{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:01:38Z","timestamp":1791151298832,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pemphigus vulgaris (PV) is considered as a model for an autoantibody-mediated organ-specific autoimmune disorder. IgG autoantibodies directed against the desmosomal cadherin desmoglein 3 (Dsg3), the major autoantigen in PV, cause loss of epidermal keratinocyte adhesion, resulting in blisters and erosions of the skin and mucous membranes. The association of human autoimmune diseases with distinct HLA alleles is a well-known phenomenon, such as the association with HLA-DRB1*04:02 in PV. However, direct evidence that HLA-DRB1*04:02\u2013restricted autoreactive CD4+ T cells recognizing immunodominant epitopes of Dsg3 initiate the production of Dsg3-reactive IgG autoantibodies is still missing. In this study, we show in a humanized HLA-DRB1*04:02\u2013transgenic mouse model that HLA-DRB1*04:02\u2013restricted T cell recognition of human Dsg3 epitopes leads to the induction of pathogenic IgG Abs that induce loss of epidermal adhesion, a hallmark in the immune pathogenesis of PV. Activation of Dsg3-reactive CD4+ T cells by distinct human Dsg3 peptides that bind to HLA-DR\u03b21*04:02 is tightly regulated by the HLA-DRB1*04:02 allele and leads, via CD40-CD40L\u2013dependent T cell\u2013B cell interaction, to the production of IgG Abs that recognize both N- and COOH-terminal epitopes of the human Dsg3 ectodomain. These findings demonstrate key cellular and humoral immune events in the autoimmune cascade of PV in a humanized HLA-transgenic mouse model. We show that CD4+ T cells recognizing immunodominant Dsg3 epitopes in the context of the PV-associated HLA-DRB1*04:02 induce the secretion of Dsg3-specific IgG in vivo. Finally, these results identify Dsg3-reactive CD4+ T cells as potential therapeutic targets in the future.<\/jats:p>","DOI":"10.4049\/jimmunol.1401081","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T05:44:34Z","timestamp":1411623874000},"page":"4391-4399","source":"Crossref","is-referenced-by-count":70,"title":["Pathogenic IgG Antibodies against Desmoglein 3 in Pemphigus Vulgaris Are Regulated by HLA-DRB1*04:02\u2013Restricted T Cells"],"prefix":"10.1093","volume":"193","author":[{"given":"R\u00fcdiger","family":"Eming","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology, Philipps University , D-35043 Marburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Hennerici","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Philipps University , D-35043 Marburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"B\u00e4cklund","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet , S-171 77 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Feliciani","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical and Experimental Medicine, University of Parma , 43100 Parma ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C","family":"Visconti","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Stanford University , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Willenborg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Philipps University , D-35043 Marburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Wohde","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Philipps University , D-35043 Marburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikard","family":"Holmdahl","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet , S-171 77 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grete","family":"S\u00f8nderstrup","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Stanford University , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Philipps University , D-35043 Marburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"2025030707433193000_r1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(05)66829-8","article-title":"Pemphigus","volume":"366","author":"Bystryn","year":"2005","journal-title":"Lancet"},{"key":"2025030707433193000_r2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/jid.2011.390","article-title":"Desmoglein as a target in skin disease and beyond","volume":"132","author":"Amagai","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"2025030707433193000_r3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(91)90360-B","article-title":"Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion","volume":"67","author":"Amagai","year":"1991","journal-title":"Cell"},{"key":"2025030707433193000_r4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.humimm.2005.09.003","article-title":"Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris","volume":"67","author":"Lee","year":"2006","journal-title":"Hum. Immunol."},{"key":"2025030707433193000_r5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/08916930600971497","article-title":"Immunogenetics of pemphigus: an update","volume":"39","author":"Tron","year":"2006","journal-title":"Autoimmunity"},{"key":"2025030707433193000_r6","doi-asserted-by":"crossref","first-page":"11935","DOI":"10.1073\/pnas.92.25.11935","article-title":"Structural basis for major histocompatibility complex (MHC)\u2011linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris","volume":"92","author":"Wucherpfennig","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707433193000_r7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1172\/JCI119130","article-title":"Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris","volume":"99","author":"Lin","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2025030707433193000_r8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1523-1747.1998.00086.x","article-title":"Recognition of desmoglein 3 by autoreactive T cells in pemphigus vulgaris patients and normals","volume":"110","author":"Hertl","year":"1998","journal-title":"J. Invest. Dermatol."},{"key":"2025030707433193000_r9","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.4049\/jimmunol.172.6.3883","article-title":"T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals","volume":"172","author":"Veldman","year":"2004","journal-title":"J. Immunol."},{"key":"2025030707433193000_r10","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1084\/jem.181.5.1597","article-title":"Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases","volume":"181","author":"Wucherpfennig","year":"1995","journal-title":"J. Exp. Med."},{"key":"2025030707433193000_r11","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1073\/pnas.95.7.3833","article-title":"T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin","volume":"95","author":"Congia","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707433193000_r12","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/1529-0131(199907)42:7<1497::AID-ANR25>3.0.CO;2-#","article-title":"T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles","volume":"42","author":"Cope","year":"1999","journal-title":"Arthritis Rheum."},{"key":"2025030707433193000_r13","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/j.1460-2075.1993.tb05798.x","article-title":"Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4","volume":"12","author":"Killeen","year":"1993","journal-title":"EMBO J."},{"key":"2025030707433193000_r14","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0092-8674(91)90448-8","article-title":"Mice lacking MHC class II molecules","volume":"66","author":"Cosgrove","year":"1991","journal-title":"Cell"},{"key":"2025030707433193000_r15","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1073\/pnas.132254199","article-title":"Predominant selection of T cells specific for the glycosylated collagen type II epitope (263\u2011270) in humanized transgenic mice and in rheumatoid arthritis","volume":"99","author":"B\u00e4cklund","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707433193000_r16","doi-asserted-by":"crossref","first-page":"12646","DOI":"10.1073\/pnas.0403831101","article-title":"Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene","volume":"101","author":"Hultqvist","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707433193000_r17","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/art.27460","article-title":"Breaking T cell tolerance against self type II collagen in HLA-DR4\u2011transgenic mice and development of autoimmune arthritis","volume":"62","author":"Batsalova","year":"2010","journal-title":"Arthritis Rheum."},{"key":"2025030707433193000_r18","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.4049\/jimmunol.159.4.2010","article-title":"Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins","volume":"159","author":"Ishii","year":"1997","journal-title":"J. Immunol."},{"key":"2025030707433193000_r19","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4049\/jimmunol.170.1.635","article-title":"Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles","volume":"170","author":"Veldman","year":"2003","journal-title":"J. Immunol."},{"key":"2025030707433193000_r20","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1600-0625.2006.00451.x","article-title":"IgG reactivity against non-conformational NH-terminal epitopes of the desmoglein 3 ectodomain relates to clinical activity and phenotype of pemphigus vulgaris","volume":"15","author":"M\u00fcller","year":"2006","journal-title":"Exp. Dermatol."},{"key":"2025030707433193000_r21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"2025030707433193000_r22","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/nprot.2007.296","article-title":"Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester","volume":"2","author":"Quah","year":"2007","journal-title":"Nat. Protoc."},{"key":"2025030707433193000_r23","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.0022-202X.2005.23714.x","article-title":"In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris","volume":"124","author":"Ishii","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"2025030707433193000_r24","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.ajpath.2010.10.016","article-title":"IgG autoantibodies against desmocollin 3 in pemphigus sera induce loss of keratinocyte adhesion","volume":"178","author":"Rafei","year":"2011","journal-title":"Am. J. Pathol."},{"key":"2025030707433193000_r25","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.4049\/jimmunol.167.9.5439","article-title":"Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins","volume":"167","author":"Sekiguchi","year":"2001","journal-title":"J. Immunol."},{"key":"2025030707433193000_r26","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1038\/jid.2008.172","article-title":"Rituximab exerts a dual effect in pemphigus vulgaris","volume":"128","author":"Eming","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"2025030707433193000_r27","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1073\/pnas.88.11.5056","article-title":"Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris","volume":"88","author":"Ahmed","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707433193000_r28","doi-asserted-by":"crossref","first-page":"7658","DOI":"10.1073\/pnas.87.19.7658","article-title":"Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris","volume":"87","author":"Ahmed","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707433193000_r29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-7580-2-1","article-title":"Modeling the bound conformation of Pemphigus vulgaris\u2011associated peptides to MHC class II DR and DQ alleles","volume":"2","author":"Tong","year":"2006","journal-title":"Immunome Res."},{"key":"2025030707433193000_r30","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1523-1747.1998.00156.x","article-title":"Heterogeneous MHC II restriction pattern of autoreactive desmoglein 3 specific T cell responses in pemphigus vulgaris patients and normals","volume":"110","author":"Hertl","year":"1998","journal-title":"J. Invest. Dermatol."},{"key":"2025030707433193000_r31","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1172\/JCI3335","article-title":"Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls","volume":"102","author":"B\u00fcdinger","year":"1998","journal-title":"J. Clin. Invest."},{"key":"2025030707433193000_r32","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.0906-6705.2005.00329.x","article-title":"Ex vivo analysis of desmoglein 1-responsive T-helper (Th) 1 and Th2 cells in patients with pemphigus foliaceus and healthy individuals","volume":"14","author":"Gebhard","year":"2005","journal-title":"Exp. Dermatol."},{"key":"2025030707433193000_r33","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/clim.2002.5259","article-title":"Isotypes and antigenic profiles of pemphigus foliaceus and pemphigus vulgaris autoantibodies","volume":"105","author":"Hacker","year":"2002","journal-title":"Clin. Immunol."},{"key":"2025030707433193000_r34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2230.2005.01836.x","article-title":"Direct characterization of human T cells in pemphigus vulgaris reveals elevated autoantigen-specific Th2 activity in association with active disease","volume":"30","author":"Rizzo","year":"2005","journal-title":"Clin. Exp. Dermatol."},{"key":"2025030707433193000_r35","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/08820130902943097","article-title":"Involvement of T(H)1\/T(H)2 cytokines in the pathogenesis of autoimmune skin disease-Pemphigus vulgaris","volume":"38","author":"Satyam","year":"2009","journal-title":"Immunol. Invest."},{"key":"2025030707433193000_r36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.clim.2009.11.006","article-title":"Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3","volume":"134","author":"Nagel","year":"2010","journal-title":"Clin. Immunol."},{"key":"2025030707433193000_r37","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/exd.12229","article-title":"Autoreactive T cells in the immune pathogenesis of pemphigus vulgaris","volume":"22","author":"Amber","year":"2013","journal-title":"Exp. Dermatol."},{"key":"2025030707433193000_r38","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.4049\/jimmunol.172.10.6468","article-title":"Type I regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris","volume":"172","author":"Veldman","year":"2004","journal-title":"J. Immunol."},{"key":"2025030707433193000_r39","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1172\/JCI28547","article-title":"T cell control in autoimmune bullous skin disorders","volume":"116","author":"Hertl","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2025030707433193000_r40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1034\/j.1600-0625.2000.009004229.x","article-title":"Cloning of the mouse desmoglein 3 gene (Dsg3): interspecies conservation within the cadherin superfamily","volume":"9","author":"Ishikawa","year":"2000","journal-title":"Exp. Dermatol."},{"key":"2025030707433193000_r41","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1073\/pnas.91.13.6151","article-title":"Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region \u03b2-chain T-cell repertoire and mediates an HLA-DR\u2011restricted immune response","volume":"91","author":"Fugger","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030707433193000_r42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3109\/08916939908993852","article-title":"HLA class II restriction of autoreactive T cell responses in pemphigus vulgaris: review of the literature and potential applications for the development of a specific immunotherapy","volume":"30","author":"Riechers","year":"1999","journal-title":"Autoimmunity"},{"key":"2025030707433193000_r43","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1002\/art.11181","article-title":"Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis","volume":"48","author":"Cambridge","year":"2003","journal-title":"Arthritis Rheum."},{"key":"2025030707433193000_r44","doi-asserted-by":"crossref","first-page":"175ra130","DOI":"10.1126\/scitranslmed.3005166","article-title":"Long-term remissions of severe pemphigus after rituximab therapy are associated with prolonged failure of desmoglein B cell response","volume":"5","author":"Colliou","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"2025030707433193000_r45","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1046\/j.1523-1747.2000.00840.x","article-title":"Detection of antigen-specific B cells in patients with pemphigus vulgaris by enzyme-linked immunospot assay: requirement of T cell collaboration for autoantibody production","volume":"114","author":"Nishifuji","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"2025030707433193000_r46","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/1521-4141(200203)32:3<627::AID-IMMU627>3.0.CO;2-1","article-title":"Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris","volume":"32","author":"Tsunoda","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"2025030707433193000_r47","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI8748","article-title":"Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus","volume":"105","author":"Amagai","year":"2000","journal-title":"J. Clin. Invest."},{"key":"2025030707433193000_r48","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.4049\/jimmunol.182.3.1740","article-title":"A single helper T cell clone is sufficient to commit polyclonal naive B cells to produce pathogenic IgG in experimental pemphigus vulgaris","volume":"182","author":"Takahashi","year":"2009","journal-title":"J. Immunol."},{"key":"2025030707433193000_r49","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s10875-011-9597-4","article-title":"Cognate Th2-B cell interaction is essential for the autoantibody production in pemphigus vulgaris","volume":"32","author":"Zhu","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"2025030707433193000_r50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.clim.2012.08.004","article-title":"Epitope-specific immune tolerization ameliorates experimental autoimmune encephalomyelitis","volume":"145","author":"Billetta","year":"2012","journal-title":"Clin. Immunol."},{"key":"2025030707433193000_r51","doi-asserted-by":"crossref","first-page":"188ra175","DOI":"10.1126\/scitranslmed.3006168","article-title":"Antigen-specific tolerance by autologous myelin peptide-coupled cells: a phase 1 trial in multiple sclerosis","volume":"5","author":"Lutterotti","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"2025030707433193000_r52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0625.2007.00615.x","article-title":"IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris","volume":"17","author":"M\u00fcller","year":"2008","journal-title":"Exp. Dermatol."},{"key":"2025030707433193000_r53","doi-asserted-by":"crossref","first-page":"321950","DOI":"10.1155\/2010\/321950","article-title":"Targeted immunotherapy with rituximab leads to a transient alteration of the IgG autoantibody profile in pemphigus vulgaris","volume":"2010","author":"M\u00fcller","year":"2010","journal-title":"Dermatol. Res. Pract."},{"key":"2025030707433193000_r54","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1038\/jid.2012.1","article-title":"Differential IgG recognition of desmoglein 3 by paraneoplastic pemphigus and pemphigus vulgaris sera","volume":"132","author":"Brandt","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"2025030707433193000_r55","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jdermsci.2004.03.011","article-title":"Conformational epitope mapping of antibodies against desmoglein 3 in experimental murine pemphigus vulgaris","volume":"35","author":"Anzai","year":"2004","journal-title":"J. Dermatol. Sci."},{"key":"2025030707433193000_r56","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.clim.2009.12.010","article-title":"T and B cells target identical regions of the non-collagenous domain 1 of type VII collagen in epidermolysis bullosa acquisita","volume":"135","author":"M\u00fcller","year":"2010","journal-title":"Clin. Immunol."},{"key":"2025030707433193000_r57","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1684\/ejd.2012.1709","article-title":"Dystrophic epidermolysis bullosa pruriginosa with autoantibodies against collagen VII","volume":"22","author":"Jedlickova","year":"2012","journal-title":"Eur. J. Dermatol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/193\/9\/4391\/62226861\/1401081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/193\/9\/4391\/62226861\/1401081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T08:14:26Z","timestamp":1741335266000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/193\/9\/4391\/7966568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,1]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,11,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1401081","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,11]]},"published":{"date-parts":[[2014,11,1]]}}}