{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:55:51Z","timestamp":1768438551086,"version":"3.49.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Virus-specific CD8+ T cells expand dramatically during acute EBV infection, and their persistence is important for lifelong control of EBV-related disease. To better define the generation and maintenance of these effective CD8+ T cell responses, we used microarrays to characterize gene expression in total and EBV-specific CD8+ T cells isolated from the peripheral blood of 10 individuals followed from acute infectious mononucleosis (AIM) into convalescence (CONV). In total CD8+ T cells, differential expression of genes in AIM and CONV was most pronounced among those encoding proteins important in T cell activation\/differentiation, cell division\/metabolism, chemokines\/cytokines and receptors, signaling and transcription factors (TF), immune effector functions, and negative regulators. Within these categories, we identified 28 genes that correlated with CD8+ T cell expansion in response to an acute EBV infection. In EBV-specific CD8+ T cells, we identified 33 genes that were differentially expressed in AIM and CONV. Two important TF, T-bet and eomesodermin, were upregulated and maintained at similar levels in both AIM and CONV; in contrast, protein expression declined from AIM to CONV. Expression of these TF varied among cells with different epitope specificities. Collectively, gene and protein expression patterns suggest that a large proportion, if not a majority of CD8+ T cells in AIM are virus specific, activated, dividing, and primed to exert effector activities. High expression of T-bet and eomesodermin may help to maintain effector mechanisms in activated cells and to enable proliferation and transition to earlier differentiation states in CONV.<\/jats:p>","DOI":"10.4049\/jimmunol.1401513","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T01:59:30Z","timestamp":1443491970000},"page":"4185-4197","source":"Crossref","is-referenced-by-count":22,"title":["A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection"],"prefix":"10.1093","volume":"195","author":[{"given":"Thomas C","family":"Greenough","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juerg R","family":"Straubhaar","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Kamga","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R","family":"Weiss","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin M","family":"Brody","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M","family":"McManus","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda K","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Somasundaran","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine F","family":"Luzuriaga","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"2025030704203246800_r1","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.187.9.1395","article-title":"Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo","volume":"187","author":"Callan","year":"1998","journal-title":"J. Exp. Med."},{"key":"2025030704203246800_r2","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1086\/491740","article-title":"A prospective clinical study of Epstein-Barr virus and host interactions during acute infectious mononucleosis","volume":"192","author":"Balfour","year":"2005","journal-title":"J. Infect. Dis."},{"key":"2025030704203246800_r3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/infdis\/jis646","article-title":"Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students","volume":"207","author":"Balfour","year":"2013","journal-title":"J. Infect. Dis."},{"key":"2025030704203246800_r4","doi-asserted-by":"crossref","first-page":"e1000496","DOI":"10.1371\/journal.ppat.1000496","article-title":"The dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral output","volume":"5","author":"Hadinoto","year":"2009","journal-title":"PLoS Pathog."},{"key":"2025030704203246800_r5","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJM197606172942501","article-title":"Infectious mononucleosis. Epstein-Barr-virus shedding in saliva and the oropharynx","volume":"294","author":"Niederman","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"2025030704203246800_r6","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.4049\/jimmunol.168.8.4184","article-title":"Phenotypic and functional heterogeneity of EBV epitope-specific CD8+ T cells","volume":"168","author":"Catalina","year":"2002","journal-title":"J. Immunol."},{"key":"2025030704203246800_r7","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.4049\/jimmunol.167.4.2019","article-title":"EBV-specific CD8+ T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function","volume":"167","author":"Hislop","year":"2001","journal-title":"J. Immunol."},{"key":"2025030704203246800_r8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1084\/jem.190.4.567","article-title":"Epstein-barr virus-infected resting memory B cells, not proliferating lymphoblasts, accumulate in the peripheral blood of immunosuppressed patients","volume":"190","author":"Babcock","year":"1999","journal-title":"J. Exp. Med."},{"key":"2025030704203246800_r9","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.4049\/jimmunol.179.5.3153","article-title":"Influence of EBV on the peripheral blood memory B cell compartment","volume":"179","author":"Souza","year":"2007","journal-title":"J. Immunol."},{"key":"2025030704203246800_r10","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1056\/NEJMoa043980","article-title":"Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes","volume":"352","author":"Keymeulen","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"2025030704203246800_r11","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1182\/blood-2008-09-178046","article-title":"Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation","volume":"113","author":"Landgren","year":"2009","journal-title":"Blood"},{"key":"2025030704203246800_r12","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.coi.2010.12.014","article-title":"Immune defence against EBV and EBV-associated disease","volume":"23","author":"Long","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"2025030704203246800_r13","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.immuni.2012.08.021","article-title":"Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory","volume":"37","author":"Doering","year":"2012","journal-title":"Immunity"},{"key":"2025030704203246800_r14","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.4049\/jimmunol.181.3.1859","article-title":"Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells","volume":"181","author":"Haining","year":"2008","journal-title":"J. Immunol."},{"key":"2025030704203246800_r15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.immuni.2007.09.006","article-title":"Molecular signature of CD8+ T cell exhaustion during chronic viral infection","volume":"27","author":"Wherry","year":"2007","journal-title":"Immunity"},{"key":"2025030704203246800_r16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/ni.1688","article-title":"Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans","volume":"10","author":"Querec","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030704203246800_r17","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1172\/JCI42758","article-title":"Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation","volume":"120","author":"Hertoghs","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2025030704203246800_r18","doi-asserted-by":"crossref","first-page":"e85422","DOI":"10.1371\/journal.pone.0085422","article-title":"Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes","volume":"9","author":"Dunmire","year":"2014","journal-title":"PLoS One"},{"key":"2025030704203246800_r19","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nm.2232","article-title":"Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF","volume":"16","author":"Quigley","year":"2010","journal-title":"Nat. Med."},{"key":"2025030704203246800_r20","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1084\/jem.20131333","article-title":"Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction","volume":"211","author":"Kurktschiev","year":"2014","journal-title":"J. Exp. Med."},{"key":"2025030704203246800_r21","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.4049\/jimmunol.167.8.4450","article-title":"Differential evolution and stability of epitope-specific CD8+ T cell responses in EBV infection","volume":"167","author":"Catalina","year":"2001","journal-title":"J. Immunol."},{"key":"2025030704203246800_r22","doi-asserted-by":"crossref","first-page":"e12926","DOI":"10.1371\/journal.pone.0012926","article-title":"Programmed death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage","volume":"5","author":"Greenough","year":"2010","journal-title":"PLoS One"},{"key":"2025030704203246800_r23","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1097\/QAD.0b013e3283618487","article-title":"HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127","volume":"27","author":"Hasley","year":"2013","journal-title":"AIDS"},{"key":"2025030704203246800_r24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.21015","article-title":"SPICE: exploration and analysis of post-cytometric complex multivariate datasets","volume":"79","author":"Roederer","year":"2011","journal-title":"Cytometry A"},{"key":"2025030704203246800_r25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nbt1385","article-title":"Direct multiplexed measurement of gene expression with color-coded probe pairs","volume":"26","author":"Geiss","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"2025030704203246800_r26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"2025030704203246800_r27","doi-asserted-by":"crossref","first-page":"e1001057","DOI":"10.1371\/journal.pcbi.1001057","article-title":"Is my network module preserved and reproducible?","volume":"7","author":"Langfelder","year":"2011","journal-title":"PLOS Comput. Biol."},{"key":"2025030704203246800_r28","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/nn.2207","article-title":"Functional organization of the transcriptome in human brain","volume":"11","author":"Oldham","year":"2008","journal-title":"Nat. Neurosci."},{"key":"2025030704203246800_r29","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ng0506-500","article-title":"GenePattern 2.0","volume":"38","author":"Reich","year":"2006","journal-title":"Nat. Genet."},{"key":"2025030704203246800_r30","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1093\/bioinformatics\/bti270","article-title":"Use of within-array replicate spots for assessing differential expression in microarray experiments","volume":"21","author":"Smyth","year":"2005","journal-title":"Bioinformatics"},{"key":"2025030704203246800_r31","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"2025030704203246800_r32"},{"key":"2025030704203246800_r33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2025030704203246800_r34","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1182\/blood-2007-06-093278","article-title":"On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis","volume":"111","author":"Hadinoto","year":"2008","journal-title":"Blood"},{"key":"2025030704203246800_r35","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1084\/jem.20011692","article-title":"Epitope-specific evolution of human CD8+ T cell responses from primary to persistent phases of Epstein-Barr virus infection","volume":"195","author":"Hislop","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025030704203246800_r36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/088282403763635401","article-title":"The evolution of antigen-specific CD8+ T cell responses after natural primary infection of humans with Epstein-Barr virus","volume":"16","author":"Callan","year":"2003","journal-title":"Viral Immunol."},{"key":"2025030704203246800_r37","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.immunol.25.022106.141553","article-title":"Cellular responses to viral infection in humans: lessons from Epstein-Barr virus","volume":"25","author":"Hislop","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"2025030704203246800_r38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-065X.2010.00927.x","article-title":"Transcription factor regulation of CD8+ T-cell memory and exhaustion","volume":"236","author":"Angelosanto","year":"2010","journal-title":"Immunol. Rev."},{"key":"2025030704203246800_r39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ni.1679","article-title":"Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection","volume":"10","author":"Blackburn","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030704203246800_r40","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.4049\/jimmunol.1001783","article-title":"Phenotype, function, and gene expression profiles of programmed death-1hi CD8 T cells in healthy human adults","volume":"186","author":"Duraiswamy","year":"2011","journal-title":"J. Immunol."},{"key":"2025030704203246800_r41","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T cell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2025030704203246800_r42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.0105-2896.2010.00901.x","article-title":"Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation","volume":"235","author":"Rutishauser","year":"2010","journal-title":"Immunol. Rev."},{"key":"2025030704203246800_r43","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.4049\/jimmunol.177.7.4330","article-title":"Three memory subsets of human CD8+ T cells differently expressing three cytolytic effector molecules","volume":"177","author":"Takata","year":"2006","journal-title":"J. Immunol."},{"key":"2025030704203246800_r44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025030704203246800_r45","first-page":"904","article-title":"Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study","volume":"6","author":"Giorgi","year":"1993","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"2025030704203246800_r46","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/00042560-199808010-00004","article-title":"CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency","volume":"18","author":"Liu","year":"1998","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"2025030704203246800_r47","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1009","article-title":"Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells","volume":"4","author":"Kaech","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025030704203246800_r48","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/nm0896-906","article-title":"Large clonal expansions of CD8+ T cells in acute infectious mononucleosis","volume":"2","author":"Callan","year":"1996","journal-title":"Nat. Med."},{"key":"2025030704203246800_r49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.it.2014.01.003","article-title":"Cellular immune controls over Epstein-Barr virus infection: new lessons from the clinic and the laboratory","volume":"35","author":"Rickinson","year":"2014","journal-title":"Trends Immunol."},{"key":"2025030704203246800_r50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nri3156","article-title":"The role of interleukin-2 during homeostasis and activation of the immune system","volume":"12","author":"Boyman","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2025030704203246800_r51","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1182\/blood-2006-06-027060","article-title":"Cartography of gene expression in CD8 single cells: novel CCR7\u2212 subsets suggest differentiation independent of CD45RA expression","volume":"109","author":"Monteiro","year":"2007","journal-title":"Blood"},{"key":"2025030704203246800_r52","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ni.2536","article-title":"Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation","volume":"14","author":"Immunological Genome Project Consortium","year":"2013","journal-title":"Nat. Immunol."},{"key":"2025030704203246800_r53","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"2025030704203246800_r54","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.4049\/jimmunol.1401436","article-title":"T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control","volume":"193","author":"Popescu","year":"2014","journal-title":"J. Immunol."},{"key":"2025030704203246800_r55","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1182\/blood-2010-12-322727","article-title":"Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression","volume":"117","author":"Hersperger","year":"2011","journal-title":"Blood"},{"key":"2025030704203246800_r56","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1172\/JCI25078","article-title":"Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis","volume":"115","author":"Clute","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2025030704203246800_r57","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.4049\/jimmunol.0902168","article-title":"CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections","volume":"184","author":"Cornberg","year":"2010","journal-title":"J. Immunol."},{"key":"2025030704203246800_r58","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.0105-2896.2010.00897.x","article-title":"Heterologous immunity between viruses","volume":"235","author":"Welsh","year":"2010","journal-title":"Immunol. Rev."},{"key":"2025030704203246800_r59","doi-asserted-by":"crossref","first-page":"7406","DOI":"10.4049\/jimmunol.179.11.7406","article-title":"Sensitive gene expression profiling of human T cell subsets reveals parallel post-thymic differentiation for CD4+ and CD8+ lineages","volume":"179","author":"Appay","year":"2007","journal-title":"J. Immunol."},{"key":"2025030704203246800_r60","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.4049\/jimmunol.175.9.5895","article-title":"Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets","volume":"175","author":"Willinger","year":"2005","journal-title":"J. Immunol."},{"key":"2025030704203246800_r61","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.it.2011.01.004","article-title":"Cytokines and the inception of CD8 T cell responses","volume":"32","author":"Cox","year":"2011","journal-title":"Trends Immunol."},{"key":"2025030704203246800_r62","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1182\/blood-2006-01-0144","article-title":"EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15","volume":"108","author":"Sauce","year":"2006","journal-title":"Blood"},{"key":"2025030704203246800_r63","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1086\/510248","article-title":"IL-7R\u03b1 versus CCR7 and CD45 as markers of virus-specific CD8+ T cell differentiation: contrasting pictures in blood and tonsillar lymphoid tissue","volume":"195","author":"Sauce","year":"2007","journal-title":"J. Infect. Dis."},{"key":"2025030704203246800_r64","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/ni.2623","article-title":"GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling","volume":"14","author":"Wang","year":"2013","journal-title":"Nat. Immunol."},{"key":"2025030704203246800_r65","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.4049\/jimmunol.180.8.5309","article-title":"Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1","volume":"180","author":"Chandele","year":"2008","journal-title":"J. Immunol."},{"key":"2025030704203246800_r66","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ni.2046","article-title":"Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection","volume":"12","author":"Kao","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030704203246800_r67","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.2834","article-title":"The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells","volume":"15","author":"Kurachi","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025030704203246800_r68","doi-asserted-by":"crossref","first-page":"e30852","DOI":"10.1371\/journal.pone.0030852","article-title":"Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization","volume":"7","author":"Baitsch","year":"2012","journal-title":"PLoS One"},{"key":"2025030704203246800_r69","doi-asserted-by":"crossref","first-page":"e1000947","DOI":"10.1371\/journal.ppat.1000947","article-title":"Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation","volume":"6","author":"Bengsch","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025030704203246800_r70","doi-asserted-by":"crossref","first-page":"14733","DOI":"10.1073\/pnas.1009731107","article-title":"Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection","volume":"107","author":"Jin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030704203246800_r71","doi-asserted-by":"crossref","first-page":"9068","DOI":"10.1128\/JVI.00141-09","article-title":"Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection","volume":"83","author":"Sauce","year":"2009","journal-title":"J. Virol."},{"key":"2025030704203246800_r72","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.immuni.2009.06.019","article-title":"A role for the transcriptional repressor Blimp-1 in CD8+ T cell exhaustion during chronic viral infection","volume":"31","author":"Shin","year":"2009","journal-title":"Immunity"},{"key":"2025030704203246800_r73","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.2393","article-title":"Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation","volume":"13","author":"van Gisbergen","year":"2012","journal-title":"Nat. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/9\/4185\/62247193\/1401513.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/9\/4185\/62247193\/1401513.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T04:49:38Z","timestamp":1741322978000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/195\/9\/4185\/7973290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,1]]},"references-count":73,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1401513","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,11]]},"published":{"date-parts":[[2015,11,1]]}}}