{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:47:57Z","timestamp":1777654077221,"version":"3.51.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD40 and BAFFR signaling play important roles in B cell proliferation and Ig production. In this study, we found that B cells from mice with deletion of Dbc1 gene (Dbc1\u2212\/\u2212) show elevated proliferation, and IgG1 and IgA production upon in vitro CD40 and BAFF, but not BCR and LPS stimulation, indicating that DBC1 inhibits CD40\/BAFF-mediated B cell activation in a cell-intrinsic manner. Microarray analysis and chromatin immunoprecipitation experiments reveal that DBC1 inhibits B cell function by selectively suppressing the transcriptional activity of alternative NF-\u03baB members RelB and p52 upon CD40 stimulation. As a result, when immunized with nitrophenylated-keyhole limpet hemocyanin, Dbc1\u2212\/\u2212 mice produce significantly increased levels of germinal center B cells, plasma cells, and Ag-specific Ig. Finally, loss of DBC1 in mice leads to higher susceptibility to experimental autoimmune myasthenia gravis. Our study identifies DBC1 as a novel regulator of B cell activation by suppressing the alternative NF-\u03baB pathway.<\/jats:p>","DOI":"10.4049\/jimmunol.1401798","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T08:54:25Z","timestamp":1414832065000},"page":"5515-5524","source":"Crossref","is-referenced-by-count":16,"title":["DBC1 Is a Suppressor of B Cell Activation by Negatively Regulating Alternative NF-\u03baB Transcriptional Activity"],"prefix":"10.1093","volume":"193","author":[{"given":"Sinyi","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthusamy","family":"Thiruppathi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois College of Medicine , Chicago, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine , Chicago, IL 60611"},{"name":"Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo N","family":"Chini","sequence":"additional","affiliation":[{"name":"Laboratory of Signal Transduction, Department of Anesthesiology and Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine , Rochester, MN 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bellur S","family":"Prabhakar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois College of Medicine , Chicago, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,12,1]]},"reference":[{"key":"2025030707475163600_r1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.immunol.21.120601.141152","article-title":"BAFF AND APRIL: a tutorial on B cell survival","volume":"21","author":"Mackay","year":"2003","journal-title":"Annu. 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