{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:59:26Z","timestamp":1789430366083,"version":"build-2803163510"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Helminths exploit intrinsic regulatory pathways of the mammalian immune system to dampen the immune response directed against them. In this article, we show that infection with the parasitic nematode Strongyloides ratti induced upregulation of the coinhibitory receptor B and T lymphocyte attenuator (BTLA) predominantly on CD4+ T cells but also on a small fraction of innate leukocytes. Deficiency of either BTLA or its ligand herpes virus entry mediator (HVEM) resulted in reduced numbers of parasitic adults in the small intestine and reduced larval output throughout infection. Reduced parasite burden in BTLA- and HVEM-deficient mice was accompanied by accelerated degranulation of mucosal mast cells and increased Ag-specific production of the mast cell\u2013activating cytokine IL-9. Our combined results support a model whereby BTLA on CD4+ T cells and additional innate leukocytes is triggered by HVEM and delivers negative signals into BTLA+ cells, thereby interfering with the protective immune response to this intestinal parasite.<\/jats:p>","DOI":"10.4049\/jimmunol.1402510","type":"journal-article","created":{"date-parts":[[2015,1,17]],"date-time":"2015-01-17T10:44:08Z","timestamp":1421491448000},"page":"1413-1416","source":"Crossref","is-referenced-by-count":35,"title":["Cutting Edge: The BTLA\u2013HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection"],"prefix":"10.1093","volume":"194","author":[{"given":"Minka","family":"Breloer","sequence":"first","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Blankenhaus","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Luise","family":"Eschbach","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"University Hospital D\u00fcsseldorf , 40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,2,15]]},"reference":[{"key":"2025030705051193400_r1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev-immunol-030409-101202","article-title":"Slow down and survive: Enigmatic immunoregulation by BTLA and HVEM","volume":"28","author":"Murphy","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"2025030705051193400_r2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ni944","article-title":"BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1","volume":"4","author":"Watanabe","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025030705051193400_r3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/ni1144","article-title":"B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator","volume":"6","author":"Sedy","year":"2005","journal-title":"Nat. Immunol."},{"key":"2025030705051193400_r4","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.4049\/jimmunol.174.6.3377","article-title":"B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in anergic CD4+ T cells","volume":"174","author":"Hurchla","year":"2005","journal-title":"J. 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