{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:01:48Z","timestamp":1791842508314,"version":"4.3.4"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NF-\u03baB\u2013inducing kinase (NIK) is a primary regulator of the noncanonical NF-\u03baB signaling pathway, which plays a vital role downstream of BAFF, CD40L, lymphotoxin, and other inflammatory mediators. Germline deletion or inactivation of NIK in mice results in the defective development of B cells and secondary lymphoid organs, but the role of NIK in adult animals has not been studied. To address this, we generated mice containing a conditional allele of NIK. Deletion of NIK in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF. Consistent with this, B cells from mice in which NIK is acutely deleted fail to respond to BAFF stimulation in vitro and in vivo. In addition, mice with induced NIK deletion exhibit a significant decrease in germinal center B cells and serum IgA, which is indicative of roles for NIK in additional pathways beyond BAFF signaling. Our conditional NIK-knockout mice may be broadly useful for assessing the postdevelopmental and cell-specific roles of NIK and the noncanonical NF-\u03baB pathway in mice.<\/jats:p>","DOI":"10.4049\/jimmunol.1401514","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T12:26:16Z","timestamp":1435407976000},"page":"953-964","source":"Crossref","is-referenced-by-count":69,"title":["Conditional Deletion of NF-\u03baB\u2013Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation"],"prefix":"10.1093","volume":"195","author":[{"given":"Hans D","family":"Brightbill","sequence":"first","affiliation":[{"name":"Department of Immunology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet K","family":"Jackman","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Suto","sequence":"additional","affiliation":[{"name":"Department of Translational Immunology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pathology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreedevi","family":"Chalasani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Translational Immunology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meron","family":"Roose-Girma","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedesz","family":"Balazs","sequence":"additional","affiliation":[{"name":"Department of Translational Immunology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary D","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyne P","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Translational Immunology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawren C","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genentech Inc. , South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,8,1]]},"reference":[{"key":"2025030703574316600_r1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu. 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