{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:23:25Z","timestamp":1790267005049,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ongoing clinical trials are evaluating the benefits of systemic blockade of lymphocyte activation gene-3 (LAG-3) signals to improve immunity to tumors. Those studies are founded on the well-established inhibitory role of LAG-3 in regulating CD8+ T cells during chronic virus infection and antitumor responses. However, the T cell response in LAG-3\u2013deficient mice is similar in size and function to that in wild type animals, suggesting LAG-3 has nuanced immune-regulatory functions. We performed a series of adoptive transfer experiments in mice to better understand the T cell\u2013intrinsic functions of LAG-3 in the regulation of CD8+ T cell responses. Our results indicate that LAG-3 expression by CD8+ T cells inhibits their competitive fitness and results in a slightly reduced rate of cell division in comparison with LAG-3\u2013deficient cells. This cell-intrinsic effect of LAG-3 was consistent across both acute and chronic virus infections. These data show that LAG-3 directly modulates the size of the T cell response and support the use of LAG-3 blockade regimens to enhance CD8+ T cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.1401594","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T03:07:24Z","timestamp":1463972844000},"page":"119-127","source":"Crossref","is-referenced-by-count":26,"title":["LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses"],"prefix":"10.1093","volume":"197","author":[{"given":"Kevin D","family":"Cook","sequence":"first","affiliation":[{"name":"Department of Genetics, University of North Carolina School of Medicine , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason K","family":"Whitmire","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina School of Medicine , Chapel Hill, NC 27599"},{"name":"Department of Microbiology and Immunology, University of North Carolina School of Medicine , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"2025030617452351500_r1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. 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