{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:18:29Z","timestamp":1790518709813,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human CMV (HCMV) infection promotes a variable and persistent expansion of functionally mature NKG2Cbright NK cells. We analyzed NKG2Cbright NK cell responses triggered by Abs from HCMV+ sera against HCMV-infected MRC5 fibroblasts. Specific Abs promoted the degranulation (i.e., CD107a expression) and the production of cytokines (TNF-\u03b1 and IFN-\u03b3) by a significant fraction of NK cells, exceeding the low natural cytotoxicity against HCMV-infected targets. NK cell\u2013mediated Ab-dependent cell-mediated cytotoxicity was limited by viral Ag availability and HLA class I expression on infected cells early postinfection and increased at late stages, overcoming viral immunoevasion strategies. Moreover, the presence of specific IgG triggered the activation of NK cells against Ab-opsonized cell-free HCMV virions. As compared with NKG2A+ NK cells, a significant proportion of NKG2Cbright NK cells was Fc\u03b5R \u03b3-chain defective and highly responsive to Ab-driven activation, being particularly efficient in the production of antiviral cytokines, mainly TNF-\u03b1. Remarkably, the expansion of NKG2Cbright NK cells in HCMV+ subjects was related to the overall magnitude of TNF-\u03b1 and IFN-\u03b3 cytokine secretion upon Ab-dependent and -independent activation. We show the power and sensitivity of the anti-HCMV response resulting from the cooperation between specific Abs and the NKG2Cbright NK-cell subset. Furthermore, we disclose the proinflammatory potential of NKG2Cbright NK cells, a variable that could influence the individual responses to other pathogens and tumors.<\/jats:p>","DOI":"10.4049\/jimmunol.1402281","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T01:09:58Z","timestamp":1423530598000},"page":"2715-2724","source":"Crossref","is-referenced-by-count":114,"title":["Antibody-Mediated Response of NKG2Cbright NK Cells against Human Cytomegalovirus"],"prefix":"10.1093","volume":"194","author":[{"given":"Marcel","family":"Costa-Garcia","sequence":"first","affiliation":[{"name":"Universitat Pompeu Fabra , 08002 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vera","sequence":"additional","affiliation":[{"name":"Universitat Pompeu Fabra , 08002 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Moraru","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro , 28222 Majadahonda ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Vilches","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro , 28222 Majadahonda ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4882-065X","authenticated-orcid":false,"given":"Miguel","family":"L\u00f3pez-Botet","sequence":"additional","affiliation":[{"name":"Universitat Pompeu Fabra , 08002 Barcelona ,","place":["Spain"]},{"name":"Institut Hospital del Mar d\u2019Investigacions M\u00e8diques , 08003 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-0486","authenticated-orcid":false,"given":"Aura","family":"Muntasell","sequence":"additional","affiliation":[{"name":"Institut Hospital del Mar d\u2019Investigacions M\u00e8diques , 08003 Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,15]]},"reference":[{"key":"2025030705235686200_r1","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"Crumpacker","year":"2000"},{"key":"2025030705235686200_r2","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1182\/blood-2008-10-143560","article-title":"How we treat cytomegalovirus in hematopoietic cell transplant recipients","volume":"113","author":"Boeckh","year":"2009","journal-title":"Blood"},{"key":"2025030705235686200_r3","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1056\/NEJMra064928","article-title":"Infection in solid-organ transplant recipients","volume":"357","author":"Fishman","year":"2007","journal-title":"N. 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