{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:39:03Z","timestamp":1790051943233,"version":"4.0.1"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>HIV-1 infection leads to numerous B cell abnormalities, including hypergammaglobulinemia, nonspecific B cell activation, nonspecific class switching, increased cell turnover, breakage of tolerance, increased immature\/transitional B cells, B cell malignancies, as well as a loss of capacity to generate and maintain memory, all of which contribute to a global impairment of the immune humoral compartment. Several cytokines and soluble factors, which are increased in sera of HIV-1\u2013infected individuals, have been suggested to directly or indirectly contribute to these B cell dysfunctions, and one of these is the B cell\u2013activating factor (BAFF). We report in this study that HIV-1 (X4- and R5-tropic) upregulates BAFF expression and secretion by human monocytes. Moreover, we show that the virus-mediated production of BAFF by monocytes relies on a type I IFN response by a small percentage of plasmacytoid dendritic cells (pDCs) present in the monocyte cultures. HIV-1\u2013induced type I IFN by pDCs triggers BAFF production in both classical and intermediate monocytes, but not in nonclassical monocytes, which nonetheless display a very strong basal BAFF production. We report also that basal BAFF secretion was higher in monocytes obtained from females compared with those from male donors. This study provides a novel mechanistic explanation for the increased BAFF levels observed during HIV-1 infection and highlights the importance of pDC\/monocyte crosstalk to drive BAFF secretion.<\/jats:p>","DOI":"10.4049\/jimmunol.1402147","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T05:17:48Z","timestamp":1422681468000},"page":"2300-2308","source":"Crossref","is-referenced-by-count":32,"title":["HIV-1\u2013Triggered Release of Type I IFN by Plasmacytoid Dendritic Cells Induces BAFF Production in Monocytes"],"prefix":"10.1093","volume":"194","author":[{"given":"Alejandro M","family":"Gomez","sequence":"first","affiliation":[{"name":"Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec - Pavillon Centre Hospitalier de l\u2019Universit\u00e9 Laval , Quebec, Quebec G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Ouellet","sequence":"additional","affiliation":[{"name":"Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec - Pavillon Centre Hospitalier de l\u2019Universit\u00e9 Laval , Quebec, Quebec G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel J","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec - Pavillon Centre Hospitalier de l\u2019Universit\u00e9 Laval , Quebec, Quebec G1V 4G2 ,","place":["Canada"]},{"name":"D\u00e9partement de Microbiologie-Infectiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval , Quebec, Quebec G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"2025030705151177000_r1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJM198308253090803","article-title":"Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome","volume":"309","author":"Lane","year":"1983","journal-title":"N. 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