{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T05:15:17Z","timestamp":1741410917570,"version":"3.38.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Peritoneal B1a cells expressing CD5 and CD11b generate autoantibody-producing precursors in autoimmune-prone mice. Previous studies show reduced JNK signaling in peritoneal B1a cells of female New Zealand Black mice and an abnormal increase of protein phosphatase 2A subunit G5PR that regulates BCR-mediated JNK signaling as a cause of autoimmunity. To investigate the mechanism regulating B1a differentiation into autoantibody-secreting plasmablasts (PBs), we applied an in vitro culture system that supports long-term growth of germinal center (GC) B cells (iGB) with IL-4, CD40L, and BAFF. Compared with spleen B2 cells, B1a cells differentiated into GC-like B cells, but more markedly into PBs, and underwent class switching toward IgG1. During iGB culture, B1a cells expressed GC-associated aicda, g5pr, and bcl6, and markedly PB-associated prdm1, irf4, and xbp1. B1a-derived iGB cells from New Zealand Black \u00d7 New Zealand White F1 mice highly differentiated into autoantibody-secreting PBs in vitro and localized to the GC area in vivo. In iGB culture, JNK inhibitor SP600125 augmented the differentiation of C57BL\/6 B1a cells into PBs. Furthermore, B1a cells from G5PR transgenic mice markedly differentiated into IgM and IgG autoantibody\u2013secreting PBs. In conclusion, JNK regulation is critical to suppress autoantibody-secreting PBs from peritoneal B1a cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1401127","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T05:11:30Z","timestamp":1421730690000},"page":"1480-1488","source":"Crossref","is-referenced-by-count":6,"title":["JNK Regulatory Molecule G5PR Induces IgG Autoantibody\u2013Producing Plasmablasts from Peritoneal B1a Cells"],"prefix":"10.1093","volume":"194","author":[{"given":"Masahiro","family":"Kitabatake","sequence":"first","affiliation":[{"name":"Department of Immunology, Graduate School of Medical Sciences, Kumamoto University , Kumamoto 860-8556 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medical Sciences, Kumamoto University , Kumamoto 860-8556 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medical Sciences, Kumamoto University , Kumamoto 860-8556 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medical Sciences, Kumamoto University , Kumamoto 860-8556 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medical Sciences, Kumamoto University , Kumamoto 860-8556 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Nojima","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medical Sciences, Kumamoto University , Kumamoto 860-8556 ,","place":["Japan"]},{"name":"Tokyo Metropolitan Institute of Medical Science , Tokyo 156-8506 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,2,15]]},"reference":[{"key":"2025030705022424700_r1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJM197701202960301","article-title":"Myasthenia gravis. 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