{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:13:12Z","timestamp":1761919992812,"version":"3.38.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We previously showed that LIGHT and its receptor herpes virus entry mediator (HVEM) are important for development of optimal CD4+ Th1 cell immunity and resistance to primary Leishmania major infection in mice. In this study, we further characterized the contributions of this molecule in dendritic cell (DC) maturation, initiation, and maintenance of primary immunity and secondary anti-Leishmania immunity. Flow-cytometric studies showed that CD8\u03b1+ DC subset was mostly affected by HVEM-Ig and lymphotoxin \u03b2 receptor-Ig treatment. LIGHT signaling is required at both the priming and the maintenance stages of primary anti-Leishmania immunity but is completely dispensable during secondary immunity in wild type mice. However, LIGHT blockade led to impaired IL-12 and IFN-\u03b3 responses and loss of resistance in healed CD40-deficient mice after L. major challenge. The protective effect of LIGHT was mediated primarily via its interaction with lymphotoxin \u03b2 receptor on CD8\u03b1+ DCs. Collectively, our results show that although LIGHT is critical for maintenance of primary Th1 response, it is dispensable during secondary anti-Leishmania immunity in the presence of functional CD40 signaling as seen in wild type mice.<\/jats:p>","DOI":"10.4049\/jimmunol.1401892","type":"journal-article","created":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T05:30:09Z","timestamp":1432963809000},"page":"194-202","source":"Crossref","is-referenced-by-count":11,"title":["Deficiency of CD40 Reveals an Important Role for LIGHT in Anti-<i>Leishmania<\/i> Immunity"],"prefix":"10.1093","volume":"195","author":[{"given":"Ifeoma","family":"Okwor","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, University of Manitoba , Winnipeg, Manitoba R3E 0T5 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Third Military Medical University , Chongqing 400038 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-Xin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jude E","family":"Uzonna","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Manitoba , Winnipeg, Manitoba R3E 0T5 ,","place":["Canada"]},{"name":"Department of Immunology, University of Manitoba , Winnipeg, Manitoba R3E 0T5 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2025030703405372800_r1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.iy.13.040195.001055","article-title":"The regulation of immunity to Leishmania major","volume":"13","author":"Reiner","year":"1995","journal-title":"Annu. 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