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A pattern recognition receptor, Dectin-1, is expressed on myeloid DCs and known to play important roles in Th17 induction and activation during fungal and certain bacterial infections. In this study, we first demonstrate that human plasmacytoid DCs express Dectin-1 in both mRNA and protein levels. More interestingly, Dectin-1\u2013activated plasmacytoid DCs promote Th2-type T cell responses, whereas Dectin-1\u2013activated myeloid DCs decrease Th2-type T cell responses. Such contrasting outcomes of Th2-type T cell responses by the two DC subsets are mainly due to their distinct abilities to control surface OX40L expression in response to \u03b2-glucan. This study provides new insights for the regulation of host immune responses by Dectin-1 expressed on DCs.<\/jats:p>","DOI":"10.4049\/jimmunol.1402276","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T21:55:32Z","timestamp":1435614932000},"page":"1723-1731","source":"Crossref","is-referenced-by-count":37,"title":["Opposing Roles of Dectin-1 Expressed on Human Plasmacytoid Dendritic Cells and Myeloid Dendritic Cells in Th2 Polarization"],"prefix":"10.1093","volume":"195","author":[{"given":"HyeMee","family":"Joo","sequence":"first","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Upchurch","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"},{"name":"Baylor University, Institute for Biomedical Studies , Waco, TX 76706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ni","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Li","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Xue","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Hori","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Ritsumeikan University , Kusatsu, Shiga 525-8577 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Zurawski","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Zurawski","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"},{"name":"Baylor University, Institute for Biomedical Studies , Waco, TX 76706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangKon","family":"Oh","sequence":"additional","affiliation":[{"name":"Baylor Institute for Immunology Research , Dallas, TX 75204"},{"name":"Baylor University, Institute for Biomedical Studies , Waco, TX 76706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,8,15]]},"reference":[{"key":"2025030704012842500_r1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev.immunol.21.120601.141040","article-title":"Tolerogenic dendritic cells","volume":"21","author":"Steinman","year":"2003","journal-title":"Annu. 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