{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:48:50Z","timestamp":1791139730703,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Superantigens are immune-stimulatory toxins produced by Staphylococcus aureus, which are able to interact with host immune receptors to induce a massive release of cytokines, causing toxic shock syndrome and possibly death. In this article, we present the x-ray structure of staphylococcal enterotoxin B (SEB) in complex with its receptors, the TCR and MHC class II, forming a ternary complex. The structure, in combination with functional analyses, clearly shows how SEB adopts a wedge-like position when binding to the \u03b2-chain of TCR, allowing for an interaction between the \u03b1-chain of TCR and MHC. Furthermore, the binding mode also circumvents contact between TCR and the peptide presented by MHC, which enables SEB to initiate a peptide-independent activation of T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1401268","type":"journal-article","created":{"date-parts":[[2014,7,12]],"date-time":"2014-07-12T03:00:11Z","timestamp":1405134011000},"page":"1998-2004","source":"Crossref","is-referenced-by-count":58,"title":["Structure of the Superantigen Staphylococcal Enterotoxin B in Complex with TCR and Peptide\u2013MHC Demonstrates Absence of TCR\u2013Peptide Contacts"],"prefix":"10.1093","volume":"193","author":[{"given":"Karin E J","family":"R\u00f6dstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Experimental Medical Science, Lund University , 221 84 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Elbing","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Lund University , 221 84 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Lindkvist-Petersson","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Lund University , 221 84 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"2025030707302177000_r1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0092-8674(89)90980-X","article-title":"The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice","volume":"56","author":"White","year":"1989","journal-title":"Cell"},{"key":"2025030707302177000_r2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/207663a0","article-title":"Fractions of staphylococcal enterotoxin B","volume":"207","author":"Joseph","year":"1965","journal-title":"Nature"},{"key":"2025030707302177000_r3","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1084\/jem.167.5.1697","article-title":"T cell stimulation by staphylococcal enterotoxins. 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