{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:59:52Z","timestamp":1790477992328,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It is unclear why selective deficiency in secreted (s)IgM causes Ab-mediated autoimmunity. We demonstrate that sIgM is required for normal B cell development and selection. The CD5+ B cells that were previously shown to accumulate in body cavities of sIgM\u2212\/\u2212 mice are not B-1a cells, but CD19int, CD43\u2212, short-lived, BCR signaling\u2013unresponsive anergic B-2 cells. Body cavity B-1 cells were &amp;gt;10-fold reduced, including VH11+ and phosphotidylcholine-specific B-1a cells, whereas splenic B-1 cells were unaffected and marginal zone B cells increased. Follicular B cells had higher turnover rates, survived poorly after adoptive transfer, and were unresponsiveness to BCR stimulation in vitro. sIgM bound to B cell precursors and provided a positive signal to overcome a block at the pro\/pre\u2013B stage and during IgVH repertoire selection. Polyclonal IgM rescued B cell development and returned autoantibody levels to near normal. Thus, natural IgM deficiency causes primary autoimmune disease by altering B cell development, selection, and central tolerance induction.<\/jats:p>","DOI":"10.4049\/jimmunol.1401880","type":"journal-article","created":{"date-parts":[[2015,1,17]],"date-time":"2015-01-17T10:44:08Z","timestamp":1421491448000},"page":"1489-1502","source":"Crossref","is-referenced-by-count":86,"title":["Natural IgM Prevents Autoimmunity by Enforcing B Cell Central Tolerance Induction"],"prefix":"10.1093","volume":"194","author":[{"given":"Trang T T","family":"Nguyen","sequence":"first","affiliation":[{"name":"Center for Comparative Medicine, University of California , Davis, Davis, CA 95616"},{"name":"Graduate Group in Immunology, University of California , Davis, Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A","family":"Elsner","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, University of California , Davis, Davis, CA 95616"},{"name":"Microbiology Graduate Group, University of California , Davis, Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Baumgarth","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, University of California , Davis, Davis, CA 95616"},{"name":"Graduate Group in Immunology, University of California , Davis, Davis, CA 95616"},{"name":"Microbiology Graduate Group, University of California , Davis, Davis, CA 95616"},{"name":"Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California , Davis, Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,2,15]]},"reference":[{"key":"2025030705072429100_r1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nri2849","article-title":"The importance of natural IgM: scavenger, protector and regulator","volume":"10","author":"Ehrenstein","year":"2010","journal-title":"Nat. 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