{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:54:16Z","timestamp":1790380456224,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Understanding the cellular populations and mechanisms responsible for overcoming immune compartmentalization is valuable for designing vaccination strategies targeting distal mucosae. In this study, we show that the human pathogen Chlamydia trachomatis infects the murine respiratory and genital mucosae and that T cells, but not Abs, elicited through intranasal immunization can protect against a subsequent transcervical challenge. Unlike the genital infection where CD8+ T cells are primed, yet fail to confer protection, we found that intranasal priming engages both CD4+ and CD8+ T cells, allowing for protection against genital infection with C. trachomatis. The protection is largely dependent on IFN-\u03b3 secretion by T cells. Moreover, different chemokine receptors are critical for C. trachomatis\u2013specific CD4+ T cells to home to the lung, rather than the CXCR3- and CCR5-dependent migration observed during genital infection. Overall, this study demonstrates that the cross-mucosa protective immunity against genital C. trachomatis infection following intranasal immunization is not dependent on Ab response but is mediated by not only CD4+ T cells but also by CD8+ T cells. This study provides insights for the development of vaccines against mucosal pathogens that threaten reproductive health worldwide.<\/jats:p>","DOI":"10.4049\/jimmunol.1402675","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T05:17:48Z","timestamp":1422681468000},"page":"2319-2329","source":"Crossref","is-referenced-by-count":31,"title":["Protective Immunity against <i>Chlamydia trachomatis<\/i> Can Engage Both CD4+ and CD8+ T Cells and Bridge the Respiratory and Genital Mucosae"],"prefix":"10.1093","volume":"194","author":[{"given":"Catarina V","family":"Nogueira","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Giovannone","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica L","family":"Sennott","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N","family":"Starnbach","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"2025030705164713000_r1","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1128\/JVI.80.8.3732-3742.2006","article-title":"Systemic immunization with an ALVAC-HIV-1\/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels","volume":"80","author":"Pal","year":"2006","journal-title":"J. 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