{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:26:48Z","timestamp":1790519208117,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cysteinyl leukotrienes (cysLTs) are bronchoconstricting lipid mediators that amplify eosinophilic airway inflammation by incompletely understood mechanisms. We recently found that LTC4, the parent cysLT, potently activates platelets in vitro and induces airway eosinophilia in allergen-sensitized and -challenged mice by a platelet- and type 2 cysLT receptor\u2013dependent pathway. We now demonstrate that this pathway requires production of thromboxane A2 and signaling through both hematopoietic and lung tissue\u2013associated T prostanoid (TP) receptors. Intranasal administration of LTC4 to OVA-sensitized C57BL\/6 mice markedly increased the numbers of eosinophils in the bronchoalveolar lavage fluid, while simultaneously decreasing the percentages of eosinophils in the blood by a TP receptor\u2013dependent mechanism. LTC4 upregulated the expressions of ICAM-1 and VCAM-1 in an aspirin-sensitive and TP receptor\u2013dependent manner. Both hematopoietic and nonhematopoietic TP receptors were essential for LTC4 to induce eosinophil recruitment. Thus, the autocrine and paracrine functions of thromboxane A2 act downstream of LTC4\/type 2 cysLT receptor signaling on platelets to markedly amplify eosinophil recruitment through pulmonary vascular adhesion pathways. The findings suggest applications for TP receptor antagonists in cases of asthma with high levels of cysLT production.<\/jats:p>","DOI":"10.4049\/jimmunol.1402959","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T02:32:00Z","timestamp":1429756320000},"page":"5061-5068","source":"Crossref","is-referenced-by-count":22,"title":["Platelet-Driven Leukotriene C4\u2013Mediated Airway Inflammation in Mice Is Aspirin-Sensitive and Depends on T Prostanoid Receptors"],"prefix":"10.1093","volume":"194","author":[{"given":"Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicine, Harvard Medical School , Boston, MA 02115"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA 02115"},{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Garofalo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juying","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School , Boston, MA 02115"},{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya M","family":"Laidlaw","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School , Boston, MA 02115"},{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"},{"name":"Jeff and Penny Vinik Center for Allergic Disease Research , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A","family":"Boyce","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School , Boston, MA 02115"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA 02115"},{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women\u2019s Hospital , Boston, MA 02115"},{"name":"Jeff and Penny Vinik Center for Allergic Disease Research , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"2025030706314251600_r1","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.1073\/pnas.91.16.7663","article-title":"Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4","volume":"91","author":"Lam","year":"1994","journal-title":"Proc. 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