{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:11:57Z","timestamp":1792264317563,"version":"4.4.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aberrant levels and function of the potent anti-inflammatory high-density lipoprotein (HDL) and accelerated atherosclerosis have been reported in patients with autoimmune inflammatory diseases. Whether HDL affects the development of an autoimmune response remains elusive. In this study, we used apolipoprotein A-I\u2013deficient (apoA-I\u2212\/\u2212) mice, characterized by diminished circulating HDL levels, to delineate the role of HDL in autoimmunity. ApoA-I\u2212\/\u2212 mice exhibited increased severity of Ag-induced arthritis compared with wild-type mice, and this was associated with elevated Th1 and Th17 cell reactivity in the draining lymph nodes. Furthermore, reconstituted HDL (rHDL) attenuated IFN-\u03b3 and IL-17 secretion by Ag-specific T cells upon stimulation of draining lymph nodes in vitro. The suppressive effects of rHDL were mediated through modulation of dendritic cell (DC) function. Specifically, rHDL-treated DCs demonstrated an immature phenotype characterized by downregulated costimulatory molecules, the release of low amounts of proinflammatory cytokines, and failure to promote T cell proliferation in vitro. The mechanism of action involved the inhibition of NF-\u03baB nuclear translocation and the decrease of Myd88 mRNA levels by rHDL. Finally, modulation of DC function by rHDL was critically dependent on the presence of scavenger receptor class B type I and ATP Binding Cassette Transporter A1, but not the ATP Binding Cassette Transporter G1. These findings reveal a novel role of HDL in the regulation of adaptive inflammatory responses through suppression of DC function that could be exploited therapeutically in autoimmune inflammatory diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1402870","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T02:06:14Z","timestamp":1428977174000},"page":"4676-4687","source":"Crossref","is-referenced-by-count":61,"title":["High-Density Lipoprotein Attenuates Th1 and Th17 Autoimmune Responses by Modulating Dendritic Cell Maturation and Function"],"prefix":"10.1093","volume":"194","author":[{"given":"Ioanna","family":"Tiniakou","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry, Department of Basic Sciences, University of Crete Medical School , 71003 Heraklion, Crete ,","place":["Greece"]},{"name":"Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology\u2013Hellas , 70013 Heraklion, Crete ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Drakos","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Crete Medical School , 71003 Heraklion, Crete ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaios","family":"Sinatkas","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Crete Medical School , 71003 Heraklion, Crete ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Van Eck","sequence":"additional","affiliation":[{"name":"Division of Biopharmaceutics, Leiden Academic Centre for Drug Research , 2333 Leiden ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis I","family":"Zannis","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Basic Sciences, University of Crete Medical School , 71003 Heraklion, Crete ,","place":["Greece"]},{"name":"Whitaker Cardiovascular Institute, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Boumpas","sequence":"additional","affiliation":[{"name":"Biomedical Research Foundation, Academy of Athens , 11527 Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayotis","family":"Verginis","sequence":"additional","affiliation":[{"name":"Biomedical Research Foundation, Academy of Athens , 11527 Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Kardassis","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Department of Basic Sciences, University of Crete Medical School , 71003 Heraklion, Crete ,","place":["Greece"]},{"name":"Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology\u2013Hellas , 70013 Heraklion, Crete ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,5,15]]},"reference":[{"key":"2025030706252754100_r1","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1194\/jlr.R035725","article-title":"Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond","volume":"54","author":"Shah","year":"2013","journal-title":"J. Lipid Res."},{"key":"2025030706252754100_r2","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1056\/NEJM198911093211907","article-title":"High-density lipoprotein\u2014the clinical implications of recent studies","volume":"321","author":"Gordon","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"2025030706252754100_r3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0002-9343(77)90874-9","article-title":"High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study","volume":"62","author":"Gordon","year":"1977","journal-title":"Am. J. Med."},{"key":"2025030706252754100_r4","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1194\/jlr.R037762","article-title":"High density lipoproteins and endothelial functions: mechanistic insights and alterations in cardiovascular disease","volume":"54","author":"Riwanto","year":"2013","journal-title":"J. Lipid Res."},{"key":"2025030706252754100_r5","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1161\/ATVBAHA.112.300135","article-title":"High density lipoprotein biogenesis, cholesterol efflux, and immune cell function","volume":"32","author":"Sorci-Thomas","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025030706252754100_r6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00109-005-0030-4","article-title":"Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL","volume":"84","author":"Zannis","year":"2006","journal-title":"J. Mol. Med."},{"key":"2025030706252754100_r7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/ATVBAHA.108.179283","article-title":"Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses","volume":"30","author":"Yvan-Charvet","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025030706252754100_r8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/MOL.0b013e3283508c09","article-title":"Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I","volume":"23","author":"Hoekstra","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"2025030706252754100_r9","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1194\/jlr.R039479","article-title":"Regulation of signal transduction by HDL","volume":"54","author":"Mineo","year":"2013","journal-title":"J. Lipid Res."},{"key":"2025030706252754100_r10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1161\/CIRCRESAHA.114.300935","article-title":"High-density lipoprotein: vascular protective effects, dysfunction, and potential as therapeutic target","volume":"114","author":"L\u00fcscher","year":"2014","journal-title":"Circ. Res."},{"key":"2025030706252754100_r11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/ar2471","article-title":"Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis","volume":"10","author":"Hahn","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"2025030706252754100_r12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/cvr\/cvu150","article-title":"HDL in innate and adaptive immunity","volume":"103","author":"Catapano","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"2025030706252754100_r13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81109-5","article-title":"Rheumatoid arthritis","volume":"85","author":"Feldmann","year":"1996","journal-title":"Cell"},{"key":"2025030706252754100_r14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"2025030706252754100_r15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"McInnes","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2025030706252754100_r16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrrheum.2013.91","article-title":"Changes in lipid levels with inflammation and therapy in RA: a maturing paradigm","volume":"9","author":"Robertson","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"2025030706252754100_r17","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1002\/art.24802","article-title":"Abnormal function of high-density lipoprotein is associated with poor disease control and an altered protein cargo in rheumatoid arthritis","volume":"60","author":"Charles-Schoeman","year":"2009","journal-title":"Arthritis Rheum."},{"key":"2025030706252754100_r18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.clim.2008.01.016","article-title":"Treatment with an apolipoprotein A-1 mimetic peptide in combination with pravastatin inhibits collagen-induced arthritis","volume":"127","author":"Charles-Schoeman","year":"2008","journal-title":"Clin. Immunol."},{"key":"2025030706252754100_r19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/ATVBAHA.113.302832","article-title":"Inhibition of arthritis in the Lewis rat by apolipoprotein A-I and reconstituted high-density lipoproteins","volume":"34","author":"Wu","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025030706252754100_r20","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.20.100301.064828","article-title":"Antigen presentation and T cell stimulation by dendritic cells","volume":"20","author":"Guermonprez","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"2025030706252754100_r21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/ni794","article-title":"T-bet is a STAT1-induced regulator of IL-12R expression in na\u00efve CD4+ T cells","volume":"3","author":"Afkarian","year":"2002","journal-title":"Nat. Immunol."},{"key":"2025030706252754100_r22","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature05969","article-title":"Essential autocrine regulation by IL-21 in the generation of inflammatory T cells","volume":"448","author":"Nurieva","year":"2007","journal-title":"Nature"},{"key":"2025030706252754100_r23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"2025030706252754100_r24","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.97.8.4245","article-title":"High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1","volume":"97","author":"McNeish","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030706252754100_r25","doi-asserted-by":"crossref","first-page":"12610","DOI":"10.1073\/pnas.94.23.12610","article-title":"A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism","volume":"94","author":"Rigotti","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030706252754100_r26","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1021\/bi049782p","article-title":"Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice","volume":"43","author":"Chroni","year":"2004","journal-title":"Biochemistry"},{"key":"2025030706252754100_r27","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1016\/S0021-9258(18)34756-2","article-title":"Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions","volume":"257","author":"Matz","year":"1982","journal-title":"J. Biol. Chem."},{"key":"2025030706252754100_r28","doi-asserted-by":"crossref","first-page":"17511","DOI":"10.1074\/jbc.272.28.17511","article-title":"The carboxyl-terminal hydrophobic residues of apolipoprotein A-I affect its rate of phospholipid binding and its association with high density lipoprotein","volume":"272","author":"Laccotripe","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2025030706252754100_r29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0005-2760(93)90253-6","article-title":"Two-dimensional electrophoresis of plasma lipoproteins: recognition of new apo A-I-containing subpopulations","volume":"1169","author":"Asztalos","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"2025030706252754100_r30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/978-1-60327-369-5_17","article-title":"Native-native 2D gel electrophoresis for HDL subpopulation analysis","volume":"1027","author":"Freeman","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"2025030706252754100_r31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"2025030706252754100_r32","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1084\/jem.180.6.2089","article-title":"Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen","volume":"180","author":"Zal","year":"1994","journal-title":"J. Exp. Med."},{"key":"2025030706252754100_r33","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1073\/pnas.89.15.7134","article-title":"Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I","volume":"89","author":"Williamson","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030706252754100_r34","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/eji.201040646","article-title":"The negative costimulatory molecule PD-1 modulates the balance between immunity and tolerance via miR-21","volume":"41","author":"Iliopoulos","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"2025030706252754100_r35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-59745-402-5_18","article-title":"Murine antigen-induced arthritis","volume":"136","author":"van den Berg","year":"2007","journal-title":"Methods Mol. Med."},{"key":"2025030706252754100_r36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/ar1478","article-title":"The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models","volume":"7","author":"Lubberts","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"2025030706252754100_r37","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1053\/berh.2001.0187","article-title":"The balance of Th1\/Th2 cytokines in rheumatoid arthritis","volume":"15","author":"Schulze-Koops","year":"2001","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"2025030706252754100_r38","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"2025030706252754100_r39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"2025030706252754100_r40","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ni.2784","article-title":"High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3","volume":"15","author":"De Nardo","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025030706252754100_r41","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.bbrc.2005.10.065","article-title":"Apolipoprotein A-I induces IL-10 and PGE2 production in human monocytes and inhibits dendritic cell differentiation and maturation","volume":"338","author":"Kim","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030706252754100_r42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.imbio.2011.07.030","article-title":"High-density lipoprotein phospholipids interfere with dendritic cell Th1 functional maturation","volume":"217","author":"Perrin-Cocon","year":"2012","journal-title":"Immunobiology"},{"key":"2025030706252754100_r43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.immuni.2009.12.006","article-title":"In vivo requirement for Atg5 in antigen presentation by dendritic cells","volume":"32","author":"Lee","year":"2010","journal-title":"Immunity"},{"key":"2025030706252754100_r44","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.22.012703.104538","article-title":"Cell biology of antigen processing in vitro and in vivo","volume":"23","author":"Trombetta","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"2025030706252754100_r45","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/cdd.2010.149","article-title":"HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs","volume":"18","author":"Muller","year":"2011","journal-title":"Cell Death Differ."},{"key":"2025030706252754100_r46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20011341","article-title":"Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity","volume":"195","author":"Menges","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025030706252754100_r47","doi-asserted-by":"crossref","first-page":"7433","DOI":"10.4049\/jimmunol.174.11.7433","article-title":"Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cells","volume":"174","author":"Verginis","year":"2005","journal-title":"J. Immunol."},{"key":"2025030706252754100_r48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.20040165","article-title":"Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy","volume":"200","author":"Ehrenstein","year":"2004","journal-title":"J. Exp. Med."},{"key":"2025030706252754100_r49","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nm1564","article-title":"Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation","volume":"13","author":"Korn","year":"2007","journal-title":"Nat. Med."},{"key":"2025030706252754100_r50","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1161\/ATVBAHA.108.183442","article-title":"Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity","volume":"29","author":"Wilhelm","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025030706252754100_r51","doi-asserted-by":"crossref","first-page":"36158","DOI":"10.1074\/jbc.M110.134130","article-title":"Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-\/-, ApoA-I-\/- mice","volume":"285","author":"Wilhelm","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2025030706252754100_r52","doi-asserted-by":"crossref","first-page":"12040","DOI":"10.1073\/pnas.90.24.12040","article-title":"In vivo protection against endotoxin by plasma high density lipoprotein","volume":"90","author":"Levine","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030706252754100_r53","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1194\/jlr.M700446-JLR200","article-title":"Effect of lipid-bound apoA-I cysteine mutants on lipopolysaccharide-induced endotoxemia in mice","volume":"49","author":"Wang","year":"2008","journal-title":"J. Lipid Res."},{"key":"2025030706252754100_r54","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1161\/CIRCULATIONAHA.110.961193","article-title":"High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide","volume":"122","author":"Suzuki","year":"2010","journal-title":"Circulation"},{"key":"2025030706252754100_r55","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1016\/j.febslet.2014.05.047","article-title":"Membrane microdomains in immunoreceptor signaling","volume":"588","author":"Horejsi","year":"2014","journal-title":"FEBS Lett."},{"key":"2025030706252754100_r56","doi-asserted-by":"crossref","first-page":"C1538","DOI":"10.1152\/ajpcell.00467.2009","article-title":"Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages","volume":"298","author":"Smythies","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2025030706252754100_r57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.atherosclerosis.2012.07.029","article-title":"HDL and ApoA-I inhibit antigen presentation-mediated T cell activation by disrupting lipid rafts in antigen presenting cells","volume":"225","author":"Wang","year":"2012","journal-title":"Atherosclerosis"},{"key":"2025030706252754100_r58","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.bbalip.2010.08.006","article-title":"A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways","volume":"1801","author":"Al-Jarallah","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"2025030706252754100_r59","doi-asserted-by":"crossref","first-page":"32336","DOI":"10.1074\/jbc.M109.047472","article-title":"The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor","volume":"284","author":"Tang","year":"2009","journal-title":"J. Biol. Chem."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/194\/10\/4676\/62233821\/1402870.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/194\/10\/4676\/62233821\/1402870.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T07:24:56Z","timestamp":1741332296000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/194\/10\/4676\/7960966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,5,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1402870","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,5]]},"published":{"date-parts":[[2015,5]]}}}