{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:45:47Z","timestamp":1775151947387,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239\u0394nef vaccination recruits plasma cells and induces ectopic lymphoid follicle formation beneath the mucosal epithelium in the rhesus macaque female reproductive tract. The plasma cells and ectopic follicles produce IgG Abs reactive with viral envelope glycoprotein gp41 trimers, and these Abs are concentrated on the path of virus entry by the neonatal FcR in cervical reserve epithelium and in vaginal epithelium. This local Ab production and delivery system correlated spatially and temporally with the maturation of local protection against high-dose pathogenic SIV vaginal challenge. Thus, designing vaccines to elicit production and concentration of Abs at mucosal frontlines could aid in the development of an effective vaccine to protect women against HIV-1.<\/jats:p>","DOI":"10.4049\/jimmunol.1400820","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T02:14:09Z","timestamp":1408414449000},"page":"3113-3125","source":"Crossref","is-referenced-by-count":59,"title":["Live Simian Immunodeficiency Virus Vaccine Correlate of Protection: Local Antibody Production and Concentration on the Path of Virus Entry"],"prefix":"10.1093","volume":"193","author":[{"given":"Qingsheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, and Center for HIV\/AIDS Vaccine Immunology and Immunogen Design, The Scripps Research Institute , La Jolla, CA 92037"},{"name":"Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA 02129"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Pambuccian","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Wietgrefe","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"Southern","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cavan S","family":"Reilly","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J","family":"Skinner","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota , St. Paul, MN 55108"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L","family":"Zupancic","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John V","family":"Carlis","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, College of Science and Engineering, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Michael","family":"Piatak","sequence":"additional","affiliation":[{"name":"AIDS and Cancer Virus Program, Science Applications International Corporation\u2013Frederick, Inc., National Cancer Institute , Frederick, MD 21702"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Waterman","sequence":"additional","affiliation":[{"name":"ZeptoMetrix Corporation , Buffalo, NY 14202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Keith","family":"Reeves","sequence":"additional","affiliation":[{"name":"New England Primate Research Center, Harvard Medical School , Southborough, MA 01772"},{"name":"Infectious Disease Unit, Department of Medicine, Massachusetts General Hospital , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Masek-Hammerman","sequence":"additional","affiliation":[{"name":"New England Primate Research Center, Harvard Medical School , Southborough, MA 01772"},{"name":"Infectious Disease Unit, Department of Medicine, Massachusetts General Hospital , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia A","family":"Derdeyn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine and Emory Vaccine Center, Emory University , Yerkes, Atlanta, GA 30329"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D","family":"Alpert","sequence":"additional","affiliation":[{"name":"New England Primate Research Center, Harvard Medical School , Southborough, MA 01772"},{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T","family":"Evans","sequence":"additional","affiliation":[{"name":"New England Primate Research Center, Harvard Medical School , Southborough, MA 01772"},{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Kohler","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Molecular Genetics, University of Kentucky , Lexington, KY 40536"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sybille","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"ImmPheron Inc. , Lexington, KY 40509"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center for Infectious Diseases, Tulane University , New Orleans, LA 70112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D","family":"Lifson","sequence":"additional","affiliation":[{"name":"AIDS and Cancer Virus Program, Science Applications International Corporation\u2013Frederick, Inc., National Cancer Institute , Frederick, MD 21702"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis R","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, and Center for HIV\/AIDS Vaccine Immunology and Immunogen Design, The Scripps Research Institute , La Jolla, CA 92037"},{"name":"Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA 02129"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Paul","family":"Johnson","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard , Charlestown, MA 02129"},{"name":"New England Primate Research Center, Harvard Medical School , Southborough, MA 01772"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley T","family":"Haase","sequence":"additional","affiliation":[{"name":"Department of 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