{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:19:02Z","timestamp":1790061542442,"version":"4.0.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mast cells play critical roles in allergic responses. Calcium signaling controls the function of these cells, and a role for actin in regulating calcium influx into cells has been suggested. We have previously identified the actin reorganizing protein Drebrin as a target of the immunosuppressant 3,5-bistrifluoromethyl pyrazole, which inhibits calcium influx into cells. In this study, we show that Drebrin\u2212\/\u2212 mice exhibit reduced IgE-mediated histamine release and passive systemic anaphylaxis, and Drebrin\u2212\/\u2212 mast cells also exhibit defects in Fc\u03b5RI-mediated degranulation. Drebrin\u2212\/\u2212 mast cells exhibit defects in actin cytoskeleton organization and calcium responses downstream of the Fc\u03b5RI, and agents that relieve actin reorganization rescue mast cell Fc\u03b5RI-induced degranulation. Our results indicate that Drebrin regulates the actin cytoskeleton and calcium responses in mast cells, thus regulating mast cell function in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.1401442","type":"journal-article","created":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T02:47:05Z","timestamp":1433818025000},"page":"426-430","source":"Crossref","is-referenced-by-count":19,"title":["Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses"],"prefix":"10.1093","volume":"195","author":[{"given":"Mankit","family":"Law","sequence":"first","affiliation":[{"name":"Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, PA 16801"},{"name":"Immunology and Infectious Diseases Graduate Program, Huck Institutes of the Life Sciences, The Pennsylvania State University , University Park, PA 16801"},{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongChan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Luis","family":"Morales","sequence":"additional","affiliation":[{"name":"Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, PA 16801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Ning","sequence":"additional","affiliation":[{"name":"Microscopy and Cytometry Facility, Huck Institutes of the Life Sciences, The Pennsylvania State University , University Park, PA 16801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-1131","authenticated-orcid":false,"given":"Weishan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Pabon","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah-Reum","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amie","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chavez","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Mohinta","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-3415","authenticated-orcid":false,"given":"Avery","family":"August","sequence":"additional","affiliation":[{"name":"Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, PA 16801"},{"name":"Immunology and Infectious Diseases Graduate Program, Huck Institutes of the Life Sciences, The Pennsylvania State University , University Park, PA 16801"},{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,15]]},"reference":[{"key":"2025030703425772400_r1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/ni1546","article-title":"Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses","volume":"9","author":"Baba","year":"2008","journal-title":"Nat. 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