{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:20:08Z","timestamp":1792218008251,"version":"4.4.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Immunodominance describes a phenomenon whereby the immune system consistently targets only a fraction of the available Ag pool derived from a given pathogen. In the case of CD8+ T cells, these constrained epitope-targeting patterns are linked to HLA class I expression and determine disease progression. Despite the biological importance of these predetermined response hierarchies, little is known about the factors that control immunodominance in vivo. In this study, we conducted an extensive analysis of CD8+ T cell responses restricted by a single HLA class I molecule to evaluate the mechanisms that contribute to epitope-targeting frequency and antiviral efficacy in HIV-1 infection. A clear immunodominance hierarchy was observed across 20 epitopes restricted by HLA-B*42:01, which is highly prevalent in populations of African origin. Moreover, in line with previous studies, Gag-specific responses and targeting breadth were associated with lower viral load set-points. However, peptide\u2013HLA-B*42:01 binding affinity and stability were not significantly linked with targeting frequencies. Instead, immunodominance correlated with epitope-specific usage of public TCRs, defined as amino acid residue\u2013identical TRB sequences that occur in multiple individuals. Collectively, these results provide important insights into a potential link between shared TCR recruitment, immunodominance, and antiviral efficacy in a major human infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1400854","type":"journal-article","created":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T03:26:36Z","timestamp":1429932396000},"page":"5329-5345","source":"Crossref","is-referenced-by-count":36,"title":["CD8+ TCR Bias and Immunodominance in HIV-1 Infection"],"prefix":"10.1093","volume":"194","author":[{"given":"Henrik N","family":"Kl\u00f8verpris","sequence":"first","affiliation":[{"name":"Department of Paediatrics, University of Oxford , Oxford OX1 3SY ,","place":["United Kingdom"]},{"name":"Department of International Health, Immunology, and Microbiology, University of Copenhagen , 2200-Copenhagen N ,","place":["Denmark"]},{"name":"KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal , Durban 4001 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"McGregor","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford , Oxford OX1 3SY ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E","family":"McLaren","sequence":"additional","affiliation":[{"name":"Institute of Infection and Immunity, Cardiff University School of Medicine , Cardiff CF14 4XN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Ladell","sequence":"additional","affiliation":[{"name":"Institute of Infection and Immunity, Cardiff University School of Medicine , Cardiff CF14 4XN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"Harndahl","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology, and Microbiology, University of Copenhagen , 2200-Copenhagen N ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Stryhn","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology, and Microbiology, University of Copenhagen , 2200-Copenhagen N ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Carlson","sequence":"additional","affiliation":[{"name":"Microsoft Research, eScience Group , Los Angeles, CA 90024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Koofhethile","sequence":"additional","affiliation":[{"name":"HIV Pathogenesis Program, Doris Duke Medical Research Institute, University of KwaZulu-Natal , Durban 4013 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Gerritsen","sequence":"additional","affiliation":[{"name":"Theoretical Biology Group, Utrecht University , 3584 CH Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Ke\u015fmir","sequence":"additional","affiliation":[{"name":"Theoretical Biology Group, Utrecht University , 3584 CH Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Sexual Health, Royal Berkshire Hospital , Reading RG1 5AN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Riddell","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medicine, Northamptonshire Healthcare National Health Service Trust, Northampton General Hospital , Cliftonville, Northampton NN1 5BD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graz","family":"Luzzi","sequence":"additional","affiliation":[{"name":"Department of Sexual Health, Wycombe Hospital , High Wycombe HP11 2TT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alasdair","family":"Leslie","sequence":"additional","affiliation":[{"name":"KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal , Durban 4001 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D","family":"Walker","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard , Boston, MA 02129"},{"name":"Howard Hughes Medical Institute , Chevy Chase, MD 20815"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thumbi","family":"Ndung\u2019u","sequence":"additional","affiliation":[{"name":"KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal , Durban 4001 ,","place":["South Africa"]},{"name":"HIV Pathogenesis Program, Doris Duke Medical Research Institute, University of KwaZulu-Natal , Durban 4013 ,","place":["South Africa"]},{"name":"Max Planck Institute for Infection Biology , D-10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8363-1999","authenticated-orcid":false,"given":"S\u00f8ren","family":"Buus","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology, and Microbiology, University of Copenhagen , 2200-Copenhagen N ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Price","sequence":"additional","affiliation":[{"name":"Institute of Infection and Immunity, Cardiff University School of Medicine , Cardiff CF14 4XN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Goulder","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford , Oxford OX1 3SY ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"2025030706325100100_r1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1126\/science.271.5246.173","article-title":"Immunology taught by viruses","volume":"271","author":"Zinkernagel","year":"1996","journal-title":"Science"},{"key":"2025030706325100100_r2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.immuni.2006.09.005","article-title":"Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses","volume":"25","author":"Yewdell","year":"2006","journal-title":"Immunity"},{"key":"2025030706325100100_r3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm.f.1774","article-title":"CD8+ T cell efficacy in vaccination and disease","volume":"14","author":"Appay","year":"2008","journal-title":"Nat. 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