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To investigate the role of CD81 in the regulation of defense mechanisms against microbial infections, we have used the Listeria monocytogenes infection model to explore the impact of CD81 deficiency in the innate and adaptive immune response against this pathogenic bacteria. We show that CD81\u2212\/\u2212 mice are less susceptible than wild-type mice to systemic Listeria infection, which correlates with increased numbers of inflammatory monocytes and DCs in CD81\u2212\/\u2212 spleens, the main subsets controlling early bacterial burden. Additionally, our data reveal that CD81 inhibits Rac\/STAT-1 activation, leading to a negative regulation of the production of TNF-\u03b1 and NO by inflammatory DCs and the activation of cytotoxic T cells by splenic CD8\u03b1+ DCs. In conclusion, this study demonstrates that CD81\u2013Rac interaction exerts an important regulatory role on the innate and adaptive immunity against bacterial infection and suggests a role for CD81 in the development of novel therapeutic targets during infectious diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1402957","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T02:42:37Z","timestamp":1431571357000},"page":"6090-6101","source":"Crossref","is-referenced-by-count":19,"title":["CD81 Controls Immunity to <i>Listeria<\/i> Infection through Rac-Dependent Inhibition of Proinflammatory Mediator Release and Activation of Cytotoxic T Cells"],"prefix":"10.1093","volume":"194","author":[{"given":"Gloria","family":"Mart\u00ednez del Hoyo","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Vascular e Inflamaci\u00f3n, Fundaci\u00f3n Centro Nacional de Investigaciones Cardiovasculares , 28029 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ram\u00edrez-Huesca","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Vascular e Inflamaci\u00f3n, Fundaci\u00f3n Centro Nacional de Investigaciones Cardiovasculares , 28029 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine, Stanford University School of Medicine , Stanford, CA 94035"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Boucheix","sequence":"additional","affiliation":[{"name":"INSERM, Universit\u00e9 Paris-Sud, Institut Andr\u00e9 Lwoff , 94807 Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"INSERM, Universit\u00e9 Paris-Sud, Institut Andr\u00e9 Lwoff , 94807 Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Minguito de la Escalera","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda y Oncolog\u00eda, Centro Nacional de Biotecnolog\u00eda, Consejo Superior de Investigaciones Cient\u00edficas , 28049 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Gonz\u00e1lez-Cintado","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda y Oncolog\u00eda, Centro Nacional de Biotecnolog\u00eda, Consejo Superior de Investigaciones Cient\u00edficas , 28049 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ardav\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda y Oncolog\u00eda, Centro Nacional de Biotecnolog\u00eda, Consejo Superior de Investigaciones Cient\u00edficas , 28049 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Veiga","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Santa Cristina, Instituto de Investigaci\u00f3n Sanitaria Princesa , 28009 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Y\u00e1\u00f1ez-M\u00f3","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Santa Cristina, Instituto de Investigaci\u00f3n Sanitaria Princesa , 28009 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"S\u00e1nchez-Madrid","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Vascular e Inflamaci\u00f3n, Fundaci\u00f3n Centro Nacional de Investigaciones Cardiovasculares , 28029 Madrid ,","place":["Spain"]},{"name":"Servicio de Inmunolog\u00eda, Hospital de la Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa , 28006 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"2025030706503974300_r1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrm1736","article-title":"Tetraspanin functions and associated microdomains","volume":"6","author":"Hemler","year":"2005","journal-title":"Nat. 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