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Importantly, CD155-mediated signaling induced Th1 development in both humans and mice, as evidenced by production of IFN-\u03b3 and upregulation of Tbx21 transcription; these effects were independent of IL-12 but dependent on NF-\u03baB\u2013induced autocrine IFN-\u03b3 that triggered positive feedback via STAT1 activation. Mice genetically deficient in CD155 or treated with anti-CD155 Ab exhibited attenuated Th1-type contact hypersensitivity. Thus, CD155 plays an important regulatory role in helper T cell differentiation and allergic diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1401942","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T22:42:37Z","timestamp":1431556957000},"page":"5644-5653","source":"Crossref","is-referenced-by-count":23,"title":["CD155 (PVR\/Necl5) Mediates a Costimulatory Signal in CD4+ T Cells and Regulates Allergic Inflammation"],"prefix":"10.1093","volume":"194","author":[{"given":"Yumi","family":"Yamashita-Kanemaru","sequence":"first","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-4803","authenticated-orcid":false,"given":"Satoko","family":"Tahara-Hanaoka","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]},{"name":"Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichiro","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover 30625 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]},{"name":"Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]},{"name":"Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Ibaraki 305-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"2025030706513564600_r1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.coi.2012.07.009","article-title":"Characterization of CD4+ T cell subsets in allergy","volume":"24","author":"Wambre","year":"2012","journal-title":"Curr. 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