{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:00:48Z","timestamp":1791284448050,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High-throughput sequencing allows detailed study of the BCR repertoire postimmunization, but it remains unclear to what extent the de novo identification of Ag-specific sequences from the total BCR repertoire is possible. A conjugate vaccine containing Haemophilus influenzae type b (Hib) and group C meningococcal polysaccharides, as well as tetanus toxoid (TT), was used to investigate the BCR repertoire of adult humans following immunization and to test the hypothesis that public or convergent repertoire analysis could identify Ag-specific sequences. A number of Ag-specific BCR sequences have been reported for Hib and TT, which made a vaccine containing these two Ags an ideal immunological stimulus. Analysis of identical CDR3 amino acid sequences that were shared by individuals in the postvaccine repertoire identified a number of known Hib-specific sequences but only one previously described TT sequence. The extension of this analysis to nonidentical, but highly similar, CDR3 amino acid sequences revealed a number of other TT-related sequences. The anti-Hib avidity index postvaccination strongly correlated with the relative frequency of Hib-specific sequences, indicating that the postvaccination public BCR repertoire may be related to more conventional measures of immunogenicity correlating with disease protection. Analysis of public BCR repertoire provided evidence of convergent BCR evolution in individuals exposed to the same Ags. If this finding is confirmed, the public repertoire could be used for rapid and direct identification of protective Ag-specific BCR sequences from peripheral blood.<\/jats:p>","DOI":"10.4049\/jimmunol.1401405","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T04:24:01Z","timestamp":1415852641000},"page":"252-261","source":"Crossref","is-referenced-by-count":127,"title":["Identification of Antigen-Specific B Cell Receptor Sequences Using Public Repertoire Analysis"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-7381","authenticated-orcid":false,"given":"Johannes","family":"Tr\u00fcck","sequence":"first","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health Research Oxford Biomedical Research Centre , Oxford OX3 7LE ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maheshi N","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health Research Oxford Biomedical Research Centre , Oxford OX3 7LE ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob D","family":"Galson","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health Research Oxford Biomedical Research Centre , Oxford OX3 7LE ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Rance","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute , Cambridge CB10 1SA ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Parkhill","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute , Cambridge CB10 1SA ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerton","family":"Lunter","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics , Oxford OX3 7BN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Pollard","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health Research Oxford Biomedical Research Centre , Oxford OX3 7LE ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic F","family":"Kelly","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health Research Oxford Biomedical Research Centre , Oxford OX3 7LE ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2025031310012099500_r1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/302575a0","article-title":"Somatic generation of antibody diversity","volume":"302","author":"Tonegawa","year":"1983","journal-title":"Nature"},{"key":"2025031310012099500_r2","doi-asserted-by":"crossref","first-page":"20216","DOI":"10.1073\/pnas.0909775106","article-title":"Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire","volume":"106","author":"Glanville","year":"2009","journal-title":"Proc. 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Retrovirol."},{"key":"2025031310012099500_r18","doi-asserted-by":"crossref","first-page":"11651","DOI":"10.1128\/JVI.01762-08","article-title":"Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C","volume":"82","author":"Binley","year":"2008","journal-title":"J. Virol."},{"key":"2025031310012099500_r19","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.4049\/jimmunol.180.5.3279","article-title":"Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones","volume":"180","author":"Tian","year":"2008","journal-title":"J. Immunol."},{"key":"2025031310012099500_r20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00251-002-0453-9","article-title":"The human anti-thyroid peroxidase autoantibody repertoire in Graves\u2019 and Hashimoto\u2019s autoimmune thyroid diseases","volume":"54","author":"Chard\u00e8s","year":"2002","journal-title":"Immunogenetics"},{"key":"2025031310012099500_r21","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.chom.2013.05.008","article-title":"Convergent antibody signatures in human dengue","volume":"13","author":"Parameswaran","year":"2013","journal-title":"Cell Host Microbe"},{"key":"2025031310012099500_r22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chom.2014.05.013","article-title":"Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements","volume":"16","author":"Jackson","year":"2014","journal-title":"Cell Host Microbe"},{"key":"2025031310012099500_r23","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.4049\/jimmunol.135.4.2810","article-title":"Isoelectric focusing of human antibody to the Haemophilus influenzae b capsular polysaccharide: restricted and identical spectrotypes in adults","volume":"135","author":"Insel","year":"1985","journal-title":"J. Immunol."},{"key":"2025031310012099500_r24","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1172\/JCI116514","article-title":"Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens","volume":"91","author":"Adderson","year":"1993","journal-title":"J. Clin. Invest."},{"key":"2025031310012099500_r25","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1172\/JCI115394","article-title":"Variable region diversity in human circulating antibodies specific for the capsular polysaccharide of Haemophilus influenzae type b. Preferential usage of two types of VH3 heavy chains","volume":"88","author":"Silverman","year":"1991","journal-title":"J. Clin. Invest."},{"key":"2025031310012099500_r26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1521-6616(03)00094-9","article-title":"Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide: expression of canonical variable regions and their variants in vaccinated infants","volume":"108","author":"Lucas","year":"2003","journal-title":"Clin. Immunol."},{"key":"2025031310012099500_r27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-065X.1999.tb01343.x","article-title":"Polysaccharide vaccines as probes of antibody repertoires in man","volume":"171","author":"Lucas","year":"1999","journal-title":"Immunol. 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Dis."},{"key":"2025031310012099500_r31","first-page":"1029","article-title":"Avidity determinations for Haemophilus influenzae Type b anti-polyribosylribitol phosphate antibodies","volume":"12","author":"Romero-Steiner","year":"2005","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"2025031310012099500_r32","doi-asserted-by":"crossref","first-page":"W503","DOI":"10.1093\/nar\/gkn316","article-title":"IMGT\/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis","volume":"36","author":"Brochet","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2025031310012099500_r33","volume-title":"R Foundation for Statistical Computing","author":"R Core Team","year":"2013"},{"key":"2025031310012099500_r34","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-98141-3","volume-title":"ggplot2: Elegant graphics for data analysis","author":"Wickham","year":"2009"},{"key":"2025031310012099500_r35","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.4049\/jimmunol.147.5.1667","article-title":"Restricted Ig H chain V gene usage in the human antibody response to Haemophilus influenzae type b capsular polysaccharide","volume":"147","author":"Adderson","year":"1991","journal-title":"J. Immunol."},{"key":"2025031310012099500_r36","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.4049\/jimmunol.1000928","article-title":"Limits for antibody affinity maturation and repertoire diversification in hypervaccinated humans","volume":"187","author":"Poulsen","year":"2011","journal-title":"J. Immunol."},{"key":"2025031310012099500_r37","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.4049\/jimmunol.1000911","article-title":"Secondary immunization generates clonally related antigen-specific plasma cells and memory B cells","volume":"185","author":"Fr\u00f6lich","year":"2010","journal-title":"J. Immunol."},{"key":"2025031310012099500_r38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nbt.2492","article-title":"High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire","volume":"31","author":"DeKosky","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"2025031310012099500_r39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1380-2933(97)10003-3","article-title":"Three-dimensional structure of a human Fab with high affinity for tetanus toxoid","volume":"3","author":"Faber","year":"1998","journal-title":"Immunotechnology"},{"key":"2025031310012099500_r40","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1073\/pnas.1118979109","article-title":"Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells","volume":"109","author":"Li","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025031310012099500_r41","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.4049\/jimmunol.1101823","article-title":"Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence","volume":"187","author":"Krause","year":"2011","journal-title":"J. Immunol."},{"key":"2025031310012099500_r42","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0161-5890(96)00012-0","article-title":"Molecular characterization of a monoclonal antibody produced in response to a group C meningococcal polysaccharide peptide mimic","volume":"33","author":"Hutchins","year":"1996","journal-title":"Mol. Immunol."},{"key":"2025031310012099500_r43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0161-5890(99)00024-3","article-title":"Molecular analysis of the heavy chain of antibodies that recognize the capsular polysaccharide of Neisseria meningitidis in hu-PBMC reconstituted SCID mice and in the immunized human donor","volume":"36","author":"Smithson","year":"1999","journal-title":"Mol. Immunol."},{"key":"2025031310012099500_r44","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1101\/gr.111120.110","article-title":"Stampy: a statistical algorithm for sensitive and fast mapping of Illumina sequence reads","volume":"21","author":"Lunter","year":"2011","journal-title":"Genome Res."},{"key":"2025031310012099500_r45","doi-asserted-by":"crossref","first-page":"D753","DOI":"10.1093\/nar\/gkm987","article-title":"The vertebrate genome annotation (Vega) database","volume":"36","author":"Wilming","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2025031310012099500_r46","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1474-9726.2011.00732.x","article-title":"Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages","volume":"10","author":"Ademokun","year":"2011","journal-title":"Aging Cell"},{"key":"2025031310012099500_r47","doi-asserted-by":"crossref","first-page":"171ra19","DOI":"10.1126\/scitranslmed.3004794","article-title":"Lineage structure of the human antibody repertoire in response to influenza vaccination","volume":"5","author":"Jiang","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"2025031310012099500_r48","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fmicb.2012.00315","article-title":"Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics","volume":"3","author":"Zhu","year":"2012","journal-title":"Front. Microbiol."},{"key":"2025031310012099500_r49","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1126\/science.1207532","article-title":"Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing","volume":"333","author":"Wu","year":"2011","journal-title":"Science"},{"key":"2025031310012099500_r50","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.4049\/jimmunol.171.9.4680","article-title":"Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires","volume":"171","author":"Weitkamp","year":"2003","journal-title":"J. Immunol."},{"key":"2025031310012099500_r51","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.4049\/jimmunol.0803254","article-title":"Molecular dissection of antibody responses against pneumococcal surface protein A: evidence for diverse DH-less heavy chain gene usage and avidity maturation","volume":"182","author":"Rohatgi","year":"2009","journal-title":"J. Immunol."},{"key":"2025031310012099500_r52","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nature06890","article-title":"Rapid cloning of high-affinity human monoclonal antibodies against influenza virus","volume":"453","author":"Wrammert","year":"2008","journal-title":"Nature"},{"key":"2025031310012099500_r53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fimmu.2012.00193","article-title":"Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination","volume":"3","author":"Wu","year":"2012","journal-title":"Front. Immunol."},{"key":"2025031310012099500_r54","doi-asserted-by":"crossref","first-page":"13463","DOI":"10.1073\/pnas.1312146110","article-title":"Genetic measurement of memory B-cell recall using antibody repertoire sequencing","volume":"110","author":"Vollmers","year":"2013","journal-title":"Proc. Natl. Acad. Sci. 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