{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:28:53Z","timestamp":1791268133827,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The immune and the skeletal system are tightly interconnected, and B lymphocytes are uniquely endowed with osteo-interactive properties. In this context, receptor activator of NF-\u03baB (RANK) ligand (RANKL) plays a pivotal role in lymphoid tissue formation and bone homeostasis. Although murine models lacking RANK or RANKL show defects in B cell number, the role of the RANKL\u2013RANK axis on B physiology is still a matter of debate. In this study, we have characterized in detail B cell compartment in Rankl\u2212\/\u2212 mice, finding a relative expansion of marginal zone B cells, B1 cells, and plasma cells associated with increased Ig serum levels, spontaneous germinal center formation, and hyperresponse to CD40 triggering. Such abnormalities were associated with an increased frequency of regulatory B cells and augmented B cell\u2013derived IL-10 production. Remarkably, in vivo IL-10-R blockade reduced T cell\u2013triggered plasma cell differentiation and restrained the expansion of regulatory B cells. These data point to a novel role of the RANKL\u2013RANK axis in the regulation of B cell homeostasis and highlight an unexpected link between IL-10 CD40 signaling and the RANKL pathway.<\/jats:p>","DOI":"10.4049\/jimmunol.1401977","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T12:46:26Z","timestamp":1427892386000},"page":"4144-4153","source":"Crossref","is-referenced-by-count":13,"title":["IL-10 Critically Modulates B Cell Responsiveness in <i>Rankl\u2212\/\u2212<\/i> Mice"],"prefix":"10.1093","volume":"194","author":[{"given":"Veronica","family":"Marrella","sequence":"first","affiliation":[{"name":"Istituto di Ricerca Genetica e Biomedica, Unit\u00e0 Operativa di Milano, Consiglio Nazionale delle Richerche , 20138 Milan ,","place":["Italy"]},{"name":"Humanitas Clinical and Research Center , 20089 Rozzano ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Lo Iacono","sequence":"additional","affiliation":[{"name":"Istituto di Ricerca Genetica e Biomedica, Unit\u00e0 Operativa di Milano, Consiglio Nazionale delle Richerche , 20138 Milan ,","place":["Italy"]},{"name":"Humanitas Clinical and Research Center , 20089 Rozzano ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Fontana","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, Pathology Unit, University of Brescia , 25121 Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sobacchi","sequence":"additional","affiliation":[{"name":"Istituto di Ricerca Genetica e Biomedica, Unit\u00e0 Operativa di Milano, Consiglio Nazionale delle Richerche , 20138 Milan ,","place":["Italy"]},{"name":"Humanitas Clinical and Research Center , 20089 Rozzano 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