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In this study, we use a model of chronic obstructive pulmonary disease airway disease utilizing adenoviral delivery of IL-1\u03b2 to determine that adaptive T cell immunity is required for airway remodeling because mice deficient in \u03b1\/\u03b2 T cells (tcra\u2212\/\u2212) are protected. Dendritic cells (DCs) accumulate around chronic obstructive pulmonary disease airways and are critical to prime adaptive immunity, but they have not been shown to directly influence airway remodeling. We show that DC depletion or deficiency in the crucial DC chemokine receptor ccr6 both protect from adenoviral IL-1\u03b2\u2013induced airway adaptive T cell immune responses and fibrosis in mice. These results provide evidence that chronic airway inflammation, mediated by accumulation of \u03b1\/\u03b2 T cells and driven by DCs, is critical to airway fibrosis.<\/jats:p>","DOI":"10.4049\/jimmunol.1403043","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T02:34:11Z","timestamp":1426732451000},"page":"3962-3969","source":"Crossref","is-referenced-by-count":13,"title":["A Critical Role for Dendritic Cells in the Evolution of IL-1\u03b2\u2013Mediated Murine Airway Disease"],"prefix":"10.1093","volume":"194","author":[{"given":"Mitsuo","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Pathology, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Minagawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Goodsell","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Royce","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Moermans","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate J","family":"McKnelly","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody L","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F","family":"Krummel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California , San Francisco, San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,15]]},"reference":[{"key":"2025030706052087000_r1","first-page":"1","article-title":"Deaths: preliminary data for 2008","volume":"59","author":"Mini\u00f1o","year":"2010","journal-title":"Natl. 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