{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T14:30:46Z","timestamp":1744209046764,"version":"3.38.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Renal transplant is the treatment of choice for patients with terminal end-stage renal disease. We have previously identified low levels of catalytic IgG as a potential prognosis marker for chronic allograft rejection. The origin and physiopathological relevance of catalytic Abs is not well understood, owing to the fact that catalytic Abs have been studied in relatively small cohorts of patients with rare diseases and\/or without systematic follow-up. In the current study, we have followed the evolution of the levels of catalytic IgG in a large cohort of renal transplant patients over a 2-y period. Our results demonstrate that, prior to transplant, patients with renal failure present with heterogeneous levels of IgG hydrolyzing the generic proline-phenylalanine-arginine-methylcoumarinamide (PFR-MCA) substrate. PFR-MCA hydrolysis was greater for patients\u2019 IgG than for a therapeutic preparation of pooled IgG from healthy donors. Renal transplant was marked by a drastic decrease in levels of catalytic IgG over 3 mo followed by a steady increase during the next 21 mo. Patients who displayed high levels of catalytic IgG pretransplant recovered high levels of catalytic Abs 2 y posttransplant. Interestingly, IgG-mediated hydrolysis of a model protein substrate, procoagulant factor VIII, did not correlate with that of PFR-MCA prior transplantation, whereas it did 12 mo posttransplant. Taken together, our results suggest that the level of circulating catalytic IgG under pathological conditions is an intrinsic property of each individual\u2019s immune system and that recovery of pretransplant levels of catalytic IgG is accompanied by changes in the repertoire of target Ags.<\/jats:p>","DOI":"10.4049\/jimmunol.1403005","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T03:18:16Z","timestamp":1460431096000},"page":"4075-4081","source":"Crossref","is-referenced-by-count":3,"title":["Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual\u2019s Immune System: A Study on a Large Cohort of Renal Transplant Patients"],"prefix":"10.1093","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6664-5974","authenticated-orcid":false,"given":"Ankit","family":"Mahendra","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 06, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"INSERM, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3843-642X","authenticated-orcid":false,"given":"Ivan","family":"Peyron","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 06, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"INSERM, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Thaunat","sequence":"additional","affiliation":[{"name":"INSERM, U1111 , F-69007 Lyon ,","place":["France"]},{"name":"Service de Transplantation, N\u00e9phrologie et Immunologie Clinique, Hospices Civils de Lyon, H\u00f4pital Edouard Herriot , F-69003 Lyon ,","place":["France"]},{"name":"Universit\u00e9 de Lyon , F-69007 Lyon ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Dollinger","sequence":"additional","affiliation":[{"name":"INSERM, U1111 , F-69007 Lyon ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Gilardin","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 06, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"INSERM, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenu","family":"Sharma","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 06, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"INSERM, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7522-1121","authenticated-orcid":false,"given":"Bharath","family":"Wootla","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic College of Medicine , Rochester, MN 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desirazu N","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Indian Institute of Science , Bangalore 560012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5475-1358","authenticated-orcid":false,"given":"S\u00e9verine","family":"Padiolleau-Lefevre","sequence":"additional","affiliation":[{"name":"G\u00e9nie Enzymatique et Cellulaire, Formation de Recherche en Evolution 3580 Centre National de la Recherche Scientifique, Universit\u00e9 de Technologie de Compi\u00e8gne , F-60203 Compi\u00e8gne ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Boquet","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie et d\u2019Immunoanalyse, Laboratoire d\u2019Ing\u00e9nierie des Anticorps pour la Sant\u00e9, Commissariat a l\u2019\u00c9nergie Atomique, Institut de Biologie et de Technologies de Saclay, Saclay , F-91191 Gif-sur-Yvette ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit","family":"More","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of Houston , Houston, TX 77204"},{"name":"Department of Biology and Biochemistry, University of Houston , Houston, TX 77204"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-8228","authenticated-orcid":false,"given":"Navin","family":"Varadarajan","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, University of Houston , Houston, TX 77204"},{"name":"Department of Biology and Biochemistry, University of Houston , Houston, TX 77204"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0837-4053","authenticated-orcid":false,"given":"Srini V","family":"Kaveri","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 06, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"INSERM, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"Laboratoire International Associ\u00e9 INSERM , F-75013 Paris ,","place":["France"]},{"name":"Indian Council of Medical Research , New Delhi 110029 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Legendre","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie-Transplantation, H\u00f4pital Necker, Assistance Publique-H\u00f4pitaux de Paris , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Lacroix-Desmazes","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 06, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"INSERM, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Unit\u00e9 Mixte de Recherche S1138, Centre de Recherche des Cordeliers , F-75006 Paris ,","place":["France"]},{"name":"Laboratoire International Associ\u00e9 INSERM , F-75013 Paris ,","place":["France"]},{"name":"Indian Council of Medical Research , New Delhi 110029 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,5,15]]},"reference":[{"key":"2025030702164188600_r1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.autrev.2012.10.009","article-title":"Antibody-mediated catalysis: induction and therapeutic relevance","volume":"12","author":"Mahendra","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"2025030702164188600_r2","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.2727702","article-title":"Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody","volume":"244","author":"Paul","year":"1989","journal-title":"Science"},{"key":"2025030702164188600_r3","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.4049\/jimmunol.154.7.3328","article-title":"Catalytic activity of anti-thyroglobulin antibodies","volume":"154","author":"Li","year":"1995","journal-title":"J. Immunol."},{"key":"2025030702164188600_r4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1073\/pnas.0509849103","article-title":"Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen","volume":"103","author":"Ponomarenko","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702164188600_r5","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1585181","article-title":"DNA hydrolyzing autoantibodies","volume":"256","author":"Shuster","year":"1992","journal-title":"Science"},{"key":"2025030702164188600_r6","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1056\/NEJMoa011979","article-title":"The prevalence of proteolytic antibodies against factor VIII in hemophilia A","volume":"346","author":"Lacroix-Desmazes","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"2025030702164188600_r7","first-page":"935","article-title":"Human breast milk immunoglobulins G hydrolyze nucleotides","volume":"63","author":"Semenov","year":"1998","journal-title":"Biochemistry (Mosc.)"},{"key":"2025030702164188600_r8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12033-007-0003-7","article-title":"Naturally occurring catalytic antibodies: evidence for preferred development of the catalytic function in IgA class antibodies","volume":"36","author":"Mitsuda","year":"2007","journal-title":"Mol. Biotechnol."},{"key":"2025030702164188600_r9","doi-asserted-by":"crossref","first-page":"14024","DOI":"10.1074\/jbc.M312152200","article-title":"Ontogeny of proteolytic immunity: IgM serine proteases","volume":"279","author":"Planque","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2025030702164188600_r10","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1073\/pnas.0500586102","article-title":"High levels of catalytic antibodies correlate with favorable outcome in sepsis","volume":"102","author":"Lacroix-Desmazes","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702164188600_r11","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1182\/blood-2010-07-296103","article-title":"Proteolytic antibodies activate factor IX in patients with acquired hemophilia","volume":"117","author":"Wootla","year":"2011","journal-title":"Blood"},{"key":"2025030702164188600_r12","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.4049\/jimmunol.180.12.8455","article-title":"Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients","volume":"180","author":"Wootla","year":"2008","journal-title":"J. Immunol."},{"key":"2025030702164188600_r13","doi-asserted-by":"crossref","first-page":"15257","DOI":"10.1074\/jbc.270.25.15257","article-title":"Natural catalytic antibodies: peptide-hydrolyzing activities of Bence Jones proteins and VL fragment","volume":"270","author":"Paul","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2025030702164188600_r14","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1128\/iai.65.10.3997-4004.1997","article-title":"Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans","volume":"65","author":"Quan","year":"1997","journal-title":"Infect. Immun."},{"key":"2025030702164188600_r15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0167-5699(97)01234-6","article-title":"Superantibody activities: new players in innate and adaptive immune responses","volume":"19","author":"Kohler","year":"1998","journal-title":"Immunol. Today"},{"key":"2025030702164188600_r16","doi-asserted-by":"crossref","first-page":"e70731","DOI":"10.1371\/journal.pone.0070731","article-title":"IVIg treatment reduces catalytic antibody titers of renal transplanted patients","volume":"8","author":"Mahendra","year":"2013","journal-title":"PLoS One"},{"key":"2025030702164188600_r17","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.4049\/jimmunol.155.5.2695","article-title":"Unexpected presence of polyreactive catalytic antibodies in IgG from unimmunized donors and decreased levels in rheumatoid arthritis","volume":"155","author":"Kalaga","year":"1995","journal-title":"J. Immunol."},{"key":"2025030702164188600_r18","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/01.TP.0000079630.68668.C2","article-title":"Tissue factor antisense oligonucleotides prevent renal ischemia-reperfusion injury","volume":"76","author":"Matsuyama","year":"2003","journal-title":"Transplantation"},{"key":"2025030702164188600_r19","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.febslet.2009.07.009","article-title":"Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia","volume":"583","author":"Wootla","year":"2009","journal-title":"FEBS Lett."},{"key":"2025030702164188600_r20","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.4049\/jimmunol.177.2.1355","article-title":"Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII","volume":"177","author":"Lacroix-Desmazes","year":"2006","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/10\/4075\/62252918\/1403005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/10\/4075\/62252918\/1403005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T02:37:35Z","timestamp":1741315055000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/196\/10\/4075\/7961482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,5,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1403005","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2016,5]]},"published":{"date-parts":[[2016,5]]}}}