{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:27:30Z","timestamp":1791217650007,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\u03b2-Catenin signaling has recently been tied to the emergence of tolerogenic dendritic cells (DCs). In this article, we demonstrate a novel role for \u03b2-catenin in directing DC subset development through IFN regulatory factor 8 (IRF8) activation. We found that splenic DC precursors express \u03b2-catenin, and DCs from mice with CD11c-specific constitutive \u03b2-catenin activation upregulated IRF8 through targeting of the Irf8 promoter, leading to in vivo expansion of IRF8-dependent CD8\u03b1+, plasmacytoid, and CD103+CD11b\u2212 DCs. \u03b2-Catenin\u2013stabilized CD8\u03b1+ DCs secreted elevated IL-12 upon in vitro microbial stimulation, and pharmacological \u03b2-catenin inhibition blocked this response in wild-type cells. Upon infections with Toxoplasma gondii and vaccinia virus, mice with stabilized DC \u03b2-catenin displayed abnormally high Th1 and CD8+ T lymphocyte responses, respectively. Collectively, these results reveal a novel and unexpected function for \u03b2-catenin in programming DC differentiation toward subsets that orchestrate proinflammatory immunity to infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1402453","type":"journal-article","created":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T06:18:07Z","timestamp":1416637087000},"page":"210-222","source":"Crossref","is-referenced-by-count":38,"title":["\u03b2-Catenin Signaling Drives Differentiation and Proinflammatory Function of IRF8-Dependent Dendritic Cells"],"prefix":"10.1093","volume":"194","author":[{"given":"Sara B","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine , Ithaca, NY 14867"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah L","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine , Ithaca, NY 14867"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"McDougal","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine , Ithaca, NY 14867"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Pepper","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington School of Medicine , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhagi","family":"Shah","sequence":"additional","affiliation":[{"name":"Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey , Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S","family":"Yap","sequence":"additional","affiliation":[{"name":"Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey , Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Acha-Orbea","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne , CH-1066 Epalinges ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Roswell Park Cancer Institute , Buffalo, NY 14263"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2484-7842","authenticated-orcid":false,"given":"Bj\u00f6rn E","family":"Clausen","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz , 55131 Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D","family":"Rudd","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine , Ithaca, NY 14867"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y","family":"Denkers","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine , Ithaca, NY 14867"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2025031310004694400_r1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu. 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