{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:31:31Z","timestamp":1758990691653,"version":"3.38.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The type I IFN (IFN-\u03b1) response is crucial for viral clearance during primary viral infections. Plasmacytoid dendritic cells (pDCs) are important early responders during systemic viral infections and, in some cases, are the sole producers of IFN-\u03b1. However, their role in IFN-\u03b1 production during memory responses is unclear. We found that IFN-\u03b1 production is absent during a murine viral memory response, despite colocalization of virus and pDCs to the splenic marginal zone. The absence of IFN was dependent on circulating Ab and was reversed by the transgenic expression of the activating human Fc\u03b3RIIA receptor on pDCs. Furthermore, Fc\u03b3RIIB was required for Sendai virus immune complex uptake by splenic pDCs in vitro, and internalization via Fc\u03b3RIIb prevented cargo from accessing TLR signaling endosomes. Thus, pDCs bind viral immune complexes via Fc\u03b3RIIB and prevent IFN-\u03b1 production in vivo during viral memory responses. This Ab-dependent IFN-\u03b1 regulation may be an important mechanism by which the potentially deleterious effects of IFN-\u03b1 are prevented during a secondary infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1401296","type":"journal-article","created":{"date-parts":[[2015,3,28]],"date-time":"2015-03-28T14:45:39Z","timestamp":1427553939000},"page":"4240-4250","source":"Crossref","is-referenced-by-count":11,"title":["Fc\u03b3RIIB Prevents Inflammatory Type I IFN Production from Plasmacytoid Dendritic Cells during a Viral Memory Response"],"prefix":"10.1093","volume":"194","author":[{"given":"Marcella","family":"Flores","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Medicine, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Dermatology, Columbia University Medical Center , New York, NY 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Medicine, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Dermatology, Columbia University Medical Center , New York, NY 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Tyan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Medicine, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Dermatology, Columbia University Medical Center , New York, NY 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu Qing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Medicine, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Dermatology, Columbia University Medical Center , New York, NY 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliasger","family":"Salem","sequence":"additional","affiliation":[{"name":"Division of Pharmaceuticals, College of Pharmacy, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Clynes","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Medicine, Columbia University Medical Center , New York, NY 10032"},{"name":"Department of Dermatology, Columbia University Medical Center , New York, NY 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"key":"2025030706142460900_r1","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1084\/jem.20092695","article-title":"Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response","volume":"207","author":"Swanson","year":"2010","journal-title":"J. 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