{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:35:21Z","timestamp":1791423321271,"version":"4.3.3"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Inflammatory diseases such as Aicardi\u2013Gouti\u00e8res syndrome and severe systemic lupus erythematosus are generally lethal disorders that have been traced to defects in the exonuclease TREX1 (DNase III). Mice lacking TREX1 similarly die at an early age through comparable symptoms, including inflammatory myocarditis, through chronic activation of the stimulator of IFN genes (STING) pathway. In this study, we demonstrate that phagocytes rather than myocytes are predominantly responsible for causing inflammation, an outcome that could be alleviated following adoptive transfer of normal bone marrow into TREX1\u2212\/\u2212 mice. TREX1\u2212\/\u2212 macrophages did not exhibit significant augmented ability to produce proinflammatory cytokines compared with normal macrophages following exposure to STING-dependent activators, but rather appeared chronically stimulated by genomic DNA. These results shed molecular insight into inflammation and provide concepts for the design of new therapies.<\/jats:p>","DOI":"10.4049\/jimmunol.1401337","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T03:29:33Z","timestamp":1411788573000},"page":"4634-4642","source":"Crossref","is-referenced-by-count":182,"title":["Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING"],"prefix":"10.1093","volume":"193","author":[{"given":"Jeonghyun","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Cell Biology, University of Miami Miller School of Medicine , Miami, FL 33136"},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL 33136"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Miami Miller School of Medicine , Miami, FL 33136"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen N","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Miami Miller School of Medicine , Miami, FL 33136"},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL 33136"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"2025030707435062800_r1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N. 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