{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:24:11Z","timestamp":1777494251192,"version":"3.51.4"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Listeria monocytogenes is a major cause of mortality resulting from food poisoning in the United States. In mice, C5 has been genetically linked to host resistance to listeriosis. Despite this genetic association, it remains poorly understood how C5 and its activation products, C5a and C5b, confer host protection to this Gram-positive intracellular bacterium. In this article, we show in a systemic infection model that the major receptor for C5a, C5aR1, is required for a normal robust host immune response against L. monocytogenes. In comparison with wild-type mice, C5aR1\u2212\/\u2212 mice had reduced survival and increased bacterial burden in their livers and spleens. Infected C5aR1\u2212\/\u2212 mice exhibited a dramatic reduction in all major subsets of splenocytes, which was associated with elevated caspase-3 activity and increased TUNEL staining. Because type 1 IFN has been reported to impede the host response to L. monocytogenes through the promotion of splenocyte death, we examined the effect of C5aR1 on type 1 IFN expression in vivo. Indeed, serum levels of IFN-\u03b1 and IFN-\u03b2 were significantly elevated in L. monocytogenes\u2013infected C5aR1\u2212\/\u2212 mice. Similarly, the expression of TRAIL, a type 1 IFN target gene and a proapoptotic factor, was elevated in NK cells isolated from infected C5aR1\u2212\/\u2212 mice. Treatment of C5aR1\u2212\/\u2212 mice with a type 1 IFNR blocking Ab resulted in near-complete rescue of L. monocytogenes\u2013induced mortality. Thus, these findings reveal a critical role for C5aR1 in host defense against L. monocytogenes through the suppression of type 1 IFN expression.<\/jats:p>","DOI":"10.4049\/jimmunol.1401750","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T07:17:00Z","timestamp":1412839020000},"page":"5099-5107","source":"Crossref","is-referenced-by-count":25,"title":["The C5a Anaphylatoxin Receptor (C5aR1) Protects against <i>Listeria monocytogenes<\/i> Infection by Inhibiting Type 1 IFN Expression"],"prefix":"10.1093","volume":"193","author":[{"given":"Daniel G","family":"Calame","sequence":"first","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, Research Center for Immunology and Autoimmune Diseases, The University of Texas Health Science Center at Houston , Houston, TX 77030"},{"name":"M.D.\/Ph.D. Program, University of Texas Medical School at Houston\/The University of Texas Graduate School of Biomedical Sciences at Houston , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey L","family":"Mueller-Ortiz","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, Research Center for Immunology and Autoimmune Diseases, The University of Texas Health Science Center at Houston , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E","family":"Morales","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, Research Center for Immunology and Autoimmune Diseases, The University of Texas Health Science Center at Houston , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick A","family":"Wetsel","sequence":"additional","affiliation":[{"name":"The Brown Foundation Institute of Molecular Medicine, Research Center for Immunology and Autoimmune Diseases, The University of Texas Health Science Center at Houston , Houston, TX 77030"},{"name":"Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,11,15]]},"reference":[{"key":"2025030707444325800_r1","doi-asserted-by":"crossref","first-page":"19484","DOI":"10.1073\/pnas.1112371108","article-title":"Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes","volume":"108","author":"Cossart","year":"2011","journal-title":"Proc. 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