{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:36:19Z","timestamp":1771544179732,"version":"3.50.1"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eosinophils are versatile cells that regulate innate and adaptive immunity, influence metabolism and tissue repair, and contribute to allergic lung disease. Within the context of immunity to parasitic worm infections, eosinophils are prominent yet highly varied in function. We have shown previously that when mice undergo primary infection with the parasitic nematode Trichinella spiralis, eosinophils play an important immune regulatory role that promotes larval growth and survival in skeletal muscle. In this study, we aimed to address the function of eosinophils in secondary infection with T. spiralis. By infecting eosinophil-ablated mice, we found that eosinophils are dispensable for immunity that clears adult worms or controls fecundity in secondary infection. In contrast, eosinophil ablation had a pronounced effect on secondary infection of skeletal muscle by migratory newborn larvae. Restoring eosinophils to previously infected, ablated mice caused them to limit muscle larvae burdens. Passive immunization of naive, ablated mice with sera or Ig from infected donors, together with transfer of eosinophils, served to limit the number of newborn larvae that migrated in tissue and colonized skeletal muscle. Results from these in vivo studies are consistent with earlier findings that eosinophils bind to larvae in the presence of Abs in vitro. Although our previous findings showed that eosinophils protect the parasite in primary infection, these new data show that eosinophils protect the host in secondary infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1402219","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T05:54:44Z","timestamp":1417067684000},"page":"283-290","source":"Crossref","is-referenced-by-count":53,"title":["Eosinophils Mediate Protective Immunity against Secondary Nematode Infection"],"prefix":"10.1093","volume":"194","author":[{"given":"Lu","family":"Huang","sequence":"first","affiliation":[{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University , Ithaca, NY 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nebiat G","family":"Gebreselassie","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University , Ithaca, NY 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucille F","family":"Gagliardo","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University , Ithaca, NY 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura C","family":"Ruyechan","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University , Ithaca, NY 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kierstin L","family":"Luber","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University , Ithaca, NY 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Division of Hematology\/Oncology, Mayo Clinic Arizona , Scottsdale, AZ 85259"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Division of Pulmonary Medicine, Mayo Clinic Arizona , Scottsdale, AZ 85259"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A","family":"Appleton","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University , Ithaca, NY 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2025031310021086500_r1","author":"Organization"},{"key":"2025031310021086500_r2","doi-asserted-by":"crossref","first-page":"e1621","DOI":"10.1371\/journal.pntd.0001621","article-title":"Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis","volume":"6","author":"Jia","year":"2012","journal-title":"PLoS Negl. 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Microbiol."},{"key":"2025031310021086500_r12","first-page":"103","article-title":"T and B cells in the transfer of immunity against Trichinella spiralis in mice","volume":"37","author":"Wakelin","year":"1979","journal-title":"Immunology"},{"key":"2025031310021086500_r13","doi-asserted-by":"crossref","first-page":"e1003662","DOI":"10.1371\/journal.ppat.1003662","article-title":"IL-4R\u03b1-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection","volume":"9","author":"Horsnell","year":"2013","journal-title":"PLoS Pathog."},{"key":"2025031310021086500_r14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0020-7519(82)90097-2","article-title":"Comparison of rapid expulsion of Trichinella spiralis in mice and rats","volume":"12","author":"Alizadeh","year":"1982","journal-title":"Int. J. Parasitol."},{"key":"2025031310021086500_r15","first-page":"425","article-title":"Release of leukotrienes during rapid expulsion of Trichinella spiralis from immune rats","volume":"60","author":"Moqbel","year":"1987","journal-title":"Immunology"},{"key":"2025031310021086500_r16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1365-3024.1990.tb00996.x","article-title":"Functional correlations between mucosal mast cell activity and immunity to Trichinella spiralis in high and low responder mice","volume":"12","author":"Tuohy","year":"1990","journal-title":"Parasite Immunol."},{"key":"2025031310021086500_r17","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.4049\/jimmunol.0900944","article-title":"Expulsion of secondary Trichinella spiralis infection in rats occurs independently of mucosal mast cell release of mast cell protease II","volume":"183","author":"Blum","year":"2009","journal-title":"J. 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Factors affecting the eosinophil response of rats to Trichinella spiralis","volume":"131","author":"Basten","year":"1970","journal-title":"J. Exp. Med."},{"key":"2025031310021086500_r22","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.4049\/jimmunol.123.5.2220","article-title":"In vitro killing of S. mansoni schistosomula by eosinophils from infected rats: role of cytophilic antibodies","volume":"123","author":"Capron","year":"1979","journal-title":"J. Immunol."},{"key":"2025031310021086500_r23","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1172\/JCI109599","article-title":"Eosinophils versus neutrophils in host defense. Killing of newborn larvae of Trichinella spiralis by human granulocytes in vitro","volume":"64","author":"Bass","year":"1979","journal-title":"J. Clin. 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Immunol."},{"key":"2025031310021086500_r37","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-3024.2000.00328.x","article-title":"Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections","volume":"22","author":"Vallance","year":"2000","journal-title":"Parasite Immunol."},{"key":"2025031310021086500_r38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0014-4894(92)90125-T","article-title":"Trichinella spiralis: dose dependence and kinetics of the mucosal immune response in mice","volume":"75","author":"deVos","year":"1992","journal-title":"Exp. Parasitol."},{"key":"2025031310021086500_r39","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1128\/IAI.01307-12","article-title":"Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis","volume":"81","author":"Scalfone","year":"2013","journal-title":"Infect. 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Med."},{"key":"2025031310021086500_r48","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1365-3024.1995.tb00998.x","article-title":"Immune cytotoxic activity of human eosinophils against Trichinella spiralis newborn larvae","volume":"17","author":"Venturiello","year":"1995","journal-title":"Parasite Immunol."},{"key":"2025031310021086500_r49","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2307\/3282130","article-title":"Comparative toxicity of purified human eosinophil granule proteins for newborn larvae of Trichinella spiralis","volume":"73","author":"Hamann","year":"1987","journal-title":"J. Parasitol."},{"key":"2025031310021086500_r50","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4049\/jimmunol.174.2.628","article-title":"Heterogeneity of expression of IgA receptors by human, mouse, and rat eosinophils","volume":"174","author":"Decot","year":"2005","journal-title":"J. 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