{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:33:37Z","timestamp":1783762417699,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Principles to guide design of an effective vaccine against HIV are greatly needed, particularly to protect women in the pandemic\u2019s epicenter in Africa. We have been seeking these principles by identifying correlates of the robust protection associated with SIVmac239\u0394nef vaccination in the SIV-rhesus macaque animal model of HIV-1 transmission to women. We identified one correlate of SIVmac239\u0394nef protection against vaginal challenge as a resident mucosal system for SIV-gp41 trimer Ab production and neonatal FcR-mediated concentration of these Abs on the path of virus entry to inhibit establishment of infected founder populations at the portal of entry. In this study, we identify blocking CD4+ T cell recruitment to thereby inhibit local expansion of infected founder populations as a second correlate of protection. Virus-specific immune complex interactions with the inhibitory Fc\u03b3RIIb receptor in the epithelium lining the cervix initiate expression of genes that block recruitment of target cells to fuel local expansion. Immune complex\u2013Fc\u03b3RIIb receptor interactions at mucosal frontlines to dampen the innate immune response to vaginal challenge could be a potentially general mechanism for the mucosal immune system to sense and modulate the response to a previously encountered pathogen. Designing vaccines to provide protection without eliciting these transmission-promoting innate responses could contribute to developing an effective HIV-1 vaccine.<\/jats:p>","DOI":"10.4049\/jimmunol.1400822","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T04:20:04Z","timestamp":1408594804000},"page":"3126-3133","source":"Crossref","is-referenced-by-count":33,"title":["Live Simian Immunodeficiency Virus Vaccine Correlate of Protection: Immune Complex\u2013Inhibitory Fc Receptor Interactions That Reduce Target Cell Availability"],"prefix":"10.1093","volume":"193","author":[{"given":"Anthony J","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W","family":"Wietgrefe","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cavan S","family":"Reilly","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Southern","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E","family":"Perkey","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Kohler","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Molecular Genetics, University of Kentucky , Lexington, KY 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybille","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"ImmPheron Inc. , Lexington, KY 40509"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center for Infectious Diseases, Tulane University , New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V","family":"Carlis","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, College of Science and Engineering, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Nebraska Center for Virology, School of Biological Sciences, University of Nebraska , Lincoln, NE 68583"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Paul","family":"Johnson","sequence":"additional","affiliation":[{"name":"New England Primate Research Center, Harvard Medical School, Southborough Campus , Southborough, MA 01772"},{"name":"Ragon Institute of MGH, MIT and Harvard , Charlestown, MA 02129"},{"name":"Infectious Disease Unit, Department of Medicine, Massachusetts General Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley T","family":"Haase","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Minnesota , Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"2025030707355193500_r1","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1371\/journal.pmed.0020298","article-title":"Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial","volume":"2","author":"Auvert","year":"2005","journal-title":"PLoS Med."},{"key":"2025030707355193500_r2","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1056\/NEJMoa1011205","article-title":"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men","volume":"363","author":"Grant","year":"2010","journal-title":"N. 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