{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:13:03Z","timestamp":1789711983008,"version":"4.0.1"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Elevated levels of the transcription factor c-myc are strongly associated with various cancers, and in particular B cell lymphomas. Although many of c-MYC\u2019s functions have been elucidated, its effect on the presentation of Ag through the HLA class II pathway has not been reported previously. This is an issue of considerable importance, given the low immunogenicity of many c-MYC\u2013positive tumors. We report in this paper that increased c-MYC expression has a negative effect on the ability of B cell lymphomas to functionally present Ags\/peptides to CD4+ T cells. This defect was associated with alterations in the expression of distinct cofactors as well as interactions of antigenic peptides with class II molecules required for the presentation of class II\u2013peptide complexes and T cell engagement. Using early passage Burkitt\u2019s lymphoma (BL) tumors and transformed cells, we show that compared with B lymphoblasts, BL cells express decreased levels of the class II editor HLA-DM, lysosomal thiol-reductase GILT, and a 47-kDa enolase-like protein. Functional Ag presentation was partially restored in BL cells treated with a c-MYC inhibitor, demonstrating the impact of this oncogene on Ag recognition. This restoration of HLA class II\u2013mediated Ag presentation in early passage BL tumors\/cells was linked to enhanced HLA-DM expression and a concurrent decrease in HLA-DO in BL cells. Taken together, these results reveal c-MYC exerts suppressive effects at several critical checkpoints in Ag presentation, which contribute to the immunoevasive properties of BL tumors.<\/jats:p>","DOI":"10.4049\/jimmunol.1402382","type":"journal-article","created":{"date-parts":[[2015,1,17]],"date-time":"2015-01-17T05:44:08Z","timestamp":1421473448000},"page":"1434-1445","source":"Crossref","is-referenced-by-count":50,"title":["Elevation of c-MYC Disrupts HLA Class II\u2013Mediated Immune Recognition of Human B Cell Tumors"],"prefix":"10.1093","volume":"194","author":[{"given":"Jason M","family":"God","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center and Children\u2019s Research Institute, Medical University of South Carolina , Charleston, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center and Children\u2019s Research Institute, Medical University of South Carolina , Charleston, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janette","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center and Children\u2019s Research Institute, Medical University of South Carolina , Charleston, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen","family":"Amria","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center and Children\u2019s Research Institute, Medical University of South Carolina , Charleston, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azim","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center and Children\u2019s Research Institute, Medical University of South Carolina , Charleston, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Kempkes","sequence":"additional","affiliation":[{"name":"Department of Gene Vectors, German Research Center for Environmental Health , 81377 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg W","family":"Bornkamm","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology and Tumor Genetics, German Research Center for Environmental Health , 81377 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical University of South Carolina , Charleston, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice S","family":"Blum","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, IN 46202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center and Children\u2019s Research Institute, Medical University of South Carolina , Charleston, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,2,15]]},"reference":[{"key":"2025030705041376400_r1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1128\/jvi.42.3.773-779.1982","article-title":"Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29","volume":"42","author":"Vennstrom","year":"1982","journal-title":"J. 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