"2025030705231509600_r4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/jca.20274","article-title":"Update on extracorporeal photopheresis in heart and lung transplantation","volume":"26","author":"Marques","year":"2011","journal-title":"J. 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