{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:55:32Z","timestamp":1767117332136,"version":"3.38.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T cells undergo homeostatic expansion and acquire an activated phenotype in lymphopenic microenvironments. Restoration of normal lymphocyte numbers typically re-establishes normal homeostasis, and proinflammatory cytokine production returns to baseline. Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysregulated homeostatic expansion, which manifests as lymphoproliferative disease with autoantibody production. Our previous work revealed that autoreactive B cells lacking RasGRP1 break tolerance early during development, as well as during germinal center responses, suggesting that T cell\u2013independent and T cell\u2013dependent mechanisms are responsible. Examination of whether a particular T cell subset is involved in the breach of B cell tolerance revealed increased Th17 cells in Rasgrp1-deficient mice relative to control mice. Rasgrp1-deficient mice lacking IL-17R had fewer germinal centers, and germinal centers that formed contained fewer autoreactive B cells, suggesting that IL-17 signaling is required for a break in B cell tolerance in germinal centers. Interestingly, a fraction of Th17 cells from Rasgrp1-deficient mice were CXCR5+ and upregulated levels of CD278 coordinate with their appearance in germinal centers, all attributes of T follicular helper cells (Tfh17). To determine whether CD278\u2013CD275 interactions were required for the development of Tfh17 cells and for autoantibody, Rasgrp1-deficient mice were crossed with CD275-deficient mice. Surprisingly, mice deficient in RasGRP1 and CD275 formed Tfh17 cells and germinal centers and produced similar titers of autoantibodies as mice deficient in only RasGRP1. Therefore, these studies suggest that requirements for Tfh cell development change in lymphopenia-associated autoimmune settings.<\/jats:p>","DOI":"10.4049\/jimmunol.1402193","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T01:55:14Z","timestamp":1463450114000},"page":"4935-4946","source":"Crossref","is-referenced-by-count":9,"title":["CD275-Independent IL-17\u2013Producing T Follicular Helper\u2013like Cells in Lymphopenic Autoimmune-Prone Mice"],"prefix":"10.1093","volume":"196","author":[{"given":"Christopher","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of South Alabama , Mobile, AL 36688"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet E","family":"Buhlmann","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of South Alabama , Mobile, AL 36688"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of South Alabama , Mobile, AL 36688"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5713-5369","authenticated-orcid":false,"given":"Robert A","family":"Barrington","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of South Alabama , Mobile, AL 36688"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"key":"2025030702181808500_r1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nm.2110","article-title":"T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis","volume":"16","author":"Axtell","year":"2010","journal-title":"Nat. Med."},{"key":"2025030702181808500_r2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1053\/j.gastro.2004.12.042","article-title":"Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn\u2019s disease","volume":"128","author":"Monteleone","year":"2005","journal-title":"Gastroenterology"},{"key":"2025030702181808500_r3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/ar3251","article-title":"Abnormalities of T cell signaling in systemic lupus erythematosus","volume":"13","author":"Moulton","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"2025030702181808500_r4","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.4049\/jimmunol.182.3.1421","article-title":"B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells","volume":"182","author":"Hu","year":"2009","journal-title":"J. Immunol."},{"key":"2025030702181808500_r5","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.4049\/jimmunol.168.4.2046","article-title":"Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus","volume":"168","author":"Wang","year":"2002","journal-title":"J. Immunol."},{"key":"2025030702181808500_r6","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/art.10273","article-title":"The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus","volume":"46","author":"Huang","year":"2002","journal-title":"Arthritis Rheum."},{"key":"2025030702181808500_r7","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.4049\/jimmunol.0903595","article-title":"Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL\/6-lpr\/lpr mice","volume":"184","author":"Kyttaris","year":"2010","journal-title":"J. Immunol."},{"key":"2025030702181808500_r8","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.4049\/jimmunol.181.9.6038","article-title":"Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25\u2212 LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells","volume":"181","author":"Wu","year":"2008","journal-title":"J. Immunol."},{"key":"2025030702181808500_r9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1177\/0961203308100511","article-title":"Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25\u2212LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells","volume":"18","author":"Wu","year":"2009","journal-title":"Lupus"},{"key":"2025030702181808500_r10","doi-asserted-by":"crossref","first-page":"20200","DOI":"10.1073\/pnas.1313654110","article-title":"Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation","volume":"110","author":"Jones","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702181808500_r11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.immuni.2009.07.002","article-title":"The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment","volume":"31","author":"Yu","year":"2009","journal-title":"Immunity"},{"key":"2025030702181808500_r12","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.4049\/jimmunol.179.8.5099","article-title":"Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation","volume":"179","author":"Haynes","year":"2007","journal-title":"J. Immunol."},{"key":"2025030702181808500_r13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni1238","article-title":"Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues","volume":"6","author":"Debes","year":"2005","journal-title":"Nat. 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Exp. Med."},{"key":"2025030702181808500_r21","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.4049\/jimmunol.0800758","article-title":"ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus","volume":"182","author":"Odegard","year":"2009","journal-title":"J. Immunol."},{"key":"2025030702181808500_r22","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.4049\/jimmunol.175.11.7179","article-title":"RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling","volume":"175","author":"Coughlin","year":"2005","journal-title":"J. Immunol."},{"key":"2025030702181808500_r23","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.4049\/jimmunol.179.7.4890","article-title":"Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus","volume":"179","author":"Yasuda","year":"2007","journal-title":"J. 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Immunol."},{"key":"2025030702181808500_r33","doi-asserted-by":"crossref","first-page":"e38796","DOI":"10.1371\/journal.pone.0038796","article-title":"Regulation of RasGRP1 function in T cell development and activation by its unique tail domain","volume":"7","author":"Fuller","year":"2012","journal-title":"PLoS One"},{"key":"2025030702181808500_r34","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.4049\/jimmunol.180.9.5973","article-title":"Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice","volume":"180","author":"Chen","year":"2008","journal-title":"J. Immunol."},{"key":"2025030702181808500_r35","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.4049\/jimmunol.0901509","article-title":"Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation","volume":"184","author":"Tan","year":"2010","journal-title":"J. Immunol."},{"key":"2025030702181808500_r36","doi-asserted-by":"crossref","first-page":"14292","DOI":"10.1073\/pnas.1009234107","article-title":"Proinflammatory T helper type 17 cells are effective B-cell helpers","volume":"107","author":"Mitsdoerffer","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702181808500_r37","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.4049\/jimmunol.165.6.3136","article-title":"Th1 and Th2 CD4+ T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo","volume":"165","author":"Smith","year":"2000","journal-title":"J. Immunol."},{"key":"2025030702181808500_r38","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/79766","article-title":"RasGRP is essential for mouse thymocyte differentiation and TCR signaling","volume":"1","author":"Dower","year":"2000","journal-title":"Nat. Immunol."},{"key":"2025030702181808500_r39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.immuni.2006.07.014","article-title":"Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice","volume":"25","author":"Berland","year":"2006","journal-title":"Immunity"},{"key":"2025030702181808500_r40","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4049\/jimmunol.138.1.138","article-title":"The NZB X SWR model of lupus nephritis. II. Autoantibodies deposited in renal lesions show a distinctive and restricted idiotypic diversity","volume":"138","author":"Gavalchin","year":"1987","journal-title":"J. Immunol."},{"key":"2025030702181808500_r41","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.177.5.1367","article-title":"Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus","volume":"177","author":"Mohan","year":"1993","journal-title":"J. Exp. Med."},{"key":"2025030702181808500_r42","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.4049\/jimmunol.0903133","article-title":"IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16","volume":"184","author":"Xie","year":"2010","journal-title":"J. Immunol."},{"key":"2025030702181808500_r43","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ni1552","article-title":"Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice","volume":"9","author":"Hsu","year":"2008","journal-title":"Nat. Immunol."},{"key":"2025030702181808500_r44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35051113","article-title":"ICOS is essential for effective T-helper-cell responses","volume":"409","author":"Tafuri","year":"2001","journal-title":"Nature"},{"key":"2025030702181808500_r45","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1182\/blood-2005-07-2955","article-title":"Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency","volume":"107","author":"Warnatz","year":"2006","journal-title":"Blood"},{"key":"2025030702181808500_r46","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1002\/art.38735","article-title":"Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice","volume":"66","author":"Ding","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"2025030702181808500_r47","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.20120994","article-title":"The origins, function, and regulation of T follicular helper cells","volume":"209","author":"Ma","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025030702181808500_r48","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.4049\/jimmunol.1102448","article-title":"Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression","volume":"188","author":"Chen","year":"2012","journal-title":"J. Immunol."},{"key":"2025030702181808500_r49","doi-asserted-by":"crossref","first-page":"e01020","DOI":"10.7554\/eLife.01020","article-title":"Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies","volume":"2","author":"Daley","year":"2013","journal-title":"eLife"},{"key":"2025030702181808500_r50","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2012.02.012","article-title":"Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation","volume":"36","author":"Ballesteros-Tato","year":"2012","journal-title":"Immunity"},{"key":"2025030702181808500_r51","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.181845","article-title":"Selective in vitro growth of T lymphocytes from normal human bone marrows","volume":"193","author":"Morgan","year":"1976","journal-title":"Science"},{"key":"2025030702181808500_r52","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1126\/science.3131876","article-title":"Interleukin-2: inception, impact, and implications","volume":"240","author":"Smith","year":"1988","journal-title":"Science"},{"key":"2025030702181808500_r53","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.immuni.2007.02.009","article-title":"Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation","volume":"26","author":"Laurence","year":"2007","journal-title":"Immunity"},{"key":"2025030702181808500_r54","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1084\/jem.20111174","article-title":"STAT5 is a potent negative regulator of TFH cell differentiation","volume":"209","author":"Johnston","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025030702181808500_r55","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.immuni.2008.05.009","article-title":"Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages","volume":"29","author":"Nurieva","year":"2008","journal-title":"Immunity"},{"key":"2025030702181808500_r56","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.4049\/jimmunol.173.9.5361","article-title":"Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6","volume":"173","author":"Ozaki","year":"2004","journal-title":"J. Immunol."},{"key":"2025030702181808500_r57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.immunol.26.021607.090316","article-title":"Interleukin-21: basic biology and implications for cancer and autoimmunity","volume":"26","author":"Spolski","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"2025030702181808500_r58","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.immuni.2008.12.015","article-title":"Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS","volume":"30","author":"Linterman","year":"2009","journal-title":"Immunity"},{"key":"2025030702181808500_r59","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature03555","article-title":"A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity","volume":"435","author":"Vinuesa","year":"2005","journal-title":"Nature"},{"key":"2025030702181808500_r60","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00296-010-1771-0","article-title":"Elevated Th17 cells are accompanied by FoxP3+ Treg cells decrease in patients with lupus nephritis","volume":"32","author":"Xing","year":"2012","journal-title":"Rheumatol. Int."},{"key":"2025030702181808500_r61","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1186\/ar2964","article-title":"Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus","volume":"12","author":"Shah","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"2025030702181808500_r62","doi-asserted-by":"crossref","first-page":"R150","DOI":"10.1186\/ar3100","article-title":"Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus","volume":"12","author":"Dolff","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"2025030702181808500_r63","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.immuni.2014.02.005","article-title":"Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells","volume":"40","author":"Ray","year":"2014","journal-title":"Immunity"},{"key":"2025030702181808500_r64","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1073\/pnas.95.19.11107","article-title":"Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases","volume":"95","author":"Sengupta","year":"1998","journal-title":"Proc. Natl. Acad. Sci. 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